Table 2. Summary of key clinical... | American Society of Hematology

Table 2.

Summary of key clinical features of non-DLBCL monomorphic PTLD and HL-type PTLD as reported in the largest retrospective studies to date

PTLD subtype	Early- vs late-onset PTLD	Most common transplanted organ	EBV association (%)	Site predilection	Genetic features remark
BL	Late	Kidney	49% to 69%	Gastrointestinal tract is the most common site CNS involvement in 7% to 13% of cases	MYC translocations
T/NK-cell PTLD	Late	Kidney, heart	33%	Bone marrow, peripheral blood, and spleen are the most common sites	Molecular features resemble those in immunocompetent individuals with T/NK-cell lymphomas
Plasmacytoma-like PTLD	Late	No clear organ preference	Up to 50%	Similar to non-PTLD setting, although osseous involvement is less frequent Graft involvement is rare	NA
PCM-PTLD	Late	Kidney	Rare	Similar to non-PTLD setting, although osseous involvement is less frequent	FISH/cytogenetic findings similar to non-PTLD myeloma
Plasmablastic lymphoma	Late to very late	Heart, kidney	55% to 63%	Primarily extranodal	MYC rearrangements reported in 33% to 45% of cases
PCNS-PTLD	Late to very late	Kidney	>90%	Lobar regions, basal ganglia, and thalamus are the most common sites Leptomeningeal and ocular involvement is rare	Unlike PCNS lymphoma, MYD88 alterations are rare, except in some EBV-negative cases
HL-PTLD	Late	Kidney	74%	No predilection but extranodal disease is more common than in immunocompetent patients	NA

PTLD subtype	Early- vs late-onset PTLD	Most common transplanted organ	EBV association (%)	Site predilection	Genetic features remark
BL	Late	Kidney	49% to 69%	Gastrointestinal tract is the most common site CNS involvement in 7% to 13% of cases	MYC translocations
T/NK-cell PTLD	Late	Kidney, heart	33%	Bone marrow, peripheral blood, and spleen are the most common sites	Molecular features resemble those in immunocompetent individuals with T/NK-cell lymphomas
Plasmacytoma-like PTLD	Late	No clear organ preference	Up to 50%	Similar to non-PTLD setting, although osseous involvement is less frequent Graft involvement is rare	NA
PCM-PTLD	Late	Kidney	Rare	Similar to non-PTLD setting, although osseous involvement is less frequent	FISH/cytogenetic findings similar to non-PTLD myeloma
Plasmablastic lymphoma	Late to very late	Heart, kidney	55% to 63%	Primarily extranodal	MYC rearrangements reported in 33% to 45% of cases
PCNS-PTLD	Late to very late	Kidney	>90%	Lobar regions, basal ganglia, and thalamus are the most common sites Leptomeningeal and ocular involvement is rare	Unlike PCNS lymphoma, MYD88 alterations are rare, except in some EBV-negative cases
HL-PTLD	Late	Kidney	74%	No predilection but extranodal disease is more common than in immunocompetent patients	NA

FISH, fluorescence in situ hybridization; NA, not available.