Side effects of T/L in the safety cohort (n = 99)
| . | Any grade . | Grade 1-2 . | Grade 3-4 . |
|---|---|---|---|
| Hematologic toxicity | |||
| Neutropenia | 51 (55) | 12 (13) | 39 (42) |
| Anemia | 49 (53) | 30 (33%) | 19 (21) |
| Thrombocytopenia | 42 (46) | 25 (27) | 17 (18) |
| Infectious toxicity | |||
| Febrile neutropenia | 17 (18) | 4 (4) | 13 (14) |
| Infection | 46 (49) | 20 (21) | 26 (28) |
| Fever | 22 (24) | 14 (15) | 8 (9) |
| Gastrointestinal toxicity | |||
| Diarrhea | 26 (28) | 23 (24) | 3 (3) |
| Constipation | 5 (5) | 5 (5) | 0 (0) |
| Anorexia | 26 (29) | 19 (21) | 7 (8) |
| Renal toxicity | |||
| Renal failure | 19 (20) | 16 (17) | 3 (3) |
| Thrombotic toxicity | |||
| Deep venous thrombosis | 4 (4) | 2 (2) | 2 (2) |
| Pulmonary thromboembolism | 3 (3) | 1 (1) | 2 (2) |
| Other toxicity | |||
| Infusion reactions | 1 (1) | 1 (1) | 0 (0) |
| Skin rash | 16 (17) | 10 (11) | 6 (6) |
| Asthenia | 53 (58) | 39 (42) | 14 (15) |
| Cough | 15 (16) | 12 (13) | 3 (3) |
| Peripheral edema | 12 (13) | 11 (12) | 1 (1) |
| . | Any grade . | Grade 1-2 . | Grade 3-4 . |
|---|---|---|---|
| Hematologic toxicity | |||
| Neutropenia | 51 (55) | 12 (13) | 39 (42) |
| Anemia | 49 (53) | 30 (33%) | 19 (21) |
| Thrombocytopenia | 42 (46) | 25 (27) | 17 (18) |
| Infectious toxicity | |||
| Febrile neutropenia | 17 (18) | 4 (4) | 13 (14) |
| Infection | 46 (49) | 20 (21) | 26 (28) |
| Fever | 22 (24) | 14 (15) | 8 (9) |
| Gastrointestinal toxicity | |||
| Diarrhea | 26 (28) | 23 (24) | 3 (3) |
| Constipation | 5 (5) | 5 (5) | 0 (0) |
| Anorexia | 26 (29) | 19 (21) | 7 (8) |
| Renal toxicity | |||
| Renal failure | 19 (20) | 16 (17) | 3 (3) |
| Thrombotic toxicity | |||
| Deep venous thrombosis | 4 (4) | 2 (2) | 2 (2) |
| Pulmonary thromboembolism | 3 (3) | 1 (1) | 2 (2) |
| Other toxicity | |||
| Infusion reactions | 1 (1) | 1 (1) | 0 (0) |
| Skin rash | 16 (17) | 10 (11) | 6 (6) |
| Asthenia | 53 (58) | 39 (42) | 14 (15) |
| Cough | 15 (16) | 12 (13) | 3 (3) |
| Peripheral edema | 12 (13) | 11 (12) | 1 (1) |
Data are presented as n (%).