Multivariate analysis of the whole cohort
| Variables . | OS∗ . | PFS . | RI† . | NRM† . | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| CPI | ||||||||
| CPI vs no | 1.03 (0.83-1.28) | .81079 | 0.81 (0.67-0.98) | .030486 | 0.58 (0.45-0.76) | <.0001 | 1.18 (0.89-1.56) | .247834 |
| Age | ||||||||
| 1 year increase | 1.02 (1.02-1.03) | <.0001 | 1.01 (1.01-1.02) | 1.00E-05 | 1 (0.99-1.01) | .643328 | 1.03(1.02-1.04) | <.0001 |
| Year of HCT | ||||||||
| 1 year increase | 0.97 (0.95-1) | .05901 | 0.96 (0.94-0.99) | .001894 | 0.95 (0.92-0.98) | .00019 | 1.01 (0.97-1.05) | .684549 |
| Sex | ||||||||
| Female vs male | 0.76 (0.64-0.89) | .00063 | 0.87 (0.76-0.99) | .039306 | 0.91 (0.77-1.07) | .243835 | 0.75(0.59-0.95) | .01789 |
| Donor (ref = HLA-id sib) | ||||||||
| Haploidentical donor | 1.15 (0.88-1.52) | .30552 | 0.85 (0.68-1.07) | .174514 | 0.63 (0.47-0.85) | .002299 | 1.58(1.08-2.32) | .018034 |
| HLA-MUD | 1.06 (0.87-1.27) | .57287 | 0.77 (0.66-0.9) | .001116 | 0.62 (0.51-0.76) | 2.00E-06 | 1.22 (0.92-1.62) | .162822 |
| Prior auto | ||||||||
| Yes vs no | ‡ | ‡ | ‡ | ‡ | ‡ | ‡ | 0.87 (0.68-1.11) | .265499 |
| Disease status (ref = CR) | ||||||||
| PR | 1.48 (1.22-1.8) | <.0001 | 1.85 (1.58-2.18) | <.0001 | 2.49 (2.03-3.05) | <.0001 | 1.09 (0.83-1.44) | .530116 |
| Refractory | 2.3 (1.9-2.79) | <.0001 | 2.52 (2.14-2.98) | <.0001 | 3.22 (2.61-3.98) | <.0001 | 1.7(1.29-2.23) | .000169 |
| Untreated/unknown | 1.46 (0.97-2.2) | .06697 | 1.87 (1.33-2.61) | .000265 | 2.67 (1.84-3.9) | <.0001 | 0.7 (0.31-1.59) | .395256 |
| Conditioning | ||||||||
| MAC vs RIC/NMA | 1.05 (0.86-1.27) | .65029 | 0.93 (0.78-1.1) | .39844 | 0.9 (0.73-1.1) | .299 | 0.99 (0.74-1.33) | .97051 |
| GVHD prevention (ref = post-Cy ± other[s]) | ||||||||
| CNI + MMF or MTX ± other(s) (except post-Cy) | 1.05 (0.8-1.37) | .73002 | 1.16 (0.93-1.45) | .192022 | 1.04 (0.78-1.39) | .791092 | 1.41 (0.99-2.02) | .059993 |
| KPS | ||||||||
| <90 vs ≥90 | 1.45 (1.23-1.72) | <.0001 | 1.26 (1.09-1.46) | .002262 | 1.18 (0.98-1.42) | .082424 | 1.41 (1.11-1.8) | .005481 |
| HCT-CI (ref = 0) | ||||||||
| 1-2 | 1.05 (0.83-1.34) | .66948 | 1.01 (0.82-1.24) | .955476 | 1 (0.77-1.31) | .974142 | 0.94 (0.66-1.32) | .702455 |
| ≥3 | 1.16 (0.92-1.46) | .20284 | 1.11 (0.91-1.35) | .308487 | 1.07 (0.83-1.39) | .597604 | 1.12 (0.82-1.53) | .468394 |
| Missing | 1.12 (0.92-1.37) | .26926 | 1.2 (1.01-1.42) | .040092 | 1.22 (0.99-1.5) | .059642 | 1.17 (0.86-1.6) | .328157 |
| Variables | aGVHD 2-4† | aGVHD 3-4† | cGVHD† | Engraftment† | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| CPI | ||||||||
