Any-grade infection events in 4 or more patients and grade 3/4 infections in any cohort
| . | 0.4 mg/kg weekly (n = 143) . | 0.8 mg/kg EOW (n = 145) . | Prior TCR (n = 51) . |
|---|---|---|---|
| Infections | |||
| COVID-19 | 15 (10.5) | 34 (23.4) | 6 (11.8) |
| Upper respiratory tract infection | 18 (12.6) | 13 (9.0) | 9 (17.6) |
| Nasopharyngitis | 14 (9.8) | 10 (6.9) | 2 (3.9) |
| Urinary tract infection | 14 (9.8) | 6 (4.1) | 6 (11.8) |
| Pneumonia | 11 (7.7) | 9 (6.2) | 3 (5.9) |
| Bronchitis | 12 (8.4) | 6 (4.1) | 0 |
| Rhinovirus infection | 4 (2.8) | 6 (4.1) | 4 (7.8) |
| Respiratory tract infection | 6 (4.2) | 4 (2.8) | 3 (5.9) |
| Oral candidiasis | 5 (3.5) | 4 (2.8) | 2 (3.9) |
| Gastroenteritis | 5 (3.5) | 1 (0.7) | 2 (3.9) |
| Pharyngitis | 2 (1.4) | 4 (2.8) | 2 (3.9) |
| Sinusitis | 3 (2.1) | 4 (2.8) | 1 (2.0) |
| Rhinitis | 4 (2.8) | 1 (0.7) | 0 |
| Grade 3/4 infections | |||
| Pneumonia | 5 (3.5) | 3 (2.1) | 3 (5.9) |
| COVID-19 | 2 (1.4) | 3 (2.1) | 1 (2.0) |
| Urinary tract infection | 3 (2.1) | 0 | 2 (3.9) |
| COVID-19 pneumonia | 1 (0.7) | 2 (1.4) | 1 (2.0) |
| Sepsis | 2 (1.4) | 1 (0.7) | 0 |
| Cellulitis | 0 | 2 (1.4) | 0 |
| Infection (unknown etiology) | 0 | 2 (1.4) | 0 |
| Bronchiolitis | 1 (0.7) | 1 (0.7) | 0 |
| Device-related infection | 1 (0.7) | 1 (0.7) | 0 |
| Escherichia urinary tract infection | 1 (0.7) | 0 | 1 (2.0) |
| Respiratory syncytial virus | 1 (0.7) | 1 (0.7) | 0 |
| Septic shock | 1 (0.7) | 1 (0.7) | 0 |
| Sinusitis | 0 | 1 (0.7) | 1 (2.0) |
| Staphylococcus infection | 1 (0.7) | 1 (0.7) | 0 |
| Upper respiratory tract infection | 1 (0.7) | 1 (0.7) | 0 |
| Bacteremia | 1 (0.7) | 0 | 0 |
| Bacterial prostatitis | 1 (0.7) | 0 | 0 |
| Disseminated varicella zoster virus infection | 0 | 0 | 1 (2.0) |
| Diverticulitis | 0 | 1 (0.7) | 0 |
| Enterobacter bacteremia | 1 (0.7) | 0 | 0 |
| Escherichia sepsis | 0 | 0 | 1 (2.0) |
| Fungal sepsis | 1 (0.7) | 0 | 0 |
| Gastroenteritis, Escherichia coli | 1 (0.7) | 0 | 0 |
| Herpes zoster | 1 (0.7) | 0 | 0 |
| Human ehrlichiosis | 1 (0.7) | 0 | 0 |
| Implant site infection | 1 (0.7) | 0 | 0 |
| Influenza | 1 (0.7) | 0 | 0 |
| Klebsiella bacteremia | 1 (0.7) | 0 | 0 |
| Klebsiella sepsis | 0 | 1 (0.7) | 0 |
| Large intestine infection | 0 | 1 (0.7) | 0 |
| Metapneumovirus infection | 0 | 0 | 1 (2.0) |
| Esophageal candidiasis | 1 (0.7) | 0 | 0 |
| Parainfluenzae virus infection | 1 (0.7) | 0 | 0 |
| Pneumococcus sepsis | 0 | 0 | 1 (2.0) |
| Pneumonia influenza | 0 | 0 | 1 (2.0) |
| Pseudomonas bacteremia | 0 | 1 (0.7) | 0 |
| Rash pustular | 0 | 0 | 1 (2.0) |
| Respiratory tract infection | 0 | 1 (0.7) | 0 |
| Retinitis | 1 (0.7) | 0 | 0 |
| Rhinovirus infection | 1 (0.7) | 0 | 0 |
| Salmonella sepsis | 0 | 1 (0.7) | 0 |
| Skin infection | 0 | 1 (0.7) | 0 |
| Staphylococcus bacteremia | 0 | 1 (0.7) | 0 |
| Staphylococcus sepsis | 1 (0.7) | 0 | 0 |
| Streptococcus bacteremia | 1 (0.7) | 0 | 0 |
| Streptococcus pneumonia | 0 | 1 (0.7) | 0 |
| Urinary tract infection, Pseudomonas | 0 | 0 | 1 (2.0) |
| Vascular device infection | 0 | 0 | 1 (2.0) |
