Table 1.

Intramolecular interactions in FXII

FN2 - CDFN2 - KNGKNG - Act loopAct loop - CD
H35 → G357 R36L266 T227 → S349 R343 → Q482 
H35 → V359 R36E225 D251K346 R345 → E551 
R36E502 Q33 → S224 D253K346 R353G531 
R36V359 L38 → D264 R265 → E411 R353 → Q504 
K45 → Q501 H40 → D264 W268 → R362  
 D61 → R229 W257 => K346  
  W268 => K346  
FN2 - CDFN2 - KNGKNG - Act loopAct loop - CD
H35 → G357 R36L266 T227 → S349 R343 → Q482 
H35 → V359 R36E225 D251K346 R345 → E551 
R36E502 Q33 → S224 D253K346 R353G531 
R36V359 L38 → D264 R265 → E411 R353 → Q504 
K45 → Q501 H40 → D264 W268 → R362  
 D61 → R229 W257 => K346  
  W268 => K346  

Act loop, activation loop.

Interactions involving hydrogen bonds (→) or cationic p-bonds (=>). Underlined amino acids are highly conserved among vertebrate species.