| CPI vs no | 1.26 (1.04-1.53) | .018669 | 1.41(1.04-1.92) | .026118 | 1.02 (0.83-1.25) | .8564 | 0.94 (0.84-1.06) | .322565 |
| Age | ||||||||
| 1 year increase | 1.01(1-1.01) | .034587 | 1 (0.99-1.01) | .689297 | 1.01 (1-1.01) | .058425 | 1 (0.99-1) | .085297 |
| Year of HCT | ||||||||
| 1 year increase | 1.13(1.1-1.17) | <.0001 | 1.25(1.17-1.32) | <.0001 | 0.97 (0.94-0.99) | .012454 | 1.02(1-1.03) | .034822 |
| Sex | ||||||||
| Female vs male | 0.89 (0.76-1.06) | .18786 | 0.84 (0.63-1.11) | .211108 | 0.84 (0.72-0.98) | .027516 | 1.02 (0.93-1.12) | .688036 |
| Donor type (ref = HLA-id sib) | ||||||||
| Haploidentical donor | 1.73(1.31-2.29) | .000112 | 1.37 (0.9-2.1) | .144979 | 0.73 (0.57-0.94) | .014668 | 0.57(0.49-0.66) | <.0001 |
| HLA-MUD | 1.23 (0.99-1.53) | .060477 | 0.93 (0.66-1.32) | .689859 | 0.85 (0.71-1.02) | .078848 | 0.86(0.77-0.97) | .012339 |
| Prior auto | ||||||||
| Yes vs no | ‡ | ‡ | 0.74 (0.56-0.98) | .034986 | 1.12 (0.94-1.34) | .20785 | 1.04 (0.94-1.16) | .414808 |
| Disease status (ref = CR) | ||||||||
| PR | 1.19 (0.98-1.44) | .08271 | 1.36 (0.98-1.87) | .062665 | 1.13 (0.94-1.35) | .186424 | 0.99 (0.89-1.1) | .844664 |
| Refractory | 1.41(1.12-1.77) | .003122 | 1.98(1.39-2.81) | .000145 | 1.15 (0.93-1.41) | .198441 | 0.93 (0.82-1.05) | .247298 |
| Untreated/unknown | 1.31 (0.86-1.99) | .205037 | 1.1 (0.51-2.4) | .802956 | 0.71 (0.45-1.14) | .155757 | 0.66 (0.51-0.85) | .001694 |
| Conditioning | ||||||||
| MAC vs RIC/NMA | 1.22 (0.98-1.5) | .073515 | 1.33 (0.95-1.85) | .09499 | 1.06 (0.87-1.28) | .562134 | 0.94 (0.83-1.06) | .29401 |
| GVHD prevention (ref = post-Cy ± other[s]) | ||||||||
| CNI + MMF or MTX ± other(s) (except post-Cy) | 1.45(1.12-1.88) | .004689 | 1.74(1.16-2.6) | .006837 | 1.41 (1.1-1.79) | .005618 | 1.63(1.42-1.86) | <.0001 |
| KPS | ||||||||
| <90 vs ≥90 | 1.01 (0.83-1.24) | .886675 | 1.35 (0.99-1.85) | .060676 | 1.04 (0.87-1.25) | .632147 | 0.94 (0.84-1.06) | .312324 |
| HCT-CI (ref = 0) | ||||||||
| 1-2 | 1.11 (0.88-1.4) | .374883 | 1.01 (0.7-1.47) | .947637 | 1.1 (0.88-1.38) | .396141 | 0.9 (0.78-1.03) | .136238 |
| ≥3 | 1.16 (0.92-1.45) | .206787 | 0.92 (0.63-1.34) | .657795 | 1.17 (0.94-1.45) | .171626 | 0.92 (0.8-1.05) | .206807 |
| Missing | 1.37 (1.07-1.74) | .011833 | 1.2 (0.79-1.83) | .38974 | 0.94 (0.76-1.15) | .537813 | 0.81 (0.71-0.92) | .001424 |
| Variables . | OS∗ . | PFS . | RI† . | NRM† . | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| CPI | ||||||||
