Patients’ baseline characteristics according to CXCR4 mutational status
| Variable . | CXCR4 WT (n = 104) . | CXCR4 MUT (n = 70) . | P value . |
|---|---|---|---|
| Median age (range), y | 66 (55-71) | 66 (56-71) | .48 |
| Age >65 y, n (%) | 56 (54) | 41 (59) | .54 |
| Male sex, n (%) | 75 (72) | 46 (66) | .37 |
| Median hemoglobin (range), g/L | 102 (94-116) | 108 (99-120) | .10 |
| Hemoglobin <115 g/L, n (%) | 76 (73.8) | 46 (67.6) | .38 |
| Median platelet count (range), 103/μL | 252 (174-329) | 184 (121-247) | .001 |
| Platelet count <100 103/μL, n (%) | 4 (4) | 11 (17) | .004 |
| Median beta-2-microglobulin (range), mg/L | 5.0 (3.3-7.2) | 4.0 (3.0-7.0) | .082 |
| Beta-2-microglobulin >3.5 mg/L, n (%) | 88 (85) | 51 (73) | .058 |
| Median serum IgM (range), g/L | 33.6 (20.8-51.3) | 43.1 (32.5-58.7) | .011 |
| Serum IgM >70 g/L, n (%) | 5 (5) | 3 (4) | .87 |
| Previously treated, n (%) | 70 (67) | 41 (59) | .24 |
| Ibrutinib + rituximab, n (%) | 32 (31) | 26 (37) | .38 |
| Low IPSSWM, n (%) | 19 (18) | 9 (14) | .63 |
| Intermediate IPSSWM, n (%) | 42 (41) | 31 (47) | |
| High IPSSWM, n (%) | 42 (41) | 26 (39) |
| Variable . | CXCR4 WT (n = 104) . | CXCR4 MUT (n = 70) . | P value . |
|---|---|---|---|
| Median age (range), y | 66 (55-71) | 66 (56-71) | .48 |
| Age >65 y, n (%) | 56 (54) | 41 (59) | .54 |
| Male sex, n (%) | 75 (72) | 46 (66) | .37 |
| Median hemoglobin (range), g/L | 102 (94-116) | 108 (99-120) | .10 |
| Hemoglobin <115 g/L, n (%) | 76 (73.8) | 46 (67.6) | .38 |
| Median platelet count (range), 103/μL | 252 (174-329) | 184 (121-247) | .001 |
| Platelet count <100 103/μL, n (%) | 4 (4) | 11 (17) | .004 |
| Median beta-2-microglobulin (range), mg/L | 5.0 (3.3-7.2) | 4.0 (3.0-7.0) | .082 |
| Beta-2-microglobulin >3.5 mg/L, n (%) | 88 (85) | 51 (73) | .058 |
| Median serum IgM (range), g/L | 33.6 (20.8-51.3) | 43.1 (32.5-58.7) | .011 |
| Serum IgM >70 g/L, n (%) | 5 (5) | 3 (4) | .87 |
| Previously treated, n (%) | 70 (67) | 41 (59) | .24 |
| Ibrutinib + rituximab, n (%) | 32 (31) | 26 (37) | .38 |
| Low IPSSWM, n (%) | 19 (18) | 9 (14) | .63 |
| Intermediate IPSSWM, n (%) | 42 (41) | 31 (47) | |
| High IPSSWM, n (%) | 42 (41) | 26 (39) |
MUT, mutated; WT, wild-type.