Multivariate analysis of severe anemia during the post–CAR-T period
| Characteristic . | Severe anemia, early post–CAR-T period n = 129 (55 events) . | Severe anemia, late post–CAR-T period n = 115 (19 events) . | ||||
|---|---|---|---|---|---|---|
| OR . | 95% CI . | P value . | OR . | 95% CI . | P value . | |
| Age, y (cont.) | 1.01 | 0.96-1.06 | .76 | |||
| Sex, female | 2.84 | 1.25-6.70 | .014 | |||
| Center, United States | 1.81 | 0.80-4.15 | .16 | 0.39 | 0.10-1.32 | .15 |
| Previous therapy lines >5, yes | 0.83 | 0.37-1.84 | .65 | |||
| PD before LD, yes | 2.12 | 0.96-4.83 | .067 | 9.63 | 2.50-56.3 | .003 |
| Grade ≥3 neutropenia, thrombocytopenia, and/or anemia before LD: yes | 4.97 | 1.52-19.0 | .011 | 4.54 | 1.02-21.3 | .045 |
| CRS grade ≥2, yes | 2.58 | 1.12-6.09 | .027 | |||
| BT: intensive CTX, yes | 0.86 | 0.24-2.89 | .81 | 7.23 | 1.53-40.7 | .015 |
| Characteristic . | Severe anemia, early post–CAR-T period n = 129 (55 events) . | Severe anemia, late post–CAR-T period n = 115 (19 events) . | ||||
|---|---|---|---|---|---|---|
| OR . | 95% CI . | P value . | OR . | 95% CI . | P value . | |
| Age, y (cont.) | 1.01 | 0.96-1.06 | .76 | |||
| Sex, female | 2.84 | 1.25-6.70 | .014 | |||
| Center, United States | 1.81 | 0.80-4.15 | .16 | 0.39 | 0.10-1.32 | .15 |
| Previous therapy lines >5, yes | 0.83 | 0.37-1.84 | .65 | |||
| PD before LD, yes | 2.12 | 0.96-4.83 | .067 | 9.63 | 2.50-56.3 | .003 |
| Grade ≥3 neutropenia, thrombocytopenia, and/or anemia before LD: yes | 4.97 | 1.52-19.0 | .011 | 4.54 | 1.02-21.3 | .045 |
| CRS grade ≥2, yes | 2.58 | 1.12-6.09 | .027 | |||
| BT: intensive CTX, yes | 0.86 | 0.24-2.89 | .81 | 7.23 | 1.53-40.7 | .015 |
Significant P values are set in boldface.