Intramolecular interactions in FXII
| FN2 - CD . | FN2 - KNG . | KNG - Act loop . | Act loop - CD . |
|---|---|---|---|
| H35 → G357 | R36 → L266 | T227 → S349 | R343 → Q482 |
| H35 → V359 | R36 → E225 | D251 → K346 | R345 → E551 |
| R36 → E502 | Q33 → S224 | D253 → K346 | R353 → G531 |
| R36 → V359 | L38 → D264 | R265 → E411 | R353 → Q504 |
| K45 → Q501 | H40 → D264 | W268 → R362 | |
| D61 → R229 | W257 => K346 | ||
| W268 => K346 |
| FN2 - CD . | FN2 - KNG . | KNG - Act loop . | Act loop - CD . |
|---|---|---|---|
| H35 → G357 | R36 → L266 | T227 → S349 | R343 → Q482 |
| H35 → V359 | R36 → E225 | D251 → K346 | R345 → E551 |
| R36 → E502 | Q33 → S224 | D253 → K346 | R353 → G531 |
| R36 → V359 | L38 → D264 | R265 → E411 | R353 → Q504 |
| K45 → Q501 | H40 → D264 | W268 → R362 | |
| D61 → R229 | W257 => K346 | ||
| W268 => K346 |
Act loop, activation loop.
Interactions involving hydrogen bonds (→) or cationic p-bonds (=>). Underlined amino acids are highly conserved among vertebrate species.