Blood donor, product, and transfusion recipient characteristics
| Characteristic . | No. of transfusion episodes (N = 6220 events) . |
|---|---|
| Donor demographic characteristics | |
| Sex, male, n (%) | 3554 (57.1) |
| Age, mean (SD), y | 53 (15) |
| Rh-positive status, n (%) | 5056 (81.3) |
| Blood type, n (%) | |
| A | 2290 (36.8) |
| AB | 190 (3.0) |
| B | 887 (14.3) |
| O | 2853 (45.9) |
| Fingerstick hemoglobin level, mean (SD), g/dL | 14.4 (1.2) |
| Donor genetic characteristics∗ | |
| PFKP (hypoxanthine: RS2388595) | 973 (14.5) |
| SL7A5 (kynurenine: RS8052118) | 526 (8.8) |
| P53 (HETE: RS80649467) | 434 (7.3) |
| ABCG2 (urate: RS138409370) | 119 (2.0) |
| Blood product characteristics | |
| Apheresis-derived, n (%) | 387 (6.2) |
| Irradiated, n (%) | 1651 (26.5) |
| RBC storage duration, median (IQR), d | 27 (15-36) |
| Storage solution, n (%) | |
| AS-1 | 3049 (49.2) |
| AS-3 | 2701 (43.6) |
| Other | 470 (7.6) |
| Transfusion recipient characteristics | N = 5386 recipients |
| Sex, male, n (%) | 3332 (53.6) |
| Age, mean (SD), y | 63 (16) |
| Body mass index, median (IQR), kg/m2 | 28 (24-33) |
| Rh-positive status, n (%) | 4776 (88.8) |
| Blood type, n (%) | |
| A | 2089 (38.8) |
| AB | 300 (5.6) |
| B | 814 (15.1) |
| O | 2183 (40.5) |
| Pretransfusion hemoglobin level, mean (SD), g/dL | 7.4 (0.9) |
| Characteristic . | No. of transfusion episodes (N = 6220 events) . |
|---|---|
| Donor demographic characteristics | |
| Sex, male, n (%) | 3554 (57.1) |
| Age, mean (SD), y | 53 (15) |
| Rh-positive status, n (%) | 5056 (81.3) |
| Blood type, n (%) | |
| A | 2290 (36.8) |
| AB | 190 (3.0) |
| B | 887 (14.3) |
| O | 2853 (45.9) |
| Fingerstick hemoglobin level, mean (SD), g/dL | 14.4 (1.2) |
| Donor genetic characteristics∗ | |
| PFKP (hypoxanthine: RS2388595) | 973 (14.5) |
| SL7A5 (kynurenine: RS8052118) | 526 (8.8) |
| P53 (HETE: RS80649467) | 434 (7.3) |
| ABCG2 (urate: RS138409370) | 119 (2.0) |
| Blood product characteristics | |
| Apheresis-derived, n (%) | 387 (6.2) |
| Irradiated, n (%) | 1651 (26.5) |
| RBC storage duration, median (IQR), d | 27 (15-36) |
| Storage solution, n (%) | |
| AS-1 | 3049 (49.2) |
| AS-3 | 2701 (43.6) |
| Other | 470 (7.6) |
| Transfusion recipient characteristics | N = 5386 recipients |
| Sex, male, n (%) | 3332 (53.6) |
| Age, mean (SD), y | 63 (16) |
| Body mass index, median (IQR), kg/m2 | 28 (24-33) |
| Rh-positive status, n (%) | 4776 (88.8) |
| Blood type, n (%) | |
| A | 2089 (38.8) |
| AB | 300 (5.6) |
| B | 814 (15.1) |
| O | 2183 (40.5) |
| Pretransfusion hemoglobin level, mean (SD), g/dL | 7.4 (0.9) |
IQR, interquartile range. AS-1, additive solution 1; AS-3, additive solution 3.
Prevalence of homozygous recessive alleles in n (%).