| CPI vs no | 1.03 (0.83-1.28) | .81079 | 0.81 (0.67-0.98) | .030486 | 0.58 (0.45-0.76) | <.0001 | 1.18 (0.89-1.56) | .247834 |
| Age | ||||||||
| 1 year increase | 1.02 (1.02-1.03) | <.0001 | 1.01 (1.01-1.02) | 1.00E-05 | 1 (0.99-1.01) | .643328 | 1.03(1.02-1.04) | <.0001 |
| Year of HCT | ||||||||
| 1 year increase | 0.97 (0.95-1) | .05901 | 0.96 (0.94-0.99) | .001894 | 0.95 (0.92-0.98) | .00019 | 1.01 (0.97-1.05) | .684549 |
| Sex | ||||||||
| Female vs male | 0.76 (0.64-0.89) | .00063 | 0.87 (0.76-0.99) | .039306 | 0.91 (0.77-1.07) | .243835 | 0.75(0.59-0.95) | .01789 |
| Donor (ref = HLA-id sib) | ||||||||
| Haploidentical donor | 1.15 (0.88-1.52) | .30552 | 0.85 (0.68-1.07) | .174514 | 0.63 (0.47-0.85) | .002299 | 1.58(1.08-2.32) | .018034 |
| HLA-MUD | 1.06 (0.87-1.27) | .57287 | 0.77 (0.66-0.9) | .001116 | 0.62 (0.51-0.76) | 2.00E-06 | 1.22 (0.92-1.62) | .162822 |
| Prior auto | ||||||||
| Yes vs no | ‡ | ‡ | ‡ | ‡ | ‡ | ‡ | 0.87 (0.68-1.11) | .265499 |
| Disease status (ref = CR) | ||||||||
| PR | 1.48 (1.22-1.8) | <.0001 | 1.85 (1.58-2.18) | <.0001 | 2.49 (2.03-3.05) | <.0001 | 1.09 (0.83-1.44) | .530116 |
| Refractory | 2.3 (1.9-2.79) | <.0001 | 2.52 (2.14-2.98) | <.0001 | 3.22 (2.61-3.98) | <.0001 | 1.7(1.29-2.23) | .000169 |
| Untreated/unknown | 1.46 (0.97-2.2) | .06697 | 1.87 (1.33-2.61) | .000265 | 2.67 (1.84-3.9) | <.0001 | 0.7 (0.31-1.59) | .395256 |
| Conditioning | ||||||||
| MAC vs RIC/NMA | 1.05 (0.86-1.27) | .65029 | 0.93 (0.78-1.1) | .39844 | 0.9 (0.73-1.1) | .299 | 0.99 (0.74-1.33) | .97051 |
| GVHD prevention (ref = post-Cy ± other[s]) | ||||||||
| CNI + MMF or MTX ± other(s) (except post-Cy) | 1.05 (0.8-1.37) | .73002 | 1.16 (0.93-1.45) | .192022 | 1.04 (0.78-1.39) | .791092 | 1.41 (0.99-2.02) | .059993 |
| KPS | ||||||||
| <90 vs ≥90 | 1.45 (1.23-1.72) | <.0001 | 1.26 (1.09-1.46) | .002262 | 1.18 (0.98-1.42) | .082424 | 1.41 (1.11-1.8) | .005481 |
| HCT-CI (ref = 0) | ||||||||
| 1-2 | 1.05 (0.83-1.34) | .66948 | 1.01 (0.82-1.24) | .955476 | 1 (0.77-1.31) | .974142 | 0.94 (0.66-1.32) | .702455 |
| ≥3 | 1.16 (0.92-1.46) | .20284 | 1.11 (0.91-1.35) | .308487 | 1.07 (0.83-1.39) | .597604 | 1.12 (0.82-1.53) | .468394 |
| Missing | 1.12 (0.92-1.37) | .26926 | 1.2 (1.01-1.42) | .040092 | 1.22 (0.99-1.5) | .059642 | 1.17 (0.86-1.6) | .328157 |
| Variables | aGVHD 2-4† | aGVHD 3-4† | cGVHD† | Engraftment† | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| CPI | ||||||||
| CPI vs no | 1.26 (1.04-1.53) | .018669 | 1.41(1.04-1.92) | .026118 | 1.02 (0.83-1.25) | .8564 | 0.94 (0.84-1.06) | .322565 |
