Table 6. GRADE summary of findings for... | American Society of Hematology

Table 6.

GRADE summary of findings for thrombolysis followed by AC vs AC alone in patients with CSVT

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality; follow-up: mean, 3.5 years)
1²⁹	Nonrandomized studies	0/6 (0.0)	0/4 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical
Thrombus resolution (complete; follow-up: mean, 3.5 years; assessed with: imaging)
1²⁹	Nonrandomized studies	6/6 (100.0)	3/4 (75.0)	RR, 1.33 (0.72-2.44)	248 more per 1000 (210 fewer to 1000 more)	⊕○○○ Very low∗,†	Critical
Thrombus resolution (follow-up: mean, 3.5 years; assessed with: complete or partial resolution)
1²⁹	Nonrandomized studies	6/6 (100.0)	4/4 (100.0)	RR, 1.00 (0.70-1.43)	0 fewer per 1000 (300 fewer to 430 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence (follow-up: mean, 3.5 years)
1²⁹	Nonrandomized studies	0/6 (0.0)	0/4 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality; follow-up: mean, 3.5 years)
1²⁹	Nonrandomized studies	0/6 (0.0)	0/4 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical
Thrombus resolution (complete; follow-up: mean, 3.5 years; assessed with: imaging)
1²⁹	Nonrandomized studies	6/6 (100.0)	3/4 (75.0)	RR, 1.33 (0.72-2.44)	248 more per 1000 (210 fewer to 1000 more)	⊕○○○ Very low∗,†	Critical
Thrombus resolution (follow-up: mean, 3.5 years; assessed with: complete or partial resolution)
1²⁹	Nonrandomized studies	6/6 (100.0)	4/4 (100.0)	RR, 1.00 (0.70-1.43)	0 fewer per 1000 (300 fewer to 430 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence (follow-up: mean, 3.5 years)
1²⁹	Nonrandomized studies	0/6 (0.0)	0/4 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical

Risk of bias was assessed using ROBINS-I, we have concerns because of selection bias and confounding.

We downgraded twice for imprecision because of the small sample size and small number of events.