Coagulation studies by study visit
| . | Hemoglobin g/dL (SD) . | Hematocrit (%) . | Platelet count, ×103/μL (SD) . | VWF:Ag IU/mL (SD) . | VWF:RCo IU/mL (SD) . | FVIII IU/mL (SD) . | Fibrinogen mg/dL (SD) . | D-dimer μg/mL (SD) . |
|---|---|---|---|---|---|---|---|---|
| Third trimester∗ | ||||||||
| rVWF + TXA | 12.1 (0.9) | 35.7 (2.9) | 217 (68.9) | 1.89 (1.1) | 1.0 (0.5) | 1.6 (0.5) | 521 (109.3) | 1.3 (0.9) |
| rVWF | 11.8 (1.0) | 34.9 (2.6) | 268 (61.7) | 1.41 (0.6) | 1.08 (0.7) | 1.5 (0.5) | 525.2 (122.3) | 0.9 (0.3) |
| Admission for delivery | ||||||||
| rVWF + TXA | 12.6 (1.2) | 37.0 (3.6) | 202 (61.5) | 2.2 (1.1) | 0.97 (0.5) | 1.6 (0.6) | 512.4 (150.4) | 1.3 (0.8) |
| rVWF† | 11.9 (1.0) | 35.3 (3.0) | 253 (83.2) | 2.0 (1.0) | 1.1 (0.6) | 1.8 (0.6) | 500.3 (108.8) | 1.2 (0.5) |
| 24 h postpartum | ||||||||
| rVWF + TXA‡ | 11.7 (1.8) | 34.5 (4.8) | 207 (62.6) | 3.3 (0.9) | 1.9 (0.9) | 1.8 (0.5) | 489.5 (116.2) | 1.7 (1.1) |
| rVWF | 10.8 (1.8) | 32.6 (5.7) | 210 (70.5) | 3.4 (1.3) | 2.2 (0.9) | 1.8 (0.5) | 499.6 (116.8) | 4.7 (5.1) |
| 48 h postpartum | ||||||||
| rVWF + TXA§ | 11.0 (1.9) | 33.0 (4.8) | 239 (238.9) | 4.0 (1.2) | 2.3 (0.6) | 2.1 (0.4) | 562 (96.8) | 1.1 (0.5) |
| rVWF|| | 10.5 (1.9) | 31.5 (5.7) | 207 (68.0) | 3.5 (0.9) | 2.1 (0.8) | 2.0 (0.4) | 497 (149.2) | 1.6 (1.1) |
| 21 d postpartum | ||||||||
| rVWF +TXA¶ | 13.5 (1.8) | 40.7 (4.7) | 290 (88.4) | 0.9 (0.7) | 0.5 (0.2) | 2.1 (0.4) | 320.4 (107.1) | 0.6 (0.4) |
| rVWF | 12.9 (1.0) | 39.1 (3.2) | 361 (99.5) | 0.9 (0.3) | 0.5 (0.2) | 2.0 (0.4) | 293.7 (50.4) | 0.6 (0.5) |
| . | Hemoglobin g/dL (SD) . | Hematocrit (%) . | Platelet count, ×103/μL (SD) . | VWF:Ag IU/mL (SD) . | VWF:RCo IU/mL (SD) . | FVIII IU/mL (SD) . | Fibrinogen mg/dL (SD) . | D-dimer μg/mL (SD) . |
|---|---|---|---|---|---|---|---|---|
| Third trimester∗ | ||||||||
| rVWF + TXA | 12.1 (0.9) | 35.7 (2.9) | 217 (68.9) | 1.89 (1.1) | 1.0 (0.5) | 1.6 (0.5) | 521 (109.3) | 1.3 (0.9) |
| rVWF | 11.8 (1.0) | 34.9 (2.6) | 268 (61.7) | 1.41 (0.6) | 1.08 (0.7) | 1.5 (0.5) | 525.2 (122.3) | 0.9 (0.3) |
| Admission for delivery | ||||||||
| rVWF + TXA | 12.6 (1.2) | 37.0 (3.6) | 202 (61.5) | 2.2 (1.1) | 0.97 (0.5) | 1.6 (0.6) | 512.4 (150.4) | 1.3 (0.8) |
| rVWF† | 11.9 (1.0) | 35.3 (3.0) | 253 (83.2) | 2.0 (1.0) | 1.1 (0.6) | 1.8 (0.6) | 500.3 (108.8) | 1.2 (0.5) |
| 24 h postpartum | ||||||||
| rVWF + TXA‡ | 11.7 (1.8) | 34.5 (4.8) | 207 (62.6) | 3.3 (0.9) | 1.9 (0.9) | 1.8 (0.5) | 489.5 (116.2) | 1.7 (1.1) |
| rVWF | 10.8 (1.8) | 32.6 (5.7) | 210 (70.5) | 3.4 (1.3) | 2.2 (0.9) | 1.8 (0.5) | 499.6 (116.8) | 4.7 (5.1) |
| 48 h postpartum | ||||||||
| rVWF + TXA§ | 11.0 (1.9) | 33.0 (4.8) | 239 (238.9) | 4.0 (1.2) | 2.3 (0.6) | 2.1 (0.4) | 562 (96.8) | 1.1 (0.5) |
| rVWF|| | 10.5 (1.9) | 31.5 (5.7) | 207 (68.0) | 3.5 (0.9) | 2.1 (0.8) | 2.0 (0.4) | 497 (149.2) | 1.6 (1.1) |
| 21 d postpartum | ||||||||
| rVWF +TXA¶ | 13.5 (1.8) | 40.7 (4.7) | 290 (88.4) | 0.9 (0.7) | 0.5 (0.2) | 2.1 (0.4) | 320.4 (107.1) | 0.6 (0.4) |
| rVWF | 12.9 (1.0) | 39.1 (3.2) | 361 (99.5) | 0.9 (0.3) | 0.5 (0.2) | 2.0 (0.4) | 293.7 (50.4) | 0.6 (0.5) |
Hemoglobin, platelet, and coagulation studies over study visits.
SD, standard deviation.
Third trimester laboratory data were collected between 32 and 36 weeks gestation.
An annotation for missing laboratory values is 1 missed blood draw.
An annotation for missing laboratory values are 2 missing platelet counts and 1 missing hemoglobin.
An annotation for missing laboratory values is 1 patients missing all values.
An annotation for missing laboratory values is 1 patient missing hemoglobin and platelet values.
An annotation for missing laboratory values is 1 patient did not have VWF:Ag, VWF:RCo, FVIII, fibrinogen, or D-dimer collected mean and standard deviation of the mean calculated for available laboratory data.