Studies showing comparison of outcomes between up-front alternative donor HCT with IST and salvage HCT
| Study . | No. of patients . | Age at diagnosis/HCT, median (range), y . | Comparison up-front HCT vs IST . | Comparison up-front MUD vs salvage HCT . |
|---|---|---|---|---|
| Dufour et al6 | Up-front HCT: 29 ∗IST: 58 ∗Salvage HCT: 24 | At diagnosis Up-front: 7.9 (0.5-18.6) At HCT Up-front: 8.4 (1.7-19.1) | 2-year OS Up-front HCT: 96% ± 4% IST: 94% ± 3% (P = .68) 2-year EFS Up-front HCT: 92% ± 5% IST: 40% ± 7% (P = .0001) | 2-year OS and EFS Up-front MUD HCT: 95% ± 5% Salvage MUD HCT: 74% ± 9% (P = .02) |
| Choi et al16 | Up-front HCT: 23 IST: 19 Salvage HCT: 11 | At diagnosis Up-front HCT: 9.3 (0.6-17.2) IST 8.5 (1.3-14.1) Salvage HCT: 6.8 (1.3-11.6) At HCT Up-front: 11.5 (1.1-17.7) Salvage: 8.1 (2.7-14.9) | OS Up-front HCT: 91.3% IST: 71.2% (P = .187) FFS HCT: 91.3% IST: 30.7% (P < .001) | 5-year EFS Up-front HCT: 91.3% Salvage HCT: 50.9% (P = .015) |
| Cheng et al15 | Up-front HCT: 28 IST: 24 | At diagnosis HCT: 8 (2-17) IST: 6 (4-16) | 10-year OS Up-front HCT: 89.3% ± 5.8% IST: 73.4% ± 12.6% (P = .806) FFS HCT: 89.3% ± 5.8% IST: 52.6% ± 10.5% (P = .008) | N/A |
| Xu et al17 | Up-front HCT: 76 IST: 37 | At diagnosis HCT: 28 (18-49) IST: 32 (18-62) | 8-year OS Up-front HCT: 83.7% IST: 75.6% (P = .328) FFS HCT: 83.7% ± 4.8% IST: 38.5% ± 13.2% (P = .001) | N/A |
| Xu et al36 | Up-front HCT: 23 Salvage HCT: 29 | All pediatric patients (<18 years) | N/A | OS: P = .698 FFS: P = .899 |
| Yang et al18 | Up-front HCT: 20 IST: 29 | At diagnosis Up-front HCT: 13 (4-18) IST: 12 (4-17) Salvage HCT: 12 (4-17) | 3-year OS Up-front HCT: 85.0% ± 8.0% IST: 79.3% ± 7.5% (P = .740) 3-year FFS HCT: 80.0% ± 8.9% IST: 35.9% ± 10.9% (P = .043) | EFS Up-front HCT: 80.0% ± 8.9% Salvage HCT: 41.7% ± 14.2% (P = .046) |
| Wu et al37 | Up-front HCT: 114 IST: 99 | At diagnosis Up-front HCT: 27.5 (15-54) IST: 31 (15-55) | OS Up-front HCT: 86.5% (95% CI, 79.7-93.8) IST: 92.4% (95% CI, 87.2-98.0) FFS HCT: 86.5% (95% CI, 79.7-93.8) | N/A |
| Study . | No. of patients . | Age at diagnosis/HCT, median (range), y . | Comparison up-front HCT vs IST . | Comparison up-front MUD vs salvage HCT . |
|---|---|---|---|---|
| Dufour et al6 | Up-front HCT: 29 ∗IST: 58 ∗Salvage HCT: 24 | At diagnosis Up-front: 7.9 (0.5-18.6) At HCT Up-front: 8.4 (1.7-19.1) | 2-year OS Up-front HCT: 96% ± 4% IST: 94% ± 3% (P = .68) 2-year EFS Up-front HCT: 92% ± 5% IST: 40% ± 7% (P = .0001) | 2-year OS and EFS Up-front MUD HCT: 95% ± 5% Salvage MUD HCT: 74% ± 9% (P = .02) |
| Choi et al16 | Up-front HCT: 23 IST: 19 Salvage HCT: 11 | At diagnosis Up-front HCT: 9.3 (0.6-17.2) IST 8.5 (1.3-14.1) Salvage HCT: 6.8 (1.3-11.6) At HCT Up-front: 11.5 (1.1-17.7) Salvage: 8.1 (2.7-14.9) | OS Up-front HCT: 91.3% IST: 71.2% (P = .187) FFS HCT: 91.3% IST: 30.7% (P < .001) | 5-year EFS Up-front HCT: 91.3% Salvage HCT: 50.9% (P = .015) |
| Cheng et al15 | Up-front HCT: 28 IST: 24 | At diagnosis HCT: 8 (2-17) IST: 6 (4-16) | 10-year OS Up-front HCT: 89.3% ± 5.8% IST: 73.4% ± 12.6% (P = .806) FFS HCT: 89.3% ± 5.8% IST: 52.6% ± 10.5% (P = .008) | N/A |
| Xu et al17 | Up-front HCT: 76 IST: 37 | At diagnosis HCT: 28 (18-49) IST: 32 (18-62) | 8-year OS Up-front HCT: 83.7% IST: 75.6% (P = .328) FFS HCT: 83.7% ± 4.8% IST: 38.5% ± 13.2% (P = .001) | N/A |
| Xu et al36 | Up-front HCT: 23 Salvage HCT: 29 | All pediatric patients (<18 years) | N/A | OS: P = .698 FFS: P = .899 |
| Yang et al18 | Up-front HCT: 20 IST: 29 | At diagnosis Up-front HCT: 13 (4-18) IST: 12 (4-17) Salvage HCT: 12 (4-17) | 3-year OS Up-front HCT: 85.0% ± 8.0% IST: 79.3% ± 7.5% (P = .740) 3-year FFS HCT: 80.0% ± 8.9% IST: 35.9% ± 10.9% (P = .043) | EFS Up-front HCT: 80.0% ± 8.9% Salvage HCT: 41.7% ± 14.2% (P = .046) |
| Wu et al37 | Up-front HCT: 114 IST: 99 | At diagnosis Up-front HCT: 27.5 (15-54) IST: 31 (15-55) | OS Up-front HCT: 86.5% (95% CI, 79.7-93.8) IST: 92.4% (95% CI, 87.2-98.0) FFS HCT: 86.5% (95% CI, 79.7-93.8) | N/A |
CI, confidence interval; EFS, event-free survival; FFS, failure-free survival; N/A, not applicable; OS, overall survival.
Matched historical controls.