Table 4

Multivariate analysis of the whole cohort assessing the impact of the combined variable CPI/PTCy on outcomes

OSPFSRINRM
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
CPI/PTCy (ref = no CPI, no PTCy)         
No prior CPI, PTCy 1.07 (0.87-1.31) .51478 0.86 (0.72-1.02) .0829 0.81(0.65-1) .0468 1 (0.75-1.35) .98425 
CPI, no PTCy 1.07 (0.8-1.43) .64562 0.86 (0.67-1.1) .2326 0.63(0.45-0.89) .00949 1.33 (0.91-1.92) .13792 
CPI + PTCy 1.05 (0.78-1.41) .75822 0.67 (0.51-0.86) .00225 0.46(0.31-0.67) <.0001 1.05 (0.72-1.54) .80268 
Age         
1 year increase 1.02(1.02-1.03) <.0001 1.01 (1.01-1.02) <.0001 1 (0.99-1.01) .64465 1.03(1.02-1.04) <.0001 
Year of HCT         
1 year increase 0.97 (0.95-1) .05768 0.96 (0.94-0.98) .00065 0.94(0.92-0.97) <.0001 1.01 (0.97-1.05) .76446 
Sex         
Female vs male 0.75(0.64-0.88) .00052 0.87 (0.76-1) .04552 0.92 (0.78-1.09) .33252 0.74(0.59-0.94) .01398 
Prior auto         
Yes vs no — — — — — — 0.88 (0.69-1.12) .29314 
Disease status (ref = CR)         
PR 1.49(1.23-1.8) <.0001 1.86 (1.58-2.18) <.0001 2.5(2.04-3.06) <.0001 1.11 (0.84-1.45) .46674 
Refractory 2.3(1.9-2.79) <.0001 2.54 (2.15-3) <.0001 3.26(2.64-4.03) <.0001 1.71(1.3-2.26) .00013 
Untreated/unknown 1.45 (0.97-2.18) .07346 1.89 (1.35-2.65) .00019 2.77(1.91-4.02) <.0001 0.66 (0.29-1.51) .3278 
Conditioning         
MAC vs RIC/NMA 1.04 (0.86-1.26) .68533 0.93 (0.78-1.1) .36664 0.9 (0.73-1.11) .31298 0.98 (0.73-1.31) .87128 
KPS         
<90 vs ≥90 1.45(1.22-1.71) <.0001 1.26 (1.09-1.46) .00214 1.19 (0.99-1.43) .06594 1.4(1.1-1.79) .00663 
HCT-CI (ref = 0)         
1-2 1.06 (0.83-1.35) .64702 1 (0.81-1.24) .9682 0.99 (0.76-1.3) .96913 0.95 (0.68-1.34) .7885 
≥3 1.16 (0.93-1.47) .19406 1.09 (0.9-1.33) .36856 1.05 (0.81-1.36) .71318 1.13 (0.83-1.54) .45164 
Missing 1.12 (0.92-1.36) .27659 1.18 (1-1.41) .05201 1.2 (0.98-1.47) .08481 1.16 (0.85-1.59) .33736 
 aGVHD 2-4 aGVHD 3-4 cGVHD Engraftment 
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value 
CPI/PTCy (ref = no CPI, no PTCy)         
No prior CPI, PTCy 1.1 (0.88-1.37) .39531 0.71 (0.48-1.06) .09204 0.63(0.51-0.77) <.0001 0.45(0.4-0.51) <.0001 
CPI, no PTCy 1.6(1.23-2.08) .00051 1.35 (0.89-2.04) .1635 1.09 (0.84-1.41) .50817 0.96 (0.82-1.13) .64993 
CPI + PTCy 1.33(1.02-1.73) .03427 1.2 (0.8-1.81) .38325 0.59(0.45-0.78) .00027 0.41(0.35-0.48) <.0001 
Age         
1 year increase 1.01 (1-1.01) .05034 1 (0.99-1.01) .63727 1.01 (1-1.01) .05988 1 (0.99-1) .13635 
Year of HCT         
