Table 5. GRADE summary of evidence for... | American Society of Hematology

Table 5.

GRADE summary of evidence for thrombolysis followed by AC vs AC alone in patients with RAT

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality)
2²⁷^,²⁸	Nonrandomized studies	2/11 (18.2)	1/13 (7.7)	RD, 0.02 (−0.30 to 0.34)	20 more per 1000 (300 fewer to 340 more)	⊕○○○ Very low∗,†	Critical
Thrombus resolution (assessed with: complete or partial resolution)
3²²^,²⁷^,²⁸	Nonrandomized studies	15/17 (88.2)	25/27 (92.6)	RR, 1.01 (0.84-1.22)	9 more per 1000 (148 fewer to 204 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence
1²²	Nonrandomized studies	0/6 (0.0)	0/14 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical
Bleeding (assessed with: unspecified)
1²⁷	Nonrandomized studies	2/4 (50.0)	0/9 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical
Major bleeding
1²²	Nonrandomized studies	1/6 (16.7)	1/14 (7.1)	RR, 2.33 (0.17-31.46)	95 more per 1000 (59 fewer to 1000 more)	⊕○○○ Very low∗,†	Critical
Clinically relevant non major bleeding
1²²	Nonrandomized studies	0/6 (0.0)	0/14 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality)
2²⁷^,²⁸	Nonrandomized studies	2/11 (18.2)	1/13 (7.7)	RD, 0.02 (−0.30 to 0.34)	20 more per 1000 (300 fewer to 340 more)	⊕○○○ Very low∗,†	Critical
Thrombus resolution (assessed with: complete or partial resolution)
3²²^,²⁷^,²⁸	Nonrandomized studies	15/17 (88.2)	25/27 (92.6)	RR, 1.01 (0.84-1.22)	9 more per 1000 (148 fewer to 204 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence
1²²	Nonrandomized studies	0/6 (0.0)	0/14 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical
Bleeding (assessed with: unspecified)
1²⁷	Nonrandomized studies	2/4 (50.0)	0/9 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical
Major bleeding
1²²	Nonrandomized studies	1/6 (16.7)	1/14 (7.1)	RR, 2.33 (0.17-31.46)	95 more per 1000 (59 fewer to 1000 more)	⊕○○○ Very low∗,†	Critical
Clinically relevant non major bleeding
1²²	Nonrandomized studies	0/6 (0.0)	0/14 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical

Risk of bias, assessed using ROBINS-I, was judged to be serious because of selection bias without adjustment for confounders.

Imprecision because of small number of included patients and patients with events in the included studies.