Function and patient-reported outcomes at 3 and 6 months by intervention arm
| Measures . | 3 months . | 6 months . | ||||
|---|---|---|---|---|---|---|
| PA (n = 24) . | Control (n = 27) . | P value . | PA (n = 20) . | Control (n = 22) . | P value . | |
| Mean (SE) . | Mean (SE) . | Mean (SE) . | Mean (SE) . | |||
| Physical function | ||||||
| SPPB (range, 0-12; impairment <9) (n=51 at 3 months; n=41 at 6 months) | 6.7 (0.9) | 6.9 (0.8) | 0.88 | 8.1 (0.9) | 8.2 (0.8) | 0.87 |
| Gait speed (m/s) | 0.9 (0.1) | 0.8 (0.1) | .66 | 0.8 (0.1) | 0.9 (0.1) | .98 |
| SPPB walk score | 2.5 (0.3) | 2.5 (0.3) | .90 | 2.9 (0.3) | 3.2 (0.3) | .49 |
| SPPB balance score | 2.5 (0.4) | 2.8 (0.3) | .53 | 2.9 (0.3) | 3.2 (0.3) | .62 |
| SPPB chair stand score | 1.8 (0.3) | 1.6 (0.3) | .62 | 2.2 (0.3) | 1.8 (0.3) | .41 |
| Grip strength (kg) (n = 44 at 3 months; n = 41 at 6 months) | ||||||
| Male | 30.5 (2.2) | 32.8 (2.2) | .48 | 30.2 (2.2) | 31.9 (2.0) | .57 |
| Female | 18.0 (3.1) | 19.0 (2.2) | .81 | 23.3 (3.8) | 16.9 (1.4) | .07 |
| PAT-D (range, 1-5; impairment >1) (n = 40 at 3 months; n = 38 at 6 months) | 2.1 (0.2) | 1.9 (0.2) | .53 | 2.0 (0.2) | 1.7 (.01) | .21 |
| Activities of Daily Living subscale (n = 47 at 3 months; n = 42 at 6 months) | 1.5 (0.1) | 1.4 (0.1) | .58 | 1.5 (0.1) | 1.5 (0.1) | .87 |
| Instrumental Activities of Daily Living subscale (n = 44 at 3 months; n = 39 at 6 months) | 2.0 (0.2) | 1.7 (0.2) | .45 | 1.7 (0.2) | 1.6 (0.2) | .68 |
| Mobility subscale (n = 45 at 3 months; n = 41 at 6 months) | 2.8 (0.3) | 2.8 (0.3) | .90 | 2.9 (0.3) | 2.3 (0.2) | .12 |
| MAT-SF (n = 46 at 3 months; n = 41 at 6 months) | 52.3 (2.8) | 50.1 (2.5) | .57 | 54.2 (2.3) | 53.7 (2.1) | .87 |
| QOL and symptoms | ||||||
| Distress thermometer (n = 46 at 3 months; n = 42 at 6 months) | 3.4 (0.6) | 2.7 (0.5) | .36 | 3.0 (0.6) | 2.6 (0.5) | .69 |
| CES-D (n = 46 at 3 months; n = 41 at 6 months) | 8.3 (1.3) | 8.2 (1.2) | .98 | 8.9 (1.6) | 8.3 (1.8) | .79 |
| FACT-Leu (n = 46 at 3 months; n = 42 at 6 months) | 129.4 (3.6) | 132.3 (3.4) | .57 | 132.4 (4.6) | 139.0 (3.6) | .31 |
| FACT-Emotional (n = 47 at 3 months; n = 42 at 6 months) | 19.0 (0.6) | 19.4 (0.6) | .60 | 19.6 (0.7) | 20.0 (0.6) | .70 |
| FACT-Functional (n = 46 at 3 months; n = 42 at 6 months) | 15.7 (1.1) | 16.2 (1.4) | .77 | 16.8 (1.3) | 19.0 (1.3) | .23 |
| FACT-G (n = 46 at 3 months; n = 42 at 6 months) | 80.9 (2.6) | 80.8 (2.4) | .98 | 81.9 (2.7) | 86.6 (2.9) | .25 |
| FACT-Physical (n = 47 at 3 months; n = 42 at 6 months) | 22.0 (1.3) | 21.6 (0.9) | .79 | 22.1 (1.2) | 22.5 (1.2) | .77 |
| FACT-Social (n = 47 at 3 months; n = 42 at 6 months) | 23.2 (0.8) | 23.6 (0.9) | .78 | 23.5 (0.9) | 25.0 (0.8) | .20 |
| FACT-Fatigue (n = 46 at 3 months; n = 42 at 6 months) | 35.6 (2.9) | 35.8 (1.8) | .96 | 37.6 (2.5) | 35.8 (2.5) | .63 |
| Digit symbol substitution test (n = 46 at 3 months; n = 42 at 6 months) | 46.8 (3.2) | 49.2 (2.8) | .57 | 44.9 (3.1) | 47.9 (4.1) | .57 |
