Table 4. GRADE summary of findings for... | American Society of Hematology

Table 4.

GRADE summary of findings for thrombolysis followed by AC vs AC alone in patients with extremity DVT

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality)
5^22-26	Nonrandomized studies	0/38 (0.0)	4/59 (6.8)	RD, −0.01 (−0.14 to 0.12)	10 fewer per 1000 (140 fewer to 120 more)	⊕○○○ Very low∗,†	Critical
Thrombus resolution (assessed with: complete or partial resolution)
4²²^,²³^,²⁵^,²⁶	Nonrandomized studies	21/26 (80.8)	41/53 (77.4)	RR, 1.00 (0.76-1.32)	0 fewer per 1000 (186 fewer to 248 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence
4^22-25	Nonrandomized studies	6/29 (20.7)	3/46 (6.5)	RD, 0.05 (−0.16 to 0.26)	50 more per 1000 (160 fewer to 260 more)	⊕○○○ Very low∗,†	Critical
Postthrombotic syndrome
4^23-26	Nonrandomized studies	13/36 (36.1)	13/34 (38.2)	RR, 0.92 (0.48-1.76)	31 fewer per 1000 (199 fewer to 291 more)	⊕○○○ Very low∗,†	Critical
Major bleeding
4²²^,²³^,²⁵^,²⁶	Nonrandomized studies	2/26 (7.7)	3/64 (4.7)	RD, 0.11 (−0.06 to 0.27)	110 more per 1000 (60 fewer to 270 more)	⊕○○○ Very low∗,†	Critical
Clinically relevant non major bleeding
4²²^,²³^,²⁵	Nonrandomized studies	0/17 (0.0)	1/51 (2.0)	RD, 0.00 (−0.21 to 0.21)	0 fewer per 1000 (210 fewer to 210 more)	⊕○○○ Very low∗,†	Critical

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality)
5^22-26	Nonrandomized studies	0/38 (0.0)	4/59 (6.8)	RD, −0.01 (−0.14 to 0.12)	10 fewer per 1000 (140 fewer to 120 more)	⊕○○○ Very low∗,†	Critical
Thrombus resolution (assessed with: complete or partial resolution)
4²²^,²³^,²⁵^,²⁶	Nonrandomized studies	21/26 (80.8)	41/53 (77.4)	RR, 1.00 (0.76-1.32)	0 fewer per 1000 (186 fewer to 248 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence
4^22-25	Nonrandomized studies	6/29 (20.7)	3/46 (6.5)	RD, 0.05 (−0.16 to 0.26)	50 more per 1000 (160 fewer to 260 more)	⊕○○○ Very low∗,†	Critical
Postthrombotic syndrome
4^23-26	Nonrandomized studies	13/36 (36.1)	13/34 (38.2)	RR, 0.92 (0.48-1.76)	31 fewer per 1000 (199 fewer to 291 more)	⊕○○○ Very low∗,†	Critical
Major bleeding
4²²^,²³^,²⁵^,²⁶	Nonrandomized studies	2/26 (7.7)	3/64 (4.7)	RD, 0.11 (−0.06 to 0.27)	110 more per 1000 (60 fewer to 270 more)	⊕○○○ Very low∗,†	Critical
Clinically relevant non major bleeding
4²²^,²³^,²⁵	Nonrandomized studies	0/17 (0.0)	1/51 (2.0)	RD, 0.00 (−0.21 to 0.21)	0 fewer per 1000 (210 fewer to 210 more)	⊕○○○ Very low∗,†	Critical

Risk of bias, assessed using ROBINS-I, was judged to be serious because of selection bias without adjustment for potential confounders.

Imprecision because of the small number of included patients and patients with events in the included studies.