| Age | ||||||||
| 1 year increase | 1.01(1-1.01) | .034587 | 1 (0.99-1.01) | .689297 | 1.01 (1-1.01) | .058425 | 1 (0.99-1) | .085297 |
| Year of HCT | ||||||||
| 1 year increase | 1.13(1.1-1.17) | <.0001 | 1.25(1.17-1.32) | <.0001 | 0.97 (0.94-0.99) | .012454 | 1.02(1-1.03) | .034822 |
| Sex | ||||||||
| Female vs male | 0.89 (0.76-1.06) | .18786 | 0.84 (0.63-1.11) | .211108 | 0.84 (0.72-0.98) | .027516 | 1.02 (0.93-1.12) | .688036 |
| Donor type (ref = HLA-id sib) | ||||||||
| Haploidentical donor | 1.73(1.31-2.29) | .000112 | 1.37 (0.9-2.1) | .144979 | 0.73 (0.57-0.94) | .014668 | 0.57(0.49-0.66) | <.0001 |
| HLA-MUD | 1.23 (0.99-1.53) | .060477 | 0.93 (0.66-1.32) | .689859 | 0.85 (0.71-1.02) | .078848 | 0.86(0.77-0.97) | .012339 |
| Prior auto | ||||||||
| Yes vs no | ‡ | ‡ | 0.74 (0.56-0.98) | .034986 | 1.12 (0.94-1.34) | .20785 | 1.04 (0.94-1.16) | .414808 |
| Disease status (ref = CR) | ||||||||
| PR | 1.19 (0.98-1.44) | .08271 | 1.36 (0.98-1.87) | .062665 | 1.13 (0.94-1.35) | .186424 | 0.99 (0.89-1.1) | .844664 |
| Refractory | 1.41(1.12-1.77) | .003122 | 1.98(1.39-2.81) | .000145 | 1.15 (0.93-1.41) | .198441 | 0.93 (0.82-1.05) | .247298 |
| Untreated/unknown | 1.31 (0.86-1.99) | .205037 | 1.1 (0.51-2.4) | .802956 | 0.71 (0.45-1.14) | .155757 | 0.66 (0.51-0.85) | .001694 |
| Conditioning | ||||||||
| MAC vs RIC/NMA | 1.22 (0.98-1.5) | .073515 | 1.33 (0.95-1.85) | .09499 | 1.06 (0.87-1.28) | .562134 | 0.94 (0.83-1.06) | .29401 |
| GVHD prevention (ref = post-Cy ± other[s]) | ||||||||
| CNI + MMF or MTX ± other(s) (except post-Cy) | 1.45(1.12-1.88) | .004689 | 1.74(1.16-2.6) | .006837 | 1.41 (1.1-1.79) | .005618 | 1.63(1.42-1.86) | <.0001 |
| KPS | ||||||||
| <90 vs ≥90 | 1.01 (0.83-1.24) | .886675 | 1.35 (0.99-1.85) | .060676 | 1.04 (0.87-1.25) | .632147 | 0.94 (0.84-1.06) | .312324 |
| HCT-CI (ref = 0) | ||||||||
| 1-2 | 1.11 (0.88-1.4) | .374883 | 1.01 (0.7-1.47) | .947637 | 1.1 (0.88-1.38) | .396141 | 0.9 (0.78-1.03) | .136238 |
| ≥3 | 1.16 (0.92-1.45) | .206787 | 0.92 (0.63-1.34) | .657795 | 1.17 (0.94-1.45) | .171626 | 0.92 (0.8-1.05) | .206807 |
| Missing | 1.37 (1.07-1.74) | .011833 | 1.2 (0.79-1.83) | .38974 | 0.94 (0.76-1.15) | .537813 | 0.81 (0.71-0.92) | .001424 |
Bold type highlights significant results.
CNI, calcineurin inhibitor; MMF, mycophenolate mofetil; MTX, methotrexate; ref, reference.
No significant interaction of covariates and CPI use.
Cox-model (cause-specific Cox) including all important covariates for adjustment.
Stratified on variable because of nonproportionality.