ITP treatments administered in hospital for critical bleeds in patients with ITP
| ITP treatment . | Patients, n (%) . | Arrival in ER to first administration, median (IQR), h . | First dose, median (IQR) . |
|---|---|---|---|
| Adults (n = 15) | |||
| Platelet transfusion | 11 (73.3) | 5 (4-8) | 1 (1-1) units |
| Corticosteroids | 10 (66.7) | 19 (10-34) | — |
| Prednisone | 7 (46.7) | 28 (19-38) | 60 (50-80) mg |
| Methylprednisolone | 5 (33.3) | 14.5 (5-56) | 1 (0.1-1) g |
| Dexamethasone | 4 (26.7) | 15 (10-26.5) | 7 (4-25) mg |
| IV immunoglobulin | 8 (53.3) | 8 (7-50) | 70 (60-80) g |
| TPO-RAs | 1 (6.7) | 51 (31-71) | — |
| Eltrombopag | 1 (6.7) | 31 (31-31) | 75 (75-75) mg |
| Romiplostim | 1 (6.7) | 71 (71-71) | 100 (100-100) μg |
| Danazol | 1 (6.7) | 107 (107-107) | 200 (200-200) mg |
| Rh immunoglobulin | 1 (6.7) | 46 (20-72) | 300 (300-300) μg |
| Children (n = 13) | |||
| IV immunoglobulin | 10 (76.9) | 7 (4-9) | 42.5 (24-65) g |
| Corticosteroids | 8 (61.5) | 19.5 (4-51.5) | — |
| Methylprednisolone | 8 (61.5) | 5 (2-25) | 0.85 (0.061-92.5) g |
| Prednisone | 4 (30.8) | 53 (21-88.5) | 75 (45-80) mg |
| Dexamethasone | 1 (7.7) | 53 (53-53) | 4 (4-4) mg |
| Platelet transfusion | 8 (61.5) | 4 (2-21) | 1 (1-1) units |
| TPO-RAs | 4 (30.8) | 22 (21-23) | — |
| Romiplostim | 3 (23.1) | 22 (12-27) | 170 (155-250) μg |
| Eltrombopag | 2 (15.4) | 22 (21-23) | 50 (25-75) mg |
| Antifibrinolytics | 4 (30.8) | 35.5 (8-65) | — |
| IV aminocaproic acid | 2 (15.4) | 26.5 (0-53) | Not available |
| Oral aminocaproic acid | 2 (15.4) | 46.5 (18-75) | 3001 (2-6000) mg |
| IV tranexamic acid | 1 (7.7) | Not available | 400 (400-400) mg |
| Oral tranexamic acid | 2 (15.4) | 36.5 (8-65) | 1000 (1000-1000) mg |
| Rituximab | 1 (7.7) | 22 (22-22) | 258 (258-258) mg |
| Urgent splenectomy | 1 (7.7) | Not applicable | Not applicable |
| ITP treatment . | Patients, n (%) . | Arrival in ER to first administration, median (IQR), h . | First dose, median (IQR) . |
|---|---|---|---|
| Adults (n = 15) | |||
| Platelet transfusion | 11 (73.3) | 5 (4-8) | 1 (1-1) units |
| Corticosteroids | 10 (66.7) | 19 (10-34) | — |
| Prednisone | 7 (46.7) | 28 (19-38) | 60 (50-80) mg |
| Methylprednisolone | 5 (33.3) | 14.5 (5-56) | 1 (0.1-1) g |
| Dexamethasone | 4 (26.7) | 15 (10-26.5) | 7 (4-25) mg |
| IV immunoglobulin | 8 (53.3) | 8 (7-50) | 70 (60-80) g |
| TPO-RAs | 1 (6.7) | 51 (31-71) | — |
| Eltrombopag | 1 (6.7) | 31 (31-31) | 75 (75-75) mg |
| Romiplostim | 1 (6.7) | 71 (71-71) | 100 (100-100) μg |
| Danazol | 1 (6.7) | 107 (107-107) | 200 (200-200) mg |
| Rh immunoglobulin | 1 (6.7) | 46 (20-72) | 300 (300-300) μg |
| Children (n = 13) | |||
| IV immunoglobulin | 10 (76.9) | 7 (4-9) | 42.5 (24-65) g |
| Corticosteroids | 8 (61.5) | 19.5 (4-51.5) | — |
| Methylprednisolone | 8 (61.5) | 5 (2-25) | 0.85 (0.061-92.5) g |
| Prednisone | 4 (30.8) | 53 (21-88.5) | 75 (45-80) mg |
| Dexamethasone | 1 (7.7) | 53 (53-53) | 4 (4-4) mg |
| Platelet transfusion | 8 (61.5) | 4 (2-21) | 1 (1-1) units |
| TPO-RAs | 4 (30.8) | 22 (21-23) | — |
| Romiplostim | 3 (23.1) | 22 (12-27) | 170 (155-250) μg |
| Eltrombopag | 2 (15.4) | 22 (21-23) | 50 (25-75) mg |
| Antifibrinolytics | 4 (30.8) | 35.5 (8-65) | — |
| IV aminocaproic acid | 2 (15.4) | 26.5 (0-53) | Not available |
| Oral aminocaproic acid | 2 (15.4) | 46.5 (18-75) | 3001 (2-6000) mg |
| IV tranexamic acid | 1 (7.7) | Not available | 400 (400-400) mg |
| Oral tranexamic acid | 2 (15.4) | 36.5 (8-65) | 1000 (1000-1000) mg |
| Rituximab | 1 (7.7) | 22 (22-22) | 258 (258-258) mg |
| Urgent splenectomy | 1 (7.7) | Not applicable | Not applicable |