Univariate and multivariate Cox proportional hazards models
| Variable before BsAb . | Category . | PFS . | OS . | ||
|---|---|---|---|---|---|
| HR (univariate) . | HR (multivariate) . | HR (univariate) . | HR (multivariate) . | ||
| Age at initiation BsAb | Continuous variable | P = .986 | — | P = .637 | — |
| Gender | Male/female | 1.08 (0.65-1.82; P = .764) | — | 1.19 (0.66-2.15; P = .564) | — |
| IPI score at BsAb | Continuous variable | P = .158 | P = .593 | P = .011 | P = .028 |
| Treatment lines before BsAb | Continuous variable | P = .400 | — | P = .399 | — |
| Time point of CAR-T failure | Late vs int vs early | 1.86 (1.30-2.64; P < .001) | 1.73 (1.18-2.54; P = .005) | 2.43 (1.55-3.81; P < .001) | 2.31 (1.40-3.82; P = .001) |
| Best response last therapy | CR/PR vs SD/PD | 2.16 (1.28-3.67; P = .004) | 1.92 (1.09-3.38; P = .024) | 3.17 (1.63-6.15; P < .001) | 2.74 (1.35-5.55; P = .005) |
| Therapy between CAR-Ts and BsAb | BsAb as first salvage vs BsAb as later salvage | 1.79 (1.09-2.94; P = .022) | 2.33 (1.36-3.98; P = .002) | 1.68 (0.95-2.97; P = .075) | 2.41 (1.28-4.54; P = .006) |
| LDH value at BsAb (U/L) | Continuous variable | P = .024 | P = .065 | P < .001 | P = .018 |
| Extranodal lesions | No vs yes | 1.26 (0.77-2.08; P = .358) | — | 1.24 (0.69-2.22; P = .471) | — |
| Bulky dz (>7.5 cm) | No vs yes | 1.64 (0.97-2.78; P = .066) | — | 2.26 (1.24-4.10; P = .008) | — |
| Variable before BsAb . | Category . | PFS . | OS . | ||
|---|---|---|---|---|---|
| HR (univariate) . | HR (multivariate) . | HR (univariate) . | HR (multivariate) . | ||
| Age at initiation BsAb | Continuous variable | P = .986 | — | P = .637 | — |
| Gender | Male/female | 1.08 (0.65-1.82; P = .764) | — | 1.19 (0.66-2.15; P = .564) | — |
| IPI score at BsAb | Continuous variable | P = .158 | P = .593 | P = .011 | P = .028 |
| Treatment lines before BsAb | Continuous variable | P = .400 | — | P = .399 | — |
| Time point of CAR-T failure | Late vs int vs early | 1.86 (1.30-2.64; P < .001) | 1.73 (1.18-2.54; P = .005) | 2.43 (1.55-3.81; P < .001) | 2.31 (1.40-3.82; P = .001) |
| Best response last therapy | CR/PR vs SD/PD | 2.16 (1.28-3.67; P = .004) | 1.92 (1.09-3.38; P = .024) | 3.17 (1.63-6.15; P < .001) | 2.74 (1.35-5.55; P = .005) |
| Therapy between CAR-Ts and BsAb | BsAb as first salvage vs BsAb as later salvage | 1.79 (1.09-2.94; P = .022) | 2.33 (1.36-3.98; P = .002) | 1.68 (0.95-2.97; P = .075) | 2.41 (1.28-4.54; P = .006) |
| LDH value at BsAb (U/L) | Continuous variable | P = .024 | P = .065 | P < .001 | P = .018 |
| Extranodal lesions | No vs yes | 1.26 (0.77-2.08; P = .358) | — | 1.24 (0.69-2.22; P = .471) | — |
| Bulky dz (>7.5 cm) | No vs yes | 1.64 (0.97-2.78; P = .066) | — | 2.26 (1.24-4.10; P = .008) | — |