1 year increase 1.04(1.01-1.07) .01404 1.05 (1-1.1) .06585 0.97(0.94-0.99) .0094 1.02 (1-1.03) .05127 
Sex         
Female vs male 0.96 (0.81-1.13) .61376 0.84 (0.63-1.11) .21073 0.84 (0.72-0.99) .03157 1.04 (0.94-1.14) .45748 
Prior auto         
Yes vs no 0.81 (0.68-0.97) .0217 0.68 (0.52-0.9) .00691 1.13 (0.94-1.35) .18448 — — 
Disease status (ref = CR)         
PR 1.02 (0.84-1.24) .80828 1.14 (0.83-1.57) .41176 1.12 (0.94-1.34) .19425 0.98 (0.88-1.1) .78679 
Refractory 1 (0.8-1.26) .99425 1.35 (0.95-1.92) .08989 1.17 (0.95-1.44) .1423 0.96 (0.84-1.09) .48279 
Untreated/unknown 1.41 (0.93-2.13) .10124 1.15 (0.53-2.49) .72098 0.76 (0.48-1.19) .23291 0.69 (0.53-0.9) .00574 
Conditioning         
MAC vs RIC/NMA 1.03 (0.83-1.27) .811 1.1 (0.79-1.52) .56611 1.08 (0.89-1.3) .42981 0.98 (0.87-1.1) .75075 
KPS         
<90 vs ≥90 0.94 (0.77-1.14) .52657 1.19 (0.88-1.62) .26355 1.04 (0.87-1.24) .67502 0.95 (0.85-1.06) .35279 
HCT-CI (ref = 0)         
1-2 1.25 (0.99-1.57) .05833 1.22 (0.85-1.76) .28314 1.09 (0.87-1.36) .45399 0.87 (0.76-1) .05671 
≥3 1.3(1.04-1.63) .02208 1.04 (0.72-1.51) .82206 1.16 (0.93-1.44) .1963 0.92 (0.81-1.06) .25398 
Missing 1.07 (0.84-1.36) .58689 0.87 (0.57-1.32) .50012 0.94 (0.76-1.16) .57773 0.84 (0.74-0.96) .00894 
OSPFSRINRM
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
CPI/PTCy (ref = no CPI, no PTCy)         
No prior CPI, PTCy 1.07 (0.87-1.31) .51478 0.86 (0.72-1.02) .0829 0.81(0.65-1) .0468 1 (0.75-1.35) .98425 
CPI, no PTCy 1.07 (0.8-1.43) .64562 0.86 (0.67-1.1) .2326 0.63(0.45-0.89) .00949 1.33 (0.91-1.92) .13792 
CPI + PTCy 1.05 (0.78-1.41) .75822 0.67 (0.51-0.86) .00225 0.46(0.31-0.67) <.0001 1.05 (0.72-1.54) .80268 
Age         
1 year increase 1.02(1.02-1.03) <.0001 1.01 (1.01-1.02) <.0001 1 (0.99-1.01) .64465 1.03(1.02-1.04) <.0001 
Year of HCT         
1 year increase 0.97 (0.95-1) .05768 0.96 (0.94-0.98) .00065 0.94(0.92-0.97) <.0001 1.01 (0.97-1.05) .76446 
Sex         
Female vs male 0.75(0.64-0.88) .00052 0.87 (0.76-1) .04552 0.92 (0.78-1.09) .33252 0.74(0.59-0.94) .01398 
Prior auto         
Yes vs no — — — — — — 0.88 (0.69-1.12) .29314 
Disease status (ref = CR)         
PR 1.49(1.23-1.8) <.0001 1.86 (1.58-2.18) <.0001 2.5(2.04-3.06) <.0001 1.11 (0.84-1.45) .46674 
Refractory 2.3(1.9-2.79) <.0001 2.54 (2.15-3) <.0001 3.26(2.64-4.03) <.0001 1.71(1.3-2.26) .00013 
Untreated/unknown 1.45 (0.97-2.18) .07346 1.89 (1.35-2.65) .00019 2.77(1.91-4.02) <.0001 0.66 (0.29-1.51) .3278 
Conditioning         
