Table 3. Unadjusted and adjusted Cox... | American Society of Hematology

Table 3.

Unadjusted and adjusted Cox regression analyses to identify predictors of OS after second-line therapy

	Unadjusted		Adjusted∗
	HR (95% CI)	P value	HR (95% CI)	P value
Age, y
60-69†	1.35 (1.16-1.59)	.0002		-
70-79†	1.64 (1.40-1.92)	<.0001	-	-
≥80†	2.08 (1.73-2.49)	<.0001	-	-
Age
10-year increment			1.17 (1.11-1.23)	<.0001
TTNT, mo
<3‡	1.45 (1.19-1.77)	.0003	1.58 (1.29-1.94)	<.0001
3-5.9‡	1.51 (1.23-1.85)	<.0001	1.34 (1.0-1.65)	.007
6-11.9‡	1.88 (1.53-2.41)	.23	1.69 (1.37-2.08)	<.0001
12-23.9‡	1.27 (1.00-1.61)	.20	1.22 (0.96-1.56)	.10
Treatment intent
Curative systemic§	0.56 (0.49-0.65)	<.0001	0.70 (0.59-0.83)	<.0001
Palliative systemic§	0.79 (0.66-0.93)	.005	0.71 (0.59-0.86)	.0003
LDH
200-399	1.14 (1.02-1.26)	.017	1.40 (1.18-1.66)	.0001
≥400	1.59 (1.48-1.7)	<.0001	2.52 (2.11-3.02)	<.0001
Unknown	1.06 (1.05-1.06)	<.0001	1.51 (1.25-1.82)	<.0001

	Unadjusted		Adjusted∗
	HR (95% CI)	P value	HR (95% CI)	P value
Age, y
60-69†	1.35 (1.16-1.59)	.0002		-
70-79†	1.64 (1.40-1.92)	<.0001	-	-
≥80†	2.08 (1.73-2.49)	<.0001	-	-
Age
10-year increment			1.17 (1.11-1.23)	<.0001
TTNT, mo
<3‡	1.45 (1.19-1.77)	.0003	1.58 (1.29-1.94)	<.0001
3-5.9‡	1.51 (1.23-1.85)	<.0001	1.34 (1.0-1.65)	.007
6-11.9‡	1.88 (1.53-2.41)	.23	1.69 (1.37-2.08)	<.0001
12-23.9‡	1.27 (1.00-1.61)	.20	1.22 (0.96-1.56)	.10
Treatment intent
Curative systemic§	0.56 (0.49-0.65)	<.0001	0.70 (0.59-0.83)	<.0001
Palliative systemic§	0.79 (0.66-0.93)	.005	0.71 (0.59-0.86)	.0003
LDH
200-399	1.14 (1.02-1.26)	.017	1.40 (1.18-1.66)	.0001
≥400	1.59 (1.48-1.7)	<.0001	2.52 (2.11-3.02)	<.0001
Unknown	1.06 (1.05-1.06)	<.0001	1.51 (1.25-1.82)	<.0001

Adjusted for sex, frailty, comorbidity burden as measured by aggregated disease groups, income quintile, and rurality.

Reference group, age 18-59 years.

Reference group, ≥24 months.

Reference group, palliative radiation.