| . | 0.4 mg/kg weekly (n = 143) . | 0.8 mg/kg EOW (n = 145) . | Prior TCR (n = 51) . |
|---|---|---|---|
| Infections | |||
| COVID-19 | 15 (10.5) | 34 (23.4) | 6 (11.8) |
| Upper respiratory tract infection | 18 (12.6) | 13 (9.0) | 9 (17.6) |
| Nasopharyngitis | 14 (9.8) | 10 (6.9) | 2 (3.9) |
| Urinary tract infection | 14 (9.8) | 6 (4.1) | 6 (11.8) |
| Pneumonia | 11 (7.7) | 9 (6.2) | 3 (5.9) |
| Bronchitis | 12 (8.4) | 6 (4.1) | 0 |
| Rhinovirus infection | 4 (2.8) | 6 (4.1) | 4 (7.8) |
| Respiratory tract infection | 6 (4.2) | 4 (2.8) | 3 (5.9) |
| Oral candidiasis | 5 (3.5) | 4 (2.8) | 2 (3.9) |
| Gastroenteritis | 5 (3.5) | 1 (0.7) | 2 (3.9) |
| Pharyngitis | 2 (1.4) | 4 (2.8) | 2 (3.9) |
| Sinusitis | 3 (2.1) | 4 (2.8) | 1 (2.0) |
| Rhinitis | 4 (2.8) | 1 (0.7) | 0 |
| Grade 3/4 infections | |||
| Pneumonia | 5 (3.5) | 3 (2.1) | 3 (5.9) |
| COVID-19 | 2 (1.4) | 3 (2.1) | 1 (2.0) |
| Urinary tract infection | 3 (2.1) | 0 | 2 (3.9) |
| COVID-19 pneumonia | 1 (0.7) | 2 (1.4) | 1 (2.0) |
| Sepsis | 2 (1.4) | 1 (0.7) | 0 |
| Cellulitis | 0 | 2 (1.4) | 0 |
| Infection (unknown etiology) | 0 | 2 (1.4) | 0 |
| Bronchiolitis | 1 (0.7) | 1 (0.7) | 0 |
| Device-related infection | 1 (0.7) | 1 (0.7) | 0 |
| Escherichia urinary tract infection | 1 (0.7) | 0 | 1 (2.0) |
| Respiratory syncytial virus | 1 (0.7) | 1 (0.7) | 0 |
| Septic shock | 1 (0.7) | 1 (0.7) | 0 |
| Sinusitis | 0 | 1 (0.7) | 1 (2.0) |
| Staphylococcus infection | 1 (0.7) | 1 (0.7) | 0 |
| Upper respiratory tract infection | 1 (0.7) | 1 (0.7) | 0 |
| Bacteremia | 1 (0.7) | 0 | 0 |
| Bacterial prostatitis | 1 (0.7) | 0 | 0 |
| Disseminated varicella zoster virus infection | 0 | 0 | 1 (2.0) |
| Diverticulitis | 0 | 1 (0.7) | 0 |
| Enterobacter bacteremia | 1 (0.7) | 0 | 0 |
| Escherichia sepsis | 0 | 0 | 1 (2.0) |
| Fungal sepsis | 1 (0.7) | 0 | 0 |
| Gastroenteritis, Escherichia coli | 1 (0.7) | 0 | 0 |
| Herpes zoster | 1 (0.7) | 0 | 0 |
| Human ehrlichiosis | 1 (0.7) | 0 | 0 |
| Implant site infection | 1 (0.7) | 0 | 0 |
| Influenza | 1 (0.7) | 0 | 0 |
| Klebsiella bacteremia | 1 (0.7) | 0 | 0 |
| Klebsiella sepsis | 0 | 1 (0.7) | 0 |
| Large intestine infection | 0 | 1 (0.7) | 0 |
| Metapneumovirus infection | 0 | 0 | 1 (2.0) |
| Esophageal candidiasis | 1 (0.7) | 0 | 0 |
| Parainfluenzae virus infection | 1 (0.7) | 0 | 0 |
| Pneumococcus sepsis | 0 | 0 | 1 (2.0) |
| Pneumonia influenza | 0 | 0 | 1 (2.0) |
| Pseudomonas bacteremia | 0 | 1 (0.7) | 0 |
| Rash pustular | 0 | 0 | 1 (2.0) |
| Respiratory tract infection | 0 | 1 (0.7) | 0 |
| Retinitis | 1 (0.7) | 0 | 0 |
| Rhinovirus infection | 1 (0.7) | 0 | 0 |
| Salmonella sepsis | 0 | 1 (0.7) | 0 |
| Skin infection | 0 | 1 (0.7) | 0 |
| Staphylococcus bacteremia | 0 | 1 (0.7) | 0 |
| Staphylococcus sepsis | 1 (0.7) | 0 | 0 |
| Streptococcus bacteremia | 1 (0.7) | 0 | 0 |
| Streptococcus pneumonia | 0 | 1 (0.7) | 0 |
| Urinary tract infection, Pseudomonas | 0 | 0 | 1 (2.0) |
| Vascular device infection | 0 | 0 | 1 (2.0) |
Percentages are calculated with the number of patients in the all-treated analysis set in each cohort as the denominator.