Multivariable analysis by donor group in the PTCy cohort
| End points . | MSD vs MUD . | P (Raw) . | P∗ (Bonferroni) . | MSD vs haplo . | P (Raw) . | P∗ (Bonferroni) . | MSD vs MMUD HR/OR (95% CI) . | P (Raw) . | P∗ (Bonferroni) . |
|---|---|---|---|---|---|---|---|---|---|
| HR/OR (95% CI) . | HR/OR (95% CI) . | ||||||||
| OS† | 1.20 (1.03-1.41) | .019 | .096 | 1.02 (0.88-1.18) | .781 | 1 | 1.00 (0.83-1.21) | .979 | 1 |
| DFS† | 1.21 (1.05-1.40) | .01 | .048 | 1.04 (0.90-1.19) | .61 | 1 | 1.07 (0.90-1.28) | .446 | 1 |
| NRM† | 1.00 (0.77-1.30) | .986 | 1 | 0.68 (0.53-0.88) | .003 | .014 | 0.74 (0.54-1.01) | .055 | .164 |
| Relapse† | 1.29 (1.08-1.53) | .004 | .02 | 1.30 (1.10-1.54) | .003 | .015 | 1.26 (1.01-1.56) | .038 | .153 |
| Grade 2-4 aGVHD‡ | 0.92 (0.73-1.16) | .49 | 1 | 0.88 (0.70-1.11) | .281 | 1 | 1.02 (0.76-1.35) | .917 | 1 |
| Grade 3-4 aGVHD‡ | 1.55 (1.06-2.27) | .024 | .141 | 1.30 (0.90-1.87) | .16 | .638 | 1.46 (0.90-2.37) | .123 | .615 |
| Chronic GVHD† | 1.09 (0.89-1.32) | .408 | 1 | 0.92 (0.76-1.11) | .375 | 1 | 0.85 (0.68-1.08) | .178 | .712 |
| End points . | MSD vs MUD . | P (Raw) . | P∗ (Bonferroni) . | MSD vs haplo . | P (Raw) . | P∗ (Bonferroni) . | MSD vs MMUD HR/OR (95% CI) . | P (Raw) . | P∗ (Bonferroni) . |
|---|---|---|---|---|---|---|---|---|---|
| HR/OR (95% CI) . | HR/OR (95% CI) . | ||||||||
| OS† | 1.20 (1.03-1.41) | .019 | .096 | 1.02 (0.88-1.18) | .781 | 1 | 1.00 (0.83-1.21) | .979 | 1 |
| DFS† | 1.21 (1.05-1.40) | .01 | .048 | 1.04 (0.90-1.19) | .61 | 1 | 1.07 (0.90-1.28) | .446 | 1 |
| NRM† | 1.00 (0.77-1.30) | .986 | 1 | 0.68 (0.53-0.88) | .003 | .014 | 0.74 (0.54-1.01) | .055 | .164 |
| Relapse† | 1.29 (1.08-1.53) | .004 | .02 | 1.30 (1.10-1.54) | .003 | .015 | 1.26 (1.01-1.56) | .038 | .153 |
| Grade 2-4 aGVHD‡ | 0.92 (0.73-1.16) | .49 | 1 | 0.88 (0.70-1.11) | .281 | 1 | 1.02 (0.76-1.35) | .917 | 1 |
| Grade 3-4 aGVHD‡ | 1.55 (1.06-2.27) | .024 | .141 | 1.30 (0.90-1.87) | .16 | .638 | 1.46 (0.90-2.37) | .123 | .615 |
| Chronic GVHD† | 1.09 (0.89-1.32) | .408 | 1 | 0.92 (0.76-1.11) | .375 | 1 | 0.85 (0.68-1.08) | .178 | .712 |
aGVHD, acute GVHD; haplo, young, haploidentical donor; MMUD, young, mismatched unrelated donor; MSD, older-aged, matched sibling donor; MUD, young, matched unrelated donor; OR, odds ratio.
Stepdown Bonferroni P value is reported to adjust for multiple comparisons in the PTCy cohort; 95% CI values are not adjusted for multiple comparisons.
HR reported for OS, DFS, NRM, relapse, and chronic GVHD.
OR reported for grade 2 to 4, and grade 3 to 4 acute GVHD.