| Measures . | 3 months . | 6 months . | ||||
|---|---|---|---|---|---|---|
| PA (n = 24) . | Control (n = 27) . | P value . | PA (n = 20) . | Control (n = 22) . | P value . | |
| Mean (SE) . | Mean (SE) . | Mean (SE) . | Mean (SE) . | |||
| Physical function | ||||||
| SPPB (range, 0-12; impairment <9) (n=51 at 3 months; n=41 at 6 months) | 6.7 (0.9) | 6.9 (0.8) | 0.88 | 8.1 (0.9) | 8.2 (0.8) | 0.87 |
| Gait speed (m/s) | 0.9 (0.1) | 0.8 (0.1) | .66 | 0.8 (0.1) | 0.9 (0.1) | .98 |
| SPPB walk score | 2.5 (0.3) | 2.5 (0.3) | .90 | 2.9 (0.3) | 3.2 (0.3) | .49 |
| SPPB balance score | 2.5 (0.4) | 2.8 (0.3) | .53 | 2.9 (0.3) | 3.2 (0.3) | .62 |
| SPPB chair stand score | 1.8 (0.3) | 1.6 (0.3) | .62 | 2.2 (0.3) | 1.8 (0.3) | .41 |
| Grip strength (kg) (n = 44 at 3 months; n = 41 at 6 months) | ||||||
| Male | 30.5 (2.2) | 32.8 (2.2) | .48 | 30.2 (2.2) | 31.9 (2.0) | .57 |
| Female | 18.0 (3.1) | 19.0 (2.2) | .81 | 23.3 (3.8) | 16.9 (1.4) | .07 |
| PAT-D (range, 1-5; impairment >1) (n = 40 at 3 months; n = 38 at 6 months) | 2.1 (0.2) | 1.9 (0.2) | .53 | 2.0 (0.2) | 1.7 (.01) | .21 |
| Activities of Daily Living subscale (n = 47 at 3 months; n = 42 at 6 months) | 1.5 (0.1) | 1.4 (0.1) | .58 | 1.5 (0.1) | 1.5 (0.1) | .87 |
| Instrumental Activities of Daily Living subscale (n = 44 at 3 months; n = 39 at 6 months) | 2.0 (0.2) | 1.7 (0.2) | .45 | 1.7 (0.2) | 1.6 (0.2) | .68 |
| Mobility subscale (n = 45 at 3 months; n = 41 at 6 months) | 2.8 (0.3) | 2.8 (0.3) | .90 | 2.9 (0.3) | 2.3 (0.2) | .12 |
| MAT-SF (n = 46 at 3 months; n = 41 at 6 months) | 52.3 (2.8) | 50.1 (2.5) | .57 | 54.2 (2.3) | 53.7 (2.1) | .87 |
| QOL and symptoms | ||||||
| Distress thermometer (n = 46 at 3 months; n = 42 at 6 months) | 3.4 (0.6) | 2.7 (0.5) | .36 | 3.0 (0.6) | 2.6 (0.5) | .69 |
| CES-D (n = 46 at 3 months; n = 41 at 6 months) | 8.3 (1.3) | 8.2 (1.2) | .98 | 8.9 (1.6) | 8.3 (1.8) | .79 |
| FACT-Leu (n = 46 at 3 months; n = 42 at 6 months) | 129.4 (3.6) | 132.3 (3.4) | .57 | 132.4 (4.6) | 139.0 (3.6) | .31 |
| FACT-Emotional (n = 47 at 3 months; n = 42 at 6 months) | 19.0 (0.6) | 19.4 (0.6) | .60 | 19.6 (0.7) | 20.0 (0.6) | .70 |
| FACT-Functional (n = 46 at 3 months; n = 42 at 6 months) | 15.7 (1.1) | 16.2 (1.4) | .77 | 16.8 (1.3) | 19.0 (1.3) | .23 |
| FACT-G (n = 46 at 3 months; n = 42 at 6 months) | 80.9 (2.6) | 80.8 (2.4) | .98 | 81.9 (2.7) | 86.6 (2.9) | .25 |
| FACT-Physical (n = 47 at 3 months; n = 42 at 6 months) | 22.0 (1.3) | 21.6 (0.9) | .79 | 22.1 (1.2) | 22.5 (1.2) | .77 |
| FACT-Social (n = 47 at 3 months; n = 42 at 6 months) | 23.2 (0.8) | 23.6 (0.9) | .78 | 23.5 (0.9) | 25.0 (0.8) | .20 |
| FACT-Fatigue (n = 46 at 3 months; n = 42 at 6 months) | 35.6 (2.9) | 35.8 (1.8) | .96 | 37.6 (2.5) | 35.8 (2.5) | .63 |
| Digit symbol substitution test (n = 46 at 3 months; n = 42 at 6 months) | 46.8 (3.2) | 49.2 (2.8) | .57 | 44.9 (3.1) | 47.9 (4.1) | .57 |