Comparative analyses of immunoglobulin RT replacement strategies with bsAb therapy in MM
| Study . | Approach 1 . | Approach 2 . | Summarized efficacy-related outcomes . |
|---|---|---|---|
| Lancman et al28 | Primary prophylaxis∗ | No treatment∗ | 90% reduction in the incidence of grade ≥3 infections while receiving primary prophylaxis |
| Cheruvalath et al37 | Primary prophylaxis | Preemptive or postinfection treatment | Improved PFS and OS with primary prophylaxis; OS benefit remained significant in multivariate analyses |
| Frerichs et al38 | Preemptive treatment | Postinfection treatment | Significant lower cumulative risk of grade ≥3 infections (5.3% vs 54.8% at 6 months) with IgRT usage |
| Mohan et al29 | Preemptive treatment | Postinfection treatment | Significantly lower cumulative risk of grade ≥3 infections (17% vs 43% at 6 months) with IgRT usage |
| Study . | Approach 1 . | Approach 2 . | Summarized efficacy-related outcomes . |
|---|---|---|---|
| Lancman et al28 | Primary prophylaxis∗ | No treatment∗ | 90% reduction in the incidence of grade ≥3 infections while receiving primary prophylaxis |
| Cheruvalath et al37 | Primary prophylaxis | Preemptive or postinfection treatment | Improved PFS and OS with primary prophylaxis; OS benefit remained significant in multivariate analyses |
| Frerichs et al38 | Preemptive treatment | Postinfection treatment | Significant lower cumulative risk of grade ≥3 infections (5.3% vs 54.8% at 6 months) with IgRT usage |
| Mohan et al29 | Preemptive treatment | Postinfection treatment | Significantly lower cumulative risk of grade ≥3 infections (17% vs 43% at 6 months) with IgRT usage |
We define primary prophylaxis as IgRT initiation regardless of IgG levels or infection history. We define preemptive treatment as IgRT initiation once serum IgG falls below 400 mg/dL (4 g/L). Postinfection treatment refers to IgRT initiation after an infection as occurred.
OS, overall survival; PFS, progression-free survival.
This study compared infections during months in which patients were receiving IVIG vs months in which patients were not receiving IVIG; however, when IVIG was prescribed, it was prescribed as primary prophylaxis.