MAC vs RIC/NMA 1.04 (0.86-1.26) .68533 0.93 (0.78-1.1) .36664 0.9 (0.73-1.11) .31298 0.98 (0.73-1.31) .87128 
KPS         
<90 vs ≥90 1.45(1.22-1.71) <.0001 1.26 (1.09-1.46) .00214 1.19 (0.99-1.43) .06594 1.4(1.1-1.79) .00663 
HCT-CI (ref = 0)         
1-2 1.06 (0.83-1.35) .64702 1 (0.81-1.24) .9682 0.99 (0.76-1.3) .96913 0.95 (0.68-1.34) .7885 
≥3 1.16 (0.93-1.47) .19406 1.09 (0.9-1.33) .36856 1.05 (0.81-1.36) .71318 1.13 (0.83-1.54) .45164 
Missing 1.12 (0.92-1.36) .27659 1.18 (1-1.41) .05201 1.2 (0.98-1.47) .08481 1.16 (0.85-1.59) .33736 
 aGVHD 2-4 aGVHD 3-4 cGVHD Engraftment 
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value 
CPI/PTCy (ref = no CPI, no PTCy)         
No prior CPI, PTCy 1.1 (0.88-1.37) .39531 0.71 (0.48-1.06) .09204 0.63(0.51-0.77) <.0001 0.45(0.4-0.51) <.0001 
CPI, no PTCy 1.6(1.23-2.08) .00051 1.35 (0.89-2.04) .1635 1.09 (0.84-1.41) .50817 0.96 (0.82-1.13) .64993 
CPI + PTCy 1.33(1.02-1.73) .03427 1.2 (0.8-1.81) .38325 0.59(0.45-0.78) .00027 0.41(0.35-0.48) <.0001 
Age         
1 year increase 1.01 (1-1.01) .05034 1 (0.99-1.01) .63727 1.01 (1-1.01) .05988 1 (0.99-1) .13635 
Year of HCT         
1 year increase 1.04(1.01-1.07) .01404 1.05 (1-1.1) .06585 0.97(0.94-0.99) .0094 1.02 (1-1.03) .05127 
Sex         
Female vs male 0.96 (0.81-1.13) .61376 0.84 (0.63-1.11) .21073 0.84 (0.72-0.99) .03157 1.04 (0.94-1.14) .45748 
Prior auto         
Yes vs no 0.81 (0.68-0.97) .0217 0.68 (0.52-0.9) .00691 1.13 (0.94-1.35) .18448 — — 
Disease status (ref = CR)         
PR 1.02 (0.84-1.24) .80828 1.14 (0.83-1.57) .41176 1.12 (0.94-1.34) .19425 0.98 (0.88-1.1) .78679 
Refractory 1 (0.8-1.26) .99425 1.35 (0.95-1.92) .08989 1.17 (0.95-1.44) .1423 0.96 (0.84-1.09) .48279 
Untreated/unknown 1.41 (0.93-2.13) .10124 1.15 (0.53-2.49) .72098 0.76 (0.48-1.19) .23291 0.69 (0.53-0.9) .00574 
Conditioning         
MAC vs RIC/NMA 1.03 (0.83-1.27) .811 1.1 (0.79-1.52) .56611 1.08 (0.89-1.3) .42981 0.98 (0.87-1.1) .75075 
KPS         
<90 vs ≥90 0.94 (0.77-1.14) .52657 1.19 (0.88-1.62) .26355 1.04 (0.87-1.24) .67502 0.95 (0.85-1.06) .35279 
HCT-CI (ref = 0)         
1-2 1.25 (0.99-1.57) .05833 1.22 (0.85-1.76) .28314 1.09 (0.87-1.36) .45399 0.87 (0.76-1) .05671 
≥3 1.3(1.04-1.63) .02208 1.04 (0.72-1.51) .82206 1.16 (0.93-1.44) .1963 0.92 (0.81-1.06) .25398 
Missing 1.07 (0.84-1.36) .58689 0.87 (0.57-1.32) .50012 0.94 (0.76-1.16) .57773 0.84 (0.74-0.96) .00894 

Bold type highlights significant results.

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