Table 1.

Demographic and laboratory features among participants of the COVAC-TP trial by SARS-CoV-2 clinical phenotype

Study variable, statistic/unitOverall, N = 38COVID-19, n = 18MIS-C, n = 20P value
Age, y, mean (SD) 11.7 (4.5) 14 (3.9) 9.6 (4.1) <.01 
Sex assigned at birth, n (%)     
Female 18 (47.4) 11 (61.1) 7 (35.0) .1 
Male 20 (52.6) 7 (38.9) 13 (65.0)  
Race/ethnicity, n (%)     
Non-Hispanic White 8 (21.1) 2 (11.1) 6 (30.0) .6 
Non-Hispanic Black 12 (31.6) 5 (27.8) 7 (35.0)  
Hispanic 12 (31.6) 7 (38.9) 5 (25.0)  
Other or mixed race 3 (7.9) 2 (11.1) 1 (5.0)  
Unknown 3 (7.9) 2 (11.1) 1 (5.0)  
BMI, median (IQR) 22.7 (17.2-31.8) 32.1 (23.1-43.4) 20.1 (16.2-23.3) <.01 
Complete blood count, median (IQR)     
Hemoglobin, g/dL 11.4 (9.6-12.8) 12.8 (11.9-13.4) 9.8 (9.1-11.2) <.01 
White blood cell count, × 103/μL 6.4 (5.1-11.2) 5.9 (3.6-10.3) 9.2 (5.2-13.8) .1 
Platelet count, × 103/μL 153 (115-217) 181 (125-253) 145 (109-176) .3 
Coagulation data at screening, median (IQR)     
Prothrombin time, s 13.9 (12.7-15.2) 13.4 (12.6-14.0) 14.4 (13-16) .08 
Partial thromboplastin time, s 33.5 (31.6-40) 32.1 (30-34) 39 (33-43.5) .01 
International normalized ratio 1.1 (1-1.3) 1.0 (0.9-1.2) 1.2 (1.1-1.3) .04 
Fibrinogen, mg/dL 503 (374-573) 487 (388-525) 530 (367-580) .8 
Serum creatinine, mg/dL 0.6 (0.5-0.7) 0.6 (0.5-0.7) 0.6 (0.5-0.7) .4 
D-dimer, μg/mL 2.2 (1-4.7) 1.0 (0.7-2.2) 3.4 (2.1-7.1) <.01 
Study variable, statistic/unitOverall, N = 38COVID-19, n = 18MIS-C, n = 20P value
Age, y, mean (SD) 11.7 (4.5) 14 (3.9) 9.6 (4.1) <.01 
Sex assigned at birth, n (%)     
Female 18 (47.4) 11 (61.1) 7 (35.0) .1 
Male 20 (52.6) 7 (38.9) 13 (65.0)  
Race/ethnicity, n (%)     
Non-Hispanic White 8 (21.1) 2 (11.1) 6 (30.0) .6 
Non-Hispanic Black 12 (31.6) 5 (27.8) 7 (35.0)  
Hispanic 12 (31.6) 7 (38.9) 5 (25.0)  
Other or mixed race 3 (7.9) 2 (11.1) 1 (5.0)  
Unknown 3 (7.9) 2 (11.1) 1 (5.0)  
BMI, median (IQR) 22.7 (17.2-31.8) 32.1 (23.1-43.4) 20.1 (16.2-23.3) <.01 
Complete blood count, median (IQR)     
Hemoglobin, g/dL 11.4 (9.6-12.8) 12.8 (11.9-13.4) 9.8 (9.1-11.2) <.01 
White blood cell count, × 103/μL 6.4 (5.1-11.2) 5.9 (3.6-10.3) 9.2 (5.2-13.8) .1 
Platelet count, × 103/μL 153 (115-217) 181 (125-253) 145 (109-176) .3 
Coagulation data at screening, median (IQR)     
Prothrombin time, s 13.9 (12.7-15.2) 13.4 (12.6-14.0) 14.4 (13-16) .08 
Partial thromboplastin time, s 33.5 (31.6-40) 32.1 (30-34) 39 (33-43.5) .01 
International normalized ratio 1.1 (1-1.3) 1.0 (0.9-1.2) 1.2 (1.1-1.3) .04 
Fibrinogen, mg/dL 503 (374-573) 487 (388-525) 530 (367-580) .8 
Serum creatinine, mg/dL 0.6 (0.5-0.7) 0.6 (0.5-0.7) 0.6 (0.5-0.7) .4 
D-dimer, μg/mL 2.2 (1-4.7) 1.0 (0.7-2.2) 3.4 (2.1-7.1) <.01 

BMI, body mass index; SD, standard deviation.

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