Cox regression analysis of factors associated with OS in the training cohort
| . | HR (95% CI) . | (Overall) P . |
|---|---|---|
| Conditioning intensity | ||
| MAC | 1.00 | |
| RIC | 1.08 (0.97-1.20) | .17 |
| Donor type | ||
| MRD/MUD | 1.00 | |
| HD/MMUD | 1.34 (1.19-1.51) | <.0001 |
| Age at allo-HCT, y | ||
| <49 | 1.00 | |
| 50-59 | 1.36 (1.17-1.58) | <.0001 |
| ≥60 | 1.67 (1.44-1.94) | <.0001 |
| Sex | ||
| Male | 1.00 | |
| Female | 0.89 (0.80-0.99) | .04 |
| KPS at allo-HCT | ||
| 90-100 | 1.00 | |
| <90 | 1.33 (1.19-1.48) | <.0001 |
| HCT-CI | ||
| 0-2 | 1.00 | |
| ≥3 | 1.36 (1.19-1.55) | <.0001 |
| CMV donor/patient | ||
| +/− | 1.16 (1.03-1.32) | .01 |
| Other | 1.00 | |
| Sex match donor/patient | ||
| Female to male | 1.15 (1.00-1.31) | .04 |
| Other | 1.00 | |
| Genotype | ||
| CALR+/MPL+ | 1.00 | |
| JAK2+/triple negative | 1.56 (1.26-1.92) | <.0001 |
| . | HR (95% CI) . | (Overall) P . |
|---|---|---|
| Conditioning intensity | ||
| MAC | 1.00 | |
| RIC | 1.08 (0.97-1.20) | .17 |
| Donor type | ||
| MRD/MUD | 1.00 | |
| HD/MMUD | 1.34 (1.19-1.51) | <.0001 |
| Age at allo-HCT, y | ||
| <49 | 1.00 | |
| 50-59 | 1.36 (1.17-1.58) | <.0001 |
| ≥60 | 1.67 (1.44-1.94) | <.0001 |
| Sex | ||
| Male | 1.00 | |
| Female | 0.89 (0.80-0.99) | .04 |
| KPS at allo-HCT | ||
| 90-100 | 1.00 | |
| <90 | 1.33 (1.19-1.48) | <.0001 |
| HCT-CI | ||
| 0-2 | 1.00 | |
| ≥3 | 1.36 (1.19-1.55) | <.0001 |
| CMV donor/patient | ||
| +/− | 1.16 (1.03-1.32) | .01 |
| Other | 1.00 | |
| Sex match donor/patient | ||
| Female to male | 1.15 (1.00-1.31) | .04 |
| Other | 1.00 | |
| Genotype | ||
| CALR+/MPL+ | 1.00 | |
| JAK2+/triple negative | 1.56 (1.26-1.92) | <.0001 |
Overall P values were obtained using the Wald test. A total of 3559 patients and 1607 events were included in the model.
HD, haploidentical donor; MAC, myeloablative conditioning; MMUD, mismatched unrelated donor; MRD, matched related donor; MUD, matched unrelated donor; RIC, reduced intensity conditioning.