Table 3. GRADE summary of evidence for... | American Society of Hematology

Table 3.

GRADE summary of evidence for thrombolysis followed by AC vs AC alone in patients with massive PE

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality)
2¹⁹^,²⁰	Nonrandomized studies	6/10 (50.0)	8/16 (50.0)	RR, 0.88 (0.42-1.85)	60 fewer per 1000 (290 fewer to 425 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence
1¹⁹	Nonrandomized studies	3/7 (42.9)	3/15 (20.0)	RR, 2.14 (0.57-8.09)	228 more per 1000 (86 fewer to 1000 more)	⊕○○○ Very low∗,†	Critical
Bleeding (assessed with: unspecified bleed [intracranial/extracranial])
1²⁰	Nonrandomized studies	1/7 (14.3)	0/1 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical

No. of studies	Study design	No. of patients (%)		Effect		Certainty	Importance
No. of studies	Study design	Thrombolysis followed by AC	AC alone	Relative (95% CI)	Absolute (95% CI)	Certainty	Importance
Mortality (assessed with: all-cause mortality)
2¹⁹^,²⁰	Nonrandomized studies	6/10 (50.0)	8/16 (50.0)	RR, 0.88 (0.42-1.85)	60 fewer per 1000 (290 fewer to 425 more)	⊕○○○ Very low∗,†	Critical
Thrombus recurrence
1¹⁹	Nonrandomized studies	3/7 (42.9)	3/15 (20.0)	RR, 2.14 (0.57-8.09)	228 more per 1000 (86 fewer to 1000 more)	⊕○○○ Very low∗,†	Critical
Bleeding (assessed with: unspecified bleed [intracranial/extracranial])
1²⁰	Nonrandomized studies	1/7 (14.3)	0/1 (0.0)	Not estimable	Not estimable	⊕○○○ Very low∗,†	Critical

Risk of bias, assessed using ROBINS-I, was judged to be serious because of selection bias without adjustment for potential confounders.

Imprecision because of the small number of included patients and patients with events in the included studies.