Most frequent AEs and severe AEs
| Event . | Any grade, n (%) . | Grade ≥ 3, n (%) . |
|---|---|---|
| Constipation | 10 (48) | — |
| Thrombocytopenia | 10 (48) | 9 (43) |
| Abdominal distension | 9 (43) | — |
| Diarrhea | 7 (33) | 1 (5) |
| Nausea | 7 (33) | — |
| Abdominal pain | 6 (29) | — |
| Gastroesophageal reflux disease | 5 (24) | — |
| Anemia | 4 (19) | 3 (14) |
| Pyrexia | 4 (19) | 1 (5) |
| Febrile neutropenia | 3 (14) | 3 (14) |
| Hemorrhoids | 3 (14) | — |
| Blood phosphorus decreased | 2 (10) | — |
| Decreased appetite | 2 (10) | — |
| Deep vein thrombosis | 2 (10) | — |
| Dizziness | 2 (10) | — |
| Dry eye | 2 (10) | — |
| Dyspepsia | 2 (10) | — |
| Hypercholesterolemia | 2 (10) | — |
| Hypertriglyceridemia | 2 (10) | — |
| Hypokalemia | 2 (10) | — |
| Mucosal inflammation | 2 (10) | — |
| Rash | 2 (10) | — |
| Event . | Any grade, n (%) . | Grade ≥ 3, n (%) . |
|---|---|---|
| Constipation | 10 (48) | — |
| Thrombocytopenia | 10 (48) | 9 (43) |
| Abdominal distension | 9 (43) | — |
| Diarrhea | 7 (33) | 1 (5) |
| Nausea | 7 (33) | — |
| Abdominal pain | 6 (29) | — |
| Gastroesophageal reflux disease | 5 (24) | — |
| Anemia | 4 (19) | 3 (14) |
| Pyrexia | 4 (19) | 1 (5) |
| Febrile neutropenia | 3 (14) | 3 (14) |
| Hemorrhoids | 3 (14) | — |
| Blood phosphorus decreased | 2 (10) | — |
| Decreased appetite | 2 (10) | — |
| Deep vein thrombosis | 2 (10) | — |
| Dizziness | 2 (10) | — |
| Dry eye | 2 (10) | — |
| Dyspepsia | 2 (10) | — |
| Hypercholesterolemia | 2 (10) | — |
| Hypertriglyceridemia | 2 (10) | — |
| Hypokalemia | 2 (10) | — |
| Mucosal inflammation | 2 (10) | — |
| Rash | 2 (10) | — |
Data are n (%) per patient. Shown are the AEs occurring in ≥2 patients. AEs are classified by frequency and then by alphabetical order.