Adverse events in 5% or more of patients
| n (%) . | 50 mg qod (n = 6) . | 50 mg (n = 3) . | 100 mg (n = 4) . | 150 mg (n = 4) . | 200 mg (n = 4) . | 250 mg (n = 4) . | 300 mg (n = 16) . | Total (N = 41) . |
|---|---|---|---|---|---|---|---|---|
| Nausea | 0 | 0 | 2 (50.0) | 3 (75.0) | 2 (50.0) | 2 (50.0) | 5 (31.3) | 14 (34.1) |
| Febrile neutropenia | 0 | 1 (33.3) | 2 (50.0) | 2 (50.0) | 0 | 1 (25.0) | 7 (43.8) | 13 (31.7) |
| Diarrhea | 1 (16.7) | 0 | 1 (25.0) | 1 (25.0) | 1 (25.0) | 1 (25.0) | 4 (25.0) | 9 (22.0) |
| Dyspnea | 2 (33.3) | 0 | 1 (25.0) | 1 (25.0) | 0 | 1 (25.0) | 4 (25.0) | 9 (22.0) |
| Hypokalemia | 0 | 0 | 2 (50.0) | 1 (25.0) | 2 (50.0) | 1 (25.0) | 3 (18.8) | 9 (22.0) |
| Platelet count decreased | 0 | 1 (33.3) | 1 (25.0) | 3 (75.0) | 1 (25.0) | 1 (25.0) | 2 (12.5) | 9 (22.0) |
| Anemia | 0 | 0 | 2 (50.0) | 2 (50.0) | 1 (25.0) | 1 (25.0) | 1 (6.3) | 7 (17.1) |
| Vomiting | 0 | 0 | 1 (25.0) | 0 | 0 | 2 (50.0) | 4 (25.0) | 7 (17.1) |
| Cough | 2 (33.3) | 0 | 1 (25.0) | 1 (25.0) | 1 (25.0) | 0 | 1 (6.3) | 6 (14.6) |
| Fatigue | 0 | 0 | 0 | 3 (75.0) | 1 (25.0) | 0 | 2 (12.5) | 6 (14.6) |
| Stomatitis | 2 (33.3) | 0 | 1 (25.0) | 1 (25.0) | 0 | 0 | 2 (12.5) | 6 (14.6) |
| Arthralgia | 0 | 0 | 2 (50.0) | 0 | 0 | 0 | 2 (12.5) | 4 (9.8) |
| Dizziness | 1 (16.7) | 0 | 0 | 1 (25.0) | 0 | 0 | 2 (12.5) | 4 (9.8) |
| Hypotension | 1 (16.7) | 0 | 1 (25.0) | 1 (25.0) | 0 | 0 | 1 (6.3) | 4 (9.8) |
| Anxiety | 1 (16.7) | 0 | 2 (50.0) | 0 | 0 | 0 | 0 | 3 (7.3) |
| Contusion | 2 (33.3) | 0 | 0 | 0 | 0 | 0 | 1 (6.3) | 3 (7.3) |
| COVID-19 | 1 (16.7) | 0 | 0 | 1 (25.0) | 1 (25.0) | 0 | 0 | 3 (7.3) |
| Fall | 1 (16.7) | 0 | 0 | 0 | 0 | 0 | 2 (12.5) | 3 (7.3) |
| Gingival bleeding | 0 | 0 | 0 | 1 (25.0) | 0 | 1 (25.0) | 1 (6.3) | 3 (7.3) |
| Hemorrhoids | 0 | 0 | 0 | 1 (25.0) | 1 (25.0) | 0 | 1 (6.3) | 3 (7.3) |
| Lung infection | 0 | 0 | 0 | 0 | 0 | 0 | 3 (18.8) | 3 (7.3) |
| Neutrophil count decreased | 0 | 0 | 1 (25.0) | 0 | 0 | 0 | 2 (12.5) | 3 (7.3) |
| Oropharyngeal pain | 1 (16.7) | 0 | 1 (25.0) | 0 | 0 | 0 | 1 (6.3) | 3 (7.3) |
| White blood cell count decreased | 0 | 0 | 0 | 0 | 1 (25.0) | 0 | 2 (12.5) | 3 (7.3) |
