Cotreatment with TQ and ruxolitinib, OTX015, or pelabresib (CPI0610) exerted synergistic lethality against PD post-MPN sAML cells
| Combination agent . | TQ . | ||
|---|---|---|---|
| 5 μM . | 10 μM . | 20 μM . | |
| Ruxolitinib | |||
| 250 nM | 5.604 | 1.308 | 6.535 |
| 500 nM | 3.912 | 5.400 | 4.598 |
| 1000 nM | 8.245 | 5.736 | 9.062 |
| OTX015 | |||
| 50 nM | 2.562 | 3.206 | 4.540 |
| 100 nM | 1.603 | 2.629 | 2.806 |
| 250 nM | 4.041 | 3.840 | 3.838 |
| Pelabresib | |||
| 100 nM | 2.245 | 7.082 | 12.276 |
| 250 nM | 5.561 | 7.764 | 20.382 |
| 500 nM | 2.110 | 3.558 | 20.232 |
| Combination agent . | TQ . | ||
|---|---|---|---|
| 5 μM . | 10 μM . | 20 μM . | |
| Ruxolitinib | |||
| 250 nM | 5.604 | 1.308 | 6.535 |
| 500 nM | 3.912 | 5.400 | 4.598 |
| 1000 nM | 8.245 | 5.736 | 9.062 |
| OTX015 | |||
| 50 nM | 2.562 | 3.206 | 4.540 |
| 100 nM | 1.603 | 2.629 | 2.806 |
| 250 nM | 4.041 | 3.840 | 3.838 |
| Pelabresib | |||
| 100 nM | 2.245 | 7.082 | 12.276 |
| 250 nM | 5.561 | 7.764 | 20.382 |
| 500 nM | 2.110 | 3.558 | 20.232 |
Table shows delta synergy scores for the combination agents with TQ at the doses listed in 3 PD post-MPN sAML cells. Delta synergy scores (ZIP method) of TQ concentrations in PD sAML cells (n = 3).