Most frequently reported grade 3 or higher AEs (in more than 10% of patients) by preferred term occurring in arm A or arm B
| AE . | Arm A CPX-351 plus venetoclax (N = 27) . | Arm B CPX-351 plus midostaurin (N = 23) . |
|---|---|---|
| Patients with any grade ≥3 AE, n (%) | 25 (93) | 23 (100) |
| Patients with grade ≥3 hematologic AE, n (%) | ||
| Febrile neutropenia | 17 (63) | 16 (70) |
| Thrombocytopenia | 12 (44) | 15 (65) |
| Leukopenia | 11 (41) | 14 (61) |
| Neutropenia | 10 (37) | 9 (39) |
| Anemia | 5 (19) | 8 (35) |
| Lymphopenia | 3 (11) | 0 |
| Patients with grade ≥3 nonhematologic AE, n (%) | ||
| Hypokalemia | 3 (11) | 1 (4) |
| Hypoxia | 3 (11) | 1 (4) |
| Sepsis | 3 (11) | 1 (4) |
| Syncope | 3 (11) | 0 |
| Pneumonia | 2 (7) | 4 (17) |
| AE . | Arm A CPX-351 plus venetoclax (N = 27) . | Arm B CPX-351 plus midostaurin (N = 23) . |
|---|---|---|
| Patients with any grade ≥3 AE, n (%) | 25 (93) | 23 (100) |
| Patients with grade ≥3 hematologic AE, n (%) | ||
| Febrile neutropenia | 17 (63) | 16 (70) |
| Thrombocytopenia | 12 (44) | 15 (65) |
| Leukopenia | 11 (41) | 14 (61) |
| Neutropenia | 10 (37) | 9 (39) |
| Anemia | 5 (19) | 8 (35) |
| Lymphopenia | 3 (11) | 0 |
| Patients with grade ≥3 nonhematologic AE, n (%) | ||
| Hypokalemia | 3 (11) | 1 (4) |
| Hypoxia | 3 (11) | 1 (4) |
| Sepsis | 3 (11) | 1 (4) |
| Syncope | 3 (11) | 0 |
| Pneumonia | 2 (7) | 4 (17) |
All AEs were coded using Medical Dictionary for Regulatory Activities, version 21.1. Severity grade was coded using Common Terminology Criteria for Adverse Events, version 5.0. Multiple entries for an individual patient under each preferred term were only counted once.