Patients’ baseline characteristics according to treatment group
| Variable . | Ibrutinib monotherapy (n = 116) . | Ibrutinib + rituximab (n = 58) . | P value . |
|---|---|---|---|
| Median age (range), y | 66 (56-71) | 66 (55-77) | .74 |
| Age >65 y, n (%) | 61 (53) | 36 (62) | .24 |
| Male sex, n (%) | 87 (75) | 34 (59) | .03 |
| Median hemoglobin (range), g/L | 105 (96-119) | 103 (92-116) | .50 |
| Hemoglobin <115 g/L, n (%) | 81 (70) | 41 (73) | .71 |
| Median platelet count (range), 103/μL | 215 (150-282) | 242 (166-340) | .15 |
| Platelet count <100 103/μL, n (%) | 11 (10) | 4 (8) | .67 |
| Median beta-2-microglobulin (range), mg/L | 5.2 (3.3-7.5) | 3.8 (3.0-5.0) | .001 |
| Beta-2-microglobulin >3.5 mg/L, n (%) | 96 (83) | 43 (74) | .18 |
| Median serum IgM (range), g/L | 38.4 (27.4-55.6) | 35.8 (18.2-51.4) | .17 |
| Serum IgM >70 g/L, n (%) | 8 (7) | 0 (0) | .04 |
| Previously treated, n (%) | 84 (72) | 27 (47) | .001 |
| CXCR4 mutations, n (%) | 44 (38) | 26 (45) | .38 |
| Low IPSSWM, n (%) | 21 (18) | 7 (13) | .67 |
| Intermediate IPSSWM, n (%) | 48 (42) | 25 (46) | |
| High IPSSWM, n (%) | 46 (40) | 22 (41) |
| Variable . | Ibrutinib monotherapy (n = 116) . | Ibrutinib + rituximab (n = 58) . | P value . |
|---|---|---|---|
| Median age (range), y | 66 (56-71) | 66 (55-77) | .74 |
| Age >65 y, n (%) | 61 (53) | 36 (62) | .24 |
| Male sex, n (%) | 87 (75) | 34 (59) | .03 |
| Median hemoglobin (range), g/L | 105 (96-119) | 103 (92-116) | .50 |
| Hemoglobin <115 g/L, n (%) | 81 (70) | 41 (73) | .71 |
| Median platelet count (range), 103/μL | 215 (150-282) | 242 (166-340) | .15 |
| Platelet count <100 103/μL, n (%) | 11 (10) | 4 (8) | .67 |
| Median beta-2-microglobulin (range), mg/L | 5.2 (3.3-7.5) | 3.8 (3.0-5.0) | .001 |
| Beta-2-microglobulin >3.5 mg/L, n (%) | 96 (83) | 43 (74) | .18 |
| Median serum IgM (range), g/L | 38.4 (27.4-55.6) | 35.8 (18.2-51.4) | .17 |
| Serum IgM >70 g/L, n (%) | 8 (7) | 0 (0) | .04 |
| Previously treated, n (%) | 84 (72) | 27 (47) | .001 |
| CXCR4 mutations, n (%) | 44 (38) | 26 (45) | .38 |
| Low IPSSWM, n (%) | 21 (18) | 7 (13) | .67 |
| Intermediate IPSSWM, n (%) | 48 (42) | 25 (46) | |
| High IPSSWM, n (%) | 46 (40) | 22 (41) |