Demographic, clinical, and laboratory characteristics, and pregnancy study time of 33 women with SCD, followed up from ≤16 weeks gestation to 1 year after childbirth
| Characteristic∗ . | Total (N = 33) . |
|---|---|
| Age at enrollment, y | 31.0 (27.0-33.0) |
| Parity, n (%) | |
| 0 | 15 (45.5) |
| 1 | 13 (39.4) |
| 2 | 5 (15.2) |
| Baseline Hb level, g/dL | 8.6 (6.8-9.8) |
| Baseline reticulocyte count, % | 4.0 (3.0-5.2) |
| Body mass index, kg/m2 | 23.3 (20.6-26.8) |
| Type of pregnancy | |
| Singleton pregnancy, n (%) | 32 (97.0) |
| Multiple pregnancies (twin gestation), n (%) | 1 (3.0) |
| Gestational age at enrollment, wk | 12.7 (10.0-14.7) |
| Gestational age at enrollment by trimester, wk | |
| First trimester (up to 13 weeks), n (%) | 19 (57.6) |
| Second trimester (13 weeks 1 day up to 16 weeks), n (%) | 14 (42.4) |
| Gestational age at delivery, wk | 37.4 (36.5-38.6) |
| Mode of delivery | |
| Cesarean, n (%) | 13 (39.4) |
| Vaginal, n (%) | 20 (60.6) |
| SCD pregnancy outcomes | |
| ACS, n (%) | 0 (0.0) |
| Venous thromboembolism, n (%) | 0 (0.0) |
| Severe symptomatic anemia, n (%) | 5 (15.2) |
| Postpartum hemorrhage, n (%) | 6 (18.2) |
| Urinary tract infection, n (%) | 11 (33.3) |
| Maternal mortality, n (%) | 0 (0.0) |
| Fetal outcomes (n = 34) | |
| Intrauterine fetal death, n (%) | 0 (0.0) |
| Stillbirth, n (%) | 0 (0.0) |
| Alive, n (%) | 34 (100.0) |
| Preterm birth (≤37 weeks), n (%) | 12 (36.4) |
| Birth weight, kg | 2.9 (2.6-3.1) |
| Low birth weight (<2500 g), n (%) | 7 (20.6) |
| Perinatal mortality, n (%) | 1 (2.9) |
| Perinatal deaths per 1000 total births | 29.4 (0.7-153.3) |
| Characteristic∗ . | Total (N = 33) . |
|---|---|
| Age at enrollment, y | 31.0 (27.0-33.0) |
| Parity, n (%) | |
| 0 | 15 (45.5) |
| 1 | 13 (39.4) |
| 2 | 5 (15.2) |
| Baseline Hb level, g/dL | 8.6 (6.8-9.8) |
| Baseline reticulocyte count, % | 4.0 (3.0-5.2) |
| Body mass index, kg/m2 | 23.3 (20.6-26.8) |
| Type of pregnancy | |
| Singleton pregnancy, n (%) | 32 (97.0) |
| Multiple pregnancies (twin gestation), n (%) | 1 (3.0) |
| Gestational age at enrollment, wk | 12.7 (10.0-14.7) |
| Gestational age at enrollment by trimester, wk | |
| First trimester (up to 13 weeks), n (%) | 19 (57.6) |
| Second trimester (13 weeks 1 day up to 16 weeks), n (%) | 14 (42.4) |
| Gestational age at delivery, wk | 37.4 (36.5-38.6) |
| Mode of delivery | |
| Cesarean, n (%) | 13 (39.4) |
| Vaginal, n (%) | 20 (60.6) |
| SCD pregnancy outcomes | |
| ACS, n (%) | 0 (0.0) |
| Venous thromboembolism, n (%) | 0 (0.0) |
| Severe symptomatic anemia, n (%) | 5 (15.2) |
| Postpartum hemorrhage, n (%) | 6 (18.2) |
| Urinary tract infection, n (%) | 11 (33.3) |
| Maternal mortality, n (%) | 0 (0.0) |
| Fetal outcomes (n = 34) | |
| Intrauterine fetal death, n (%) | 0 (0.0) |
| Stillbirth, n (%) | 0 (0.0) |
| Alive, n (%) | 34 (100.0) |
| Preterm birth (≤37 weeks), n (%) | 12 (36.4) |
| Birth weight, kg | 2.9 (2.6-3.1) |
| Low birth weight (<2500 g), n (%) | 7 (20.6) |
| Perinatal mortality, n (%) | 1 (2.9) |
| Perinatal deaths per 1000 total births | 29.4 (0.7-153.3) |
Forty women with SCD were recruited into the study. After enrollment, 7 of 40 participants (17.5%) were lost to follow-up and completed no eDiary mobile application entries. A total of 33 of 40 participants (82.5%) completed the eDiary mobile application during the pregnancy interval (third trimester to 6 weeks after childbirth) and the after-pregnancy interval (beginning at 6 months to end of 9 months after childbirth). Table 1, therefore, includes data for only the 33 participants who completed the eDiary entries.
N = 33 except as noted for fetal outcomes; 1 participant had a twin gestation.
The term “baseline” in this table refers to reporting data at the time of enrollment, ≤16 weeks gestation.
Median (IQR) for continuous variables; count (%) for categorical variables.