All serious AEs by preferred term in arm A or arm B
| AE . | Arm A CPX-351 plus venetoclax (N = 27) . | Arm B CPX-351 plus midostaurin (N = 23) . |
|---|---|---|
| Patients with any serious AE, n (%) | 12 (44) | 7 (30) |
| Patients with serious hematologic AE, n (%) | ||
| Febrile neutropenia | 5 (19) | 1 (4) |
| AML | 1 (4) | 0 |
| Patients with serious nonhematologic AE, n (%) | ||
| Sepsis | 3 (11) | 0 |
| Congestive cardiac failure | 1 (4) | 0 |
| Ischemic stroke | 1 (4) | 0 |
| Skin infection | 1 (4) | 0 |
| Acute respiratory failure | 0 | 1 (4) |
| Anemia | 0 | 1 (4) |
| Blood bilirubin increased | 0 | 1 (4) |
| Coronavirus infection | 0 | 1 (4) |
| Delirium | 0 | 1 (4) |
| Ejection fraction decreased | 0 | 1 (4) |
| Myocarditis | 0 | 1 (4) |
| Pericarditis | 0 | 1 (4) |
| Small intestinal obstruction | 0 | 1 (4) |
| Thrombosis | 0 | 1 (4) |
| AE . | Arm A CPX-351 plus venetoclax (N = 27) . | Arm B CPX-351 plus midostaurin (N = 23) . |
|---|---|---|
| Patients with any serious AE, n (%) | 12 (44) | 7 (30) |
| Patients with serious hematologic AE, n (%) | ||
| Febrile neutropenia | 5 (19) | 1 (4) |
| AML | 1 (4) | 0 |
| Patients with serious nonhematologic AE, n (%) | ||
| Sepsis | 3 (11) | 0 |
| Congestive cardiac failure | 1 (4) | 0 |
| Ischemic stroke | 1 (4) | 0 |
| Skin infection | 1 (4) | 0 |
| Acute respiratory failure | 0 | 1 (4) |
| Anemia | 0 | 1 (4) |
| Blood bilirubin increased | 0 | 1 (4) |
| Coronavirus infection | 0 | 1 (4) |
| Delirium | 0 | 1 (4) |
| Ejection fraction decreased | 0 | 1 (4) |
| Myocarditis | 0 | 1 (4) |
| Pericarditis | 0 | 1 (4) |
| Small intestinal obstruction | 0 | 1 (4) |
| Thrombosis | 0 | 1 (4) |
All AEs were coded using Medical Dictionary for Regulatory Activities, version 21.1. Multiple entries for an individual patient under each preferred term were only counted once.