Summary of infection and cytopenia events
| . | 0.4 mg/kg weekly (n = 143) . | 0.8 mg/kg EOW (n = 145) . | Prior TCR (n = 51) . |
|---|---|---|---|
| Infections, n (%) | |||
| Any grade | 84 (58.7) | 96 (66.2) | 37 (72.5) |
| Grade 3/4 | 31 (21.7) | 23 (15.9) | 14 (27.5) |
| Led to death | 3 (2.1) | 2 (1.4) | 0 |
| Led to discontinuation | 2 (1.4) | 0 | 1 (2.0) |
| Led to dose interruption | 45 (31.5) | 49 (33.8) | 19 (37.3) |
| Neutropenia, n (%) | |||
| Any grade | 50 (35.0) | 41 (28.3) | 28 (54.9) |
| Grade 3/4 neutropenia | 44 (30.8) | 32 (22.1) | 27 (52.9) |
| Any infection + concomitant grade 3/4 neutropenia | 11 (7.7) | 3 (2.1) | 9 (17.6) |
| Grade 3/4 infection + concomitant grade 3/4 neutropenia | 4 (2.8) | 1 (0.7) | 1 (2.0) |
| Anemia, n (%) | |||
| Any grade | 64 (44.8) | 66 (45.5) | 25 (49.0) |
| Grade 3/4 | 45 (31.5)∗ | 40 (27.6)∗ | 14 (27.5)∗ |
| Lymphopenia, n (%) | |||
| Any grade | 40 (28.0) | 42 (29.0) | 9 (17.6) |
| Grade 3/4 | 37 (25.9) | 39 (26.9) | 7 (13.7) |
| Thrombocytopenia, n (%) | |||
| Any grade | 39 (27.3) | 43 (29.7) | 19 (37.3) |
| Grade 3/4 | 29 (20.3) | 27 (18.6) | 15 (29.4) |
| Leukopenia, n (%) | |||
| Any grade | 23 (16.1) | 27 (18.6) | 12 (23.5) |
| Grade 3/4 | 11 (7.7) | 18 (12.4) | 9 (17.6) |
| . | 0.4 mg/kg weekly (n = 143) . | 0.8 mg/kg EOW (n = 145) . | Prior TCR (n = 51) . |
|---|---|---|---|
| Infections, n (%) | |||
| Any grade | 84 (58.7) | 96 (66.2) | 37 (72.5) |
| Grade 3/4 | 31 (21.7) | 23 (15.9) | 14 (27.5) |
| Led to death | 3 (2.1) | 2 (1.4) | 0 |
| Led to discontinuation | 2 (1.4) | 0 | 1 (2.0) |
| Led to dose interruption | 45 (31.5) | 49 (33.8) | 19 (37.3) |
| Neutropenia, n (%) | |||
| Any grade | 50 (35.0) | 41 (28.3) | 28 (54.9) |
| Grade 3/4 neutropenia | 44 (30.8) | 32 (22.1) | 27 (52.9) |
| Any infection + concomitant grade 3/4 neutropenia | 11 (7.7) | 3 (2.1) | 9 (17.6) |
| Grade 3/4 infection + concomitant grade 3/4 neutropenia | 4 (2.8) | 1 (0.7) | 1 (2.0) |
| Anemia, n (%) | |||
| Any grade | 64 (44.8) | 66 (45.5) | 25 (49.0) |
| Grade 3/4 | 45 (31.5)∗ | 40 (27.6)∗ | 14 (27.5)∗ |
| Lymphopenia, n (%) | |||
| Any grade | 40 (28.0) | 42 (29.0) | 9 (17.6) |
| Grade 3/4 | 37 (25.9) | 39 (26.9) | 7 (13.7) |
| Thrombocytopenia, n (%) | |||
| Any grade | 39 (27.3) | 43 (29.7) | 19 (37.3) |
| Grade 3/4 | 29 (20.3) | 27 (18.6) | 15 (29.4) |
| Leukopenia, n (%) | |||
| Any grade | 23 (16.1) | 27 (18.6) | 12 (23.5) |
| Grade 3/4 | 11 (7.7) | 18 (12.4) | 9 (17.6) |
Percentages are calculated with the number of patients in the all-treated analysis set in each cohort as the denominator.
Grade 3 only.