Table 3.

Cancer-directed treatments separated into first-line treatments and R/R treatments by the number of studies in each group

First-line treatment–focused studies (N = 83)n (%)
Chemotherapy  
ABVD 59 (71) 
MOPP, COPP, or BEACOPP 15 (18) 
CVPP or AOPE 1 (1) 
EVAP 1 (1) 
Other 2 (2) 
Unspecified 5 (6) 
Radiotherapy  
Widely used 58 (70) 
Rarely used 10 (12) 
Not used or not reported 15 (18) 
R/R HL studies (N = 29)  
Primary advanced treatments used  
High-dose chemotherapy and ASCT 18 (62) 
Nivolumab 3 (10) 
Brentuximab vedotin 3 (10) 
Sintilimab 1 (3) 
Zimberelimab (GSL-010) 1 (3) 
Everolimus 1 (3) 
Allogeneic SCT 1 (3) 
ABVD 1 (3) 
Other 1 (3) 
Radiotherapy  
Widely used 17 (59) 
Rarely used or not used 12 (41) 
First-line treatment–focused studies (N = 83)n (%)
Chemotherapy  
ABVD 59 (71) 
MOPP, COPP, or BEACOPP 15 (18) 
CVPP or AOPE 1 (1) 
EVAP 1 (1) 
Other 2 (2) 
Unspecified 5 (6) 
Radiotherapy  
Widely used 58 (70) 
Rarely used 10 (12) 
Not used or not reported 15 (18) 
R/R HL studies (N = 29)  
Primary advanced treatments used  
High-dose chemotherapy and ASCT 18 (62) 
Nivolumab 3 (10) 
Brentuximab vedotin 3 (10) 
Sintilimab 1 (3) 
Zimberelimab (GSL-010) 1 (3) 
Everolimus 1 (3) 
Allogeneic SCT 1 (3) 
ABVD 1 (3) 
Other 1 (3) 
Radiotherapy  
Widely used 17 (59) 
Rarely used or not used 12 (41) 

AOPE, cytarabine, vincristine, cisplatin, and etoposide; EVAP, etoposide, vinbastine, doxorubucin, and prednisone; BEACOPP, bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone; COPP, cyclophosphamide, vincristine, procarbazine, and prednisone; CVPP, cyclophosphamide, vinblastine, procarbazine, and prednisone; MOPP, mechlorethamin, vincristine, procarbazine, and prednisone.

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