Univariate and multivariate longitudinal associations with ECV
| Variable . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|
| Estimate . | 95% CI . | P value . | Estimate . | 95% CI . | P value . | |
| Demographic/clinical | ||||||
| Age | 0.01 | −0.22 to 0.27 | .83 | |||
| Sex (female reference) | −1.8 | −3.8 to 0.21 | .08 | |||
| Acute care events | 0.24 | −0.01 to 0.47 | .05 | |||
| Systolic BP | −0.41 | −0.6 to −0.19 | .001 | |||
| Diastolic BP | −0.36 | −0.55 to −0.13 | .003 | |||
| Diastolic function | ||||||
| Normal | Ref | |||||
| Inconclusive | 4.7 | 2.7-6.8 | <.001 | 3.89 | 1.75-6 | <.001 |
| Dysfunction | 5.4 | 2.9-8 | <.001 | 4.52 | 1.8-7.26 | .0016 |
| Laboratory | ||||||
| Fetal Hb | −0.24 | −0.46 to 0.01 | .049 | |||
| Hemoglobin | −0.59 | −0.73 to −0.4 | <.001 | −1.48 | −2.29 to −0.69 | .001 |
| Reticulocyte count | 0.37 | 0.13-0.56 | .003 | |||
| Log NT-proBNP | 0.49 | 0.28-0.66 | <.001 | 1.01 | 0.25-1.88 | .022 |
| Direct bilirubin | 0.28 | 0.03-0.5 | .023 | |||
| Absolute eosinophil count | 0.33 | 0.08-0.54 | .008 | |||
| Imaging | ||||||
| LAVi | 0.31 | 0.07-0.51 | .013 | 0.1 | 0.01-0.19 | .037 |
| LVEDVi | 0.37 | 0.13-0.57 | .003 | |||
| RVEDVi∗ | 0.33 | 0.09-0.54 | .009 | |||
| Native T1 | 0.62 | 0.44-0.75 | <.001 | 0.03 | 0.01-0.05 | .002 |
| Peak MPA velocity | 0.29 | 0.06-0.5 | .016 | 0.04 | 0-0.08 | .029 |
| ECM volume index∗ | 0.65 | 0.47-0.78 | <.001 | |||
| Variable . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|
| Estimate . | 95% CI . | P value . | Estimate . | 95% CI . | P value . | |
| Demographic/clinical | ||||||
| Age | 0.01 | −0.22 to 0.27 | .83 | |||
| Sex (female reference) | −1.8 | −3.8 to 0.21 | .08 | |||
| Acute care events | 0.24 | −0.01 to 0.47 | .05 | |||
| Systolic BP | −0.41 | −0.6 to −0.19 | .001 | |||
| Diastolic BP | −0.36 | −0.55 to −0.13 | .003 | |||
| Diastolic function | ||||||
| Normal | Ref | |||||
| Inconclusive | 4.7 | 2.7-6.8 | <.001 | 3.89 | 1.75-6 | <.001 |
| Dysfunction | 5.4 | 2.9-8 | <.001 | 4.52 | 1.8-7.26 | .0016 |
| Laboratory | ||||||
| Fetal Hb | −0.24 | −0.46 to 0.01 | .049 | |||
| Hemoglobin | −0.59 | −0.73 to −0.4 | <.001 | −1.48 | −2.29 to −0.69 | .001 |
| Reticulocyte count | 0.37 | 0.13-0.56 | .003 | |||
| Log NT-proBNP | 0.49 | 0.28-0.66 | <.001 | 1.01 | 0.25-1.88 | .022 |
| Direct bilirubin | 0.28 | 0.03-0.5 | .023 | |||
| Absolute eosinophil count | 0.33 | 0.08-0.54 | .008 | |||
| Imaging | ||||||
| LAVi | 0.31 | 0.07-0.51 | .013 | 0.1 | 0.01-0.19 | .037 |
| LVEDVi | 0.37 | 0.13-0.57 | .003 | |||
| RVEDVi∗ | 0.33 | 0.09-0.54 | .009 | |||
| Native T1 | 0.62 | 0.44-0.75 | <.001 | 0.03 | 0.01-0.05 | .002 |
| Peak MPA velocity | 0.29 | 0.06-0.5 | .016 | 0.04 | 0-0.08 | .029 |
| ECM volume index∗ | 0.65 | 0.47-0.78 | <.001 | |||
R2 values for multivariate mixed-effects models: (1) demographics: conditional (0.57) and marginal (0.23); (2) laboratory: conditional (0.72) and marginal (0.45); (3) imaging: conditional (0.67) and marginal (0.42).
BP, blood pressure; Ref, reference category (normal diastolic function); RVEDVi, right ventricular end-diastolic volume indexed to body surface area; VIF, variance inflation factor.
Variable omitted due to multicollinearity (VIF > 5).