mRNA levels of vascular, STAT1/3, and bone-related genes in cortical bone from 6-week-old control (Dmp1Cre) and Dmp1Cre.Socs3f/f mice treated with IgG or αLy6G for 2 weeks
| . | Dmp1Cre . | Dmp1Cre.Socs3f/f . | ANOVA result . | ||
|---|---|---|---|---|---|
| IgG . | αLy6G . | IgG . | αLy6G . | ||
| Sample number | 8 | 8 | 8 | 8 | |
| Emcn (endomucin) | 0.175 ± 0.022 | 0.123 ± 0.013 | 0.214 ± 0.018∗ | 0.193 ± 0.032 | Genotype, .023; αLy6G, .112; interaction, .482 |
| Vegfa | 1.31 ± 0.30 | 1.61 ± 0.61 | 1.49 ± 0.21 | 3.73 ± 1.32 | Genotype, .136; αLy6G, .101; interaction, .206 |
| Tie1 | 0.018 ± 0.003 | 0.021 ± 0.002 | 0.028 ± 0.003∗ | 0.022 ± 0.002 | Genotype, .021; αLy6G, .559; interaction, .095 |
| Bcl3 | 0.047 ± 0.004 | 0.071 ± 0.013 | 0.066 ± 0.011 | 0.059 ± 0.008 | genotype, .723; αLy6G, .355; interaction, .095 |
| Socs1 | 0.012 ± 0.001 | 0.013 ± 0.001 | 0.019 ± 0.002∗∗∗ | 0.016 ± 0.001 | Genotype, .0002; αLy6G, .301; interaction, .164 |
| Bglap1 (osteocalcin) | 2.79 ± 0.36 | 1.83 ± 0.23 | 5.12 ± 0.67∗∗ | 4.00 ± 0.52 | Genotype, <.0001; αLy6G,: .036; interaction, .863 |
| Pdpln (podoplanin) | 0.072 ± 0.009 | 0.049 ± 0.006 | 0.118 ± 0.016 | 0.085 ± 0.017 | Genotype, .004; αLy6G, .040; interaction, .726 |
| . | Dmp1Cre . | Dmp1Cre.Socs3f/f . | ANOVA result . | ||
|---|---|---|---|---|---|
| IgG . | αLy6G . | IgG . | αLy6G . | ||
| Sample number | 8 | 8 | 8 | 8 | |
| Emcn (endomucin) | 0.175 ± 0.022 | 0.123 ± 0.013 | 0.214 ± 0.018∗ | 0.193 ± 0.032 | Genotype, .023; αLy6G, .112; interaction, .482 |
| Vegfa | 1.31 ± 0.30 | 1.61 ± 0.61 | 1.49 ± 0.21 | 3.73 ± 1.32 | Genotype, .136; αLy6G, .101; interaction, .206 |
| Tie1 | 0.018 ± 0.003 | 0.021 ± 0.002 | 0.028 ± 0.003∗ | 0.022 ± 0.002 | Genotype, .021; αLy6G, .559; interaction, .095 |
| Bcl3 | 0.047 ± 0.004 | 0.071 ± 0.013 | 0.066 ± 0.011 | 0.059 ± 0.008 | genotype, .723; αLy6G, .355; interaction, .095 |
| Socs1 | 0.012 ± 0.001 | 0.013 ± 0.001 | 0.019 ± 0.002∗∗∗ | 0.016 ± 0.001 | Genotype, .0002; αLy6G, .301; interaction, .164 |
| Bglap1 (osteocalcin) | 2.79 ± 0.36 | 1.83 ± 0.23 | 5.12 ± 0.67∗∗ | 4.00 ± 0.52 | Genotype, <.0001; αLy6G,: .036; interaction, .863 |
| Pdpln (podoplanin) | 0.072 ± 0.009 | 0.049 ± 0.006 | 0.118 ± 0.016 | 0.085 ± 0.017 | Genotype, .004; αLy6G, .040; interaction, .726 |
Effect of genotype: ∗P < .05; ∗∗P < .01; ∗∗∗P < .001 vs Dmp1Cre IgG, by 2-way ANOVA with Šidák multiple comparisons test. Bold type indicates a significant P value.
ANOVA, analysis of variance.