| n (%) . | 50 mg qod (n = 6) . | 50 mg (n = 3) . | 100 mg (n = 4) . | 150 mg (n = 4) . | 200 mg (n = 4) . | 250 mg (n = 4) . | 300 mg (n = 16) . | Total (N = 41) . |
|---|---|---|---|---|---|---|---|---|
| Nausea | 0 | 0 | 2 (50.0) | 3 (75.0) | 2 (50.0) | 2 (50.0) | 5 (31.3) | 14 (34.1) |
| Febrile neutropenia | 0 | 1 (33.3) | 2 (50.0) | 2 (50.0) | 0 | 1 (25.0) | 7 (43.8) | 13 (31.7) |
| Diarrhea | 1 (16.7) | 0 | 1 (25.0) | 1 (25.0) | 1 (25.0) | 1 (25.0) | 4 (25.0) | 9 (22.0) |
| Dyspnea | 2 (33.3) | 0 | 1 (25.0) | 1 (25.0) | 0 | 1 (25.0) | 4 (25.0) | 9 (22.0) |
| Hypokalemia | 0 | 0 | 2 (50.0) | 1 (25.0) | 2 (50.0) | 1 (25.0) | 3 (18.8) | 9 (22.0) |
| Platelet count decreased | 0 | 1 (33.3) | 1 (25.0) | 3 (75.0) | 1 (25.0) | 1 (25.0) | 2 (12.5) | 9 (22.0) |
| Anemia | 0 | 0 | 2 (50.0) | 2 (50.0) | 1 (25.0) | 1 (25.0) | 1 (6.3) | 7 (17.1) |
| Vomiting | 0 | 0 | 1 (25.0) | 0 | 0 | 2 (50.0) | 4 (25.0) | 7 (17.1) |
| Cough | 2 (33.3) | 0 | 1 (25.0) | 1 (25.0) | 1 (25.0) | 0 | 1 (6.3) | 6 (14.6) |
| Fatigue | 0 | 0 | 0 | 3 (75.0) | 1 (25.0) | 0 | 2 (12.5) | 6 (14.6) |
| Stomatitis | 2 (33.3) | 0 | 1 (25.0) | 1 (25.0) | 0 | 0 | 2 (12.5) | 6 (14.6) |
| Arthralgia | 0 | 0 | 2 (50.0) | 0 | 0 | 0 | 2 (12.5) | 4 (9.8) |
| Dizziness | 1 (16.7) | 0 | 0 | 1 (25.0) | 0 | 0 | 2 (12.5) | 4 (9.8) |
| Hypotension | 1 (16.7) | 0 | 1 (25.0) | 1 (25.0) | 0 | 0 | 1 (6.3) | 4 (9.8) |
| Anxiety | 1 (16.7) | 0 | 2 (50.0) | 0 | 0 | 0 | 0 | 3 (7.3) |
| Contusion | 2 (33.3) | 0 | 0 | 0 | 0 | 0 | 1 (6.3) | 3 (7.3) |
| COVID-19 | 1 (16.7) | 0 | 0 | 1 (25.0) | 1 (25.0) | 0 | 0 | 3 (7.3) |
| Fall | 1 (16.7) | 0 | 0 | 0 | 0 | 0 | 2 (12.5) | 3 (7.3) |
| Gingival bleeding | 0 | 0 | 0 | 1 (25.0) | 0 | 1 (25.0) | 1 (6.3) | 3 (7.3) |
| Hemorrhoids | 0 | 0 | 0 | 1 (25.0) | 1 (25.0) | 0 | 1 (6.3) | 3 (7.3) |
| Lung infection | 0 | 0 | 0 | 0 | 0 | 0 | 3 (18.8) | 3 (7.3) |
| Neutrophil count decreased | 0 | 0 | 1 (25.0) | 0 | 0 | 0 | 2 (12.5) | 3 (7.3) |
| Oropharyngeal pain | 1 (16.7) | 0 | 1 (25.0) | 0 | 0 | 0 | 1 (6.3) | 3 (7.3) |
| White blood cell count decreased | 0 | 0 | 0 | 0 | 1 (25.0) | 0 | 2 (12.5) | 3 (7.3) |