Area-level SES in relation to overall survival among children with ALL in the NCDB, diagnosed between 2004 and 2019, by survival cohort
| Variable . | Multivariable models . | |||||
|---|---|---|---|---|---|---|
| Total cohort . | Conditional survival of ≥2 years . | Conditional survival of ≥5 years . | ||||
| aHR (95% CI) . | P value . | aHR (95% CI) . | P value . | aHR (95% CI) . | P value . | |
| Neighborhood income and education quartiles at cancer diagnosis (ref: Q4: highest education + income quartiles) | ||||||
| Lowest education and income quartiles | 1.55 (1.29-1.88) | <.001 | 1.70 (1.28-2.26) | .001 | 1.87 (1.17-3.00) | .032 |
| All other education/income quartiles | 1.24 (1.07-1.44) | 1.37 (1.10-1.70) | 1.37 (0.96-1.97) | |||
| Year of cancer diagnosis, per 1 year increase | 0.96 (0.94-0.97) | <.001 | 0.94 (0.92-0.96) | <.001 | 0.95 (0.91-0.99) | .015 |
| Age at cancer diagnosis, y (ref: 1-4) | ||||||
| 5-9 | 1.51 (1.31-1.73) | <.001 | 1.24 (1.02-1.51) | <.001 | 1.10 (0.77-1.55) | <.001 |
| 10-14 | 3.15 (2.76-3.59) | 2.50 (2.08-3.01) | 2.38 (1.72-3.29) | |||
| 15-17 | 4.61 (4.01-5.29) | 3.46 (2.83-4.24) | 3.71 (2.65-5.21) | |||
| Sex (ref: female), male | N/A | N/A | N/A | N/A | 1.29 (1.002-1.67) | .048 |
| Race/ethnicity (ref: non-Hispanic White) | ||||||
| Non-Hispanic Black | 1.37 (1.17-1.62) | <.001 | 1.37 (1.07-1.75) | .012 | N/A | N/A |
| American Indian/Alaska Native | 1.16 (0.65-2.06) | 1.38 (0.61-3.11) | N/A | |||
| Asian | 0.97 (0.75-1.26) | 0.97 (0.66-1.43) | N/A | |||
| Hispanic | 1.20 (1.06-1.35) | 1.34 (1.13-1.60) | N/A | |||
| Other | 1.49 (1.04-2.12) | 1.35 (0.76-2.41) | N/A | |||
| Primary payer at diagnosis (ref: private insurance) | ||||||
| Medicaid | 1.18 (1.06-1.32) | .0047 | 1.13 (0.96-1.33) | .097 | 0.83 (0.63-1.11) | .53 |
| Other/uninsured | 1.14 (0.93-1.40) | 0.91 (0.65-1.25) | 0.95 (0.55-1.65) | |||
| Unknown | 1.42 (1.09-1.84) | 1.44 (1.00-2.07) | 1.21 (0.64-2.31) | |||
| Charlson-Deyo score (ref: none), ≥1 | 1.45 (1.21-1.73) | <.001 | N/A | N/A | N/A | N/A |
| Time to treatment (ref: within 1 week), ≥1 week | 1.16 (1.00-1.35) | .051 | 1.23 (0.99-1.53) | .056 | N/A | N/A |
| Distance in miles (ref: ≤50) | ||||||
| 51-100 | N/A | N/A | N/A | N/A | N/A | N/A |
| >100 | N/A | N/A | N/A | |||
| Rural-urban continuum codes (ref: metro), non-metro/rural | N/A | N/A | N/A | N/A | N/A | N/A |
| Variable . | Multivariable models . | |||||
|---|---|---|---|---|---|---|
| Total cohort . | Conditional survival of ≥2 years . | Conditional survival of ≥5 years . | ||||
| aHR (95% CI) . | P value . | aHR (95% CI) . | P value . | aHR (95% CI) . | P value . | |
| Neighborhood income and education quartiles at cancer diagnosis (ref: Q4: highest education + income quartiles) | ||||||
| Lowest education and income quartiles | 1.55 (1.29-1.88) | <.001 | 1.70 (1.28-2.26) | .001 | 1.87 (1.17-3.00) | .032 |
| All other education/income quartiles | 1.24 (1.07-1.44) | 1.37 (1.10-1.70) | 1.37 (0.96-1.97) | |||
| Year of cancer diagnosis, per 1 year increase | 0.96 (0.94-0.97) | <.001 | 0.94 (0.92-0.96) | <.001 | 0.95 (0.91-0.99) | .015 |
| Age at cancer diagnosis, y (ref: 1-4) | ||||||
| 5-9 | 1.51 (1.31-1.73) | <.001 | 1.24 (1.02-1.51) | <.001 | 1.10 (0.77-1.55) | <.001 |
| 10-14 | 3.15 (2.76-3.59) | 2.50 (2.08-3.01) | 2.38 (1.72-3.29) | |||
| 15-17 | 4.61 (4.01-5.29) | 3.46 (2.83-4.24) | 3.71 (2.65-5.21) | |||
| Sex (ref: female), male | N/A | N/A | N/A | N/A | 1.29 (1.002-1.67) | .048 |
| Race/ethnicity (ref: non-Hispanic White) | ||||||
| Non-Hispanic Black | 1.37 (1.17-1.62) | <.001 | 1.37 (1.07-1.75) | .012 | N/A | N/A |
| American Indian/Alaska Native | 1.16 (0.65-2.06) | 1.38 (0.61-3.11) | N/A | |||
| Asian | 0.97 (0.75-1.26) | 0.97 (0.66-1.43) | N/A | |||
| Hispanic | 1.20 (1.06-1.35) | 1.34 (1.13-1.60) | N/A | |||
| Other | 1.49 (1.04-2.12) | 1.35 (0.76-2.41) | N/A | |||
| Primary payer at diagnosis (ref: private insurance) | ||||||
| Medicaid | 1.18 (1.06-1.32) | .0047 | 1.13 (0.96-1.33) | .097 | 0.83 (0.63-1.11) | .53 |
| Other/uninsured | 1.14 (0.93-1.40) | 0.91 (0.65-1.25) | 0.95 (0.55-1.65) | |||
| Unknown | 1.42 (1.09-1.84) | 1.44 (1.00-2.07) | 1.21 (0.64-2.31) | |||
| Charlson-Deyo score (ref: none), ≥1 | 1.45 (1.21-1.73) | <.001 | N/A | N/A | N/A | N/A |
| Time to treatment (ref: within 1 week), ≥1 week | 1.16 (1.00-1.35) | .051 | 1.23 (0.99-1.53) | .056 | N/A | N/A |
| Distance in miles (ref: ≤50) | ||||||
| 51-100 | N/A | N/A | N/A | N/A | N/A | N/A |
| >100 | N/A | N/A | N/A | |||
| Rural-urban continuum codes (ref: metro), non-metro/rural | N/A | N/A | N/A | N/A | N/A | N/A |
Full univariable and multivariable results are found in supplemental Tables 1-3. N/A signifies variables that were not retained in multivariable modeling.
Q4, quartile 4; Ref, reference.