Safety data of all patients of cohorts 1 and 2
| AE . | No. of events . | Grade . | SAE . | Attribution . |
|---|---|---|---|---|
| Cardiac troponin T increased | 1 | 3 | No | Possible |
| Headache | 1 | 3 | Yes | Possible |
| Hyperbilirubinemia | 1 | 3 | No | Possible |
| Leukopenia | 1 | 3 | No | Possible |
| Neutropenia | 3 | 3 | No | Possible |
| Noncardiac chest pain | 1 | 3 | Yes | Possible |
| Thrombocytopenia | 1 | 3 | No | Definite |
| Abdominal pain | 1 | 2 | No | Possible |
| Abdominal pain | 2 | 2 | No | Probable |
| Anemia | 4 | 2 | No | Possible |
| Generalized edema | 1 | 2 | No | Possible |
| Headache | 1 | 2 | No | Possible |
| Hypokalemia | 2 | 2 | No | Possible |
| Leukopenia | 2 | 2 | No | Possible |
| Nausea | 3 | 2 | No | Definite |
| Neutropenia | 2 | 2 | No | Probable |
| Thromboembolic event | 1 | 2 | No | Possible |
| Transaminitis | 1 | 2 | No | Probable |
| Vomiting | 1 | 2 | No | Possible |
| Weight gain | 1 | 2 | No | Possible |
| Diarrhea | 1 | 2 | No | Possible |
| Creatinine increased | 1 | 2 | No | Possible |
| AE . | No. of events . | Grade . | SAE . | Attribution . |
|---|---|---|---|---|
| Cardiac troponin T increased | 1 | 3 | No | Possible |
| Headache | 1 | 3 | Yes | Possible |
| Hyperbilirubinemia | 1 | 3 | No | Possible |
| Leukopenia | 1 | 3 | No | Possible |
| Neutropenia | 3 | 3 | No | Possible |
| Noncardiac chest pain | 1 | 3 | Yes | Possible |
| Thrombocytopenia | 1 | 3 | No | Definite |
| Abdominal pain | 1 | 2 | No | Possible |
| Abdominal pain | 2 | 2 | No | Probable |
| Anemia | 4 | 2 | No | Possible |
| Generalized edema | 1 | 2 | No | Possible |
| Headache | 1 | 2 | No | Possible |
| Hypokalemia | 2 | 2 | No | Possible |
| Leukopenia | 2 | 2 | No | Possible |
| Nausea | 3 | 2 | No | Definite |
| Neutropenia | 2 | 2 | No | Probable |
| Thromboembolic event | 1 | 2 | No | Possible |
| Transaminitis | 1 | 2 | No | Probable |
| Vomiting | 1 | 2 | No | Possible |
| Weight gain | 1 | 2 | No | Possible |
| Diarrhea | 1 | 2 | No | Possible |
| Creatinine increased | 1 | 2 | No | Possible |
AE, adverse event; SAE, serious AE.