Potentially novel genome-wide significant VTE loci
| Variant (risk-increasing allele/non–risk-increasing allele) . | Risk allele frequency in GBMI . | Risk allele frequency by ancestry in gnomAD 4.1.0 . | Odds ratio . | P value . | Prioritized gene . |
|---|---|---|---|---|---|
| chr1:12563482 rs112106699 a/g | 0.004 | AMR, 0.0082; AFR, 0.088; FIN, 0.00; NFE, 0.00078 | 1.57 | 2 × 10–8 | DHRS3 Dehydrogenase/reductase 3 |
| chr11:100637868 rs11224340 g/a | 0.90 | AMR, 0.93; AFR, 0.98; FIN, 0.90; NFE, 0.91 | 1.09 | 3 × 10–8 | ARHGAP4 Rho GTPase activating protein 4 |
| chr12:127502539 rs115924439 a/g | 0.002 | AMR, 0.0031; AFR, 0.038; FIN, 0.00; NFE, 0.000088 | 1.92 | 2 × 10–8 | LINC02411 Long intergenic nonprotein coding RNA 2411 |
| chr17:48539858 rs1459062246 166-bp insertion | 0.80 | AMR, 0.80; AFR, 0.54; FIN, 0.77; NFE, 0.78 | 1.12 | 3 × 10–8 | HOXB2 Homeobox B2 |
| Variant (risk-increasing allele/non–risk-increasing allele) . | Risk allele frequency in GBMI . | Risk allele frequency by ancestry in gnomAD 4.1.0 . | Odds ratio . | P value . | Prioritized gene . |
|---|---|---|---|---|---|
| chr1:12563482 rs112106699 a/g | 0.004 | AMR, 0.0082; AFR, 0.088; FIN, 0.00; NFE, 0.00078 | 1.57 | 2 × 10–8 | DHRS3 Dehydrogenase/reductase 3 |
| chr11:100637868 rs11224340 g/a | 0.90 | AMR, 0.93; AFR, 0.98; FIN, 0.90; NFE, 0.91 | 1.09 | 3 × 10–8 | ARHGAP4 Rho GTPase activating protein 4 |
| chr12:127502539 rs115924439 a/g | 0.002 | AMR, 0.0031; AFR, 0.038; FIN, 0.00; NFE, 0.000088 | 1.92 | 2 × 10–8 | LINC02411 Long intergenic nonprotein coding RNA 2411 |
| chr17:48539858 rs1459062246 166-bp insertion | 0.80 | AMR, 0.80; AFR, 0.54; FIN, 0.77; NFE, 0.78 | 1.12 | 3 × 10–8 | HOXB2 Homeobox B2 |
Meta-analysis identified 38 genome-wide significant loci, 4 are potentially novel.
AFR, African ancestry as defined by gnomAD; AMR, Admixed American ancestry; FIN, Finnish ancestry; NFE, non-Finnish EUR.