Univariate and multivariate Cox proportional hazards regression on PFS
| Factor . | Univariable . | P value . | Multivariable . | P value . |
|---|---|---|---|---|
| HR (95% CI) . | HR (95% CI) . | |||
| iDS 4/5 | 3.26 (1.72-6.18) | <.001 | 2.82 (1.47-5.42) | .002 |
| FLIPI-2 3/5 | 2.47 (1.36-4.50) | .003 | 2.79 (1.52-5.12) | .001 |
| Age >60, y | 2.89 (1.55-5.37) | .001 | ||
| Sex, male | 1.39 (0.76-2.53) | .281 | ||
| Hemoglobin <12 mg/dL | 2.63 (1.39-4.98) | .003 | ||
| BM biopsy, positive | 1.30 (0.69-2.43) | .413 | ||
| LoDLIN >6 cm | 1.32 (0.71-2.44) | .385 | ||
| B2M > ULN | 1.19 (0.65-2.16) | .574 | ||
| RB | 0.96 (0.52-1.74) | .882 | ||
| Experimental arm | 2.33 (1.24-4.42) | .009 | 2.15 (1.11-4.14) | .022 |
| Factor . | Univariable . | P value . | Multivariable . | P value . |
|---|---|---|---|---|
| HR (95% CI) . | HR (95% CI) . | |||
| iDS 4/5 | 3.26 (1.72-6.18) | <.001 | 2.82 (1.47-5.42) | .002 |
| FLIPI-2 3/5 | 2.47 (1.36-4.50) | .003 | 2.79 (1.52-5.12) | .001 |
| Age >60, y | 2.89 (1.55-5.37) | .001 | ||
| Sex, male | 1.39 (0.76-2.53) | .281 | ||
| Hemoglobin <12 mg/dL | 2.63 (1.39-4.98) | .003 | ||
| BM biopsy, positive | 1.30 (0.69-2.43) | .413 | ||
| LoDLIN >6 cm | 1.32 (0.71-2.44) | .385 | ||
| B2M > ULN | 1.19 (0.65-2.16) | .574 | ||
| RB | 0.96 (0.52-1.74) | .882 | ||
| Experimental arm | 2.33 (1.24-4.42) | .009 | 2.15 (1.11-4.14) | .022 |