Demographic and laboratory features among participants of the COVAC-TP trial by SARS-CoV-2 clinical phenotype
| Study variable, statistic/unit . | Overall, N = 38 . | COVID-19, n = 18 . | MIS-C, n = 20 . | P value . |
|---|---|---|---|---|
| Age, y, mean (SD) | 11.7 (4.5) | 14 (3.9) | 9.6 (4.1) | <.01 |
| Sex assigned at birth, n (%) | ||||
| Female | 18 (47.4) | 11 (61.1) | 7 (35.0) | .1 |
| Male | 20 (52.6) | 7 (38.9) | 13 (65.0) | |
| Race/ethnicity, n (%) | ||||
| Non-Hispanic White | 8 (21.1) | 2 (11.1) | 6 (30.0) | .6 |
| Non-Hispanic Black | 12 (31.6) | 5 (27.8) | 7 (35.0) | |
| Hispanic | 12 (31.6) | 7 (38.9) | 5 (25.0) | |
| Other or mixed race | 3 (7.9) | 2 (11.1) | 1 (5.0) | |
| Unknown | 3 (7.9) | 2 (11.1) | 1 (5.0) | |
| BMI, median (IQR) | 22.7 (17.2-31.8) | 32.1 (23.1-43.4) | 20.1 (16.2-23.3) | <.01 |
| Complete blood count, median (IQR) | ||||
| Hemoglobin, g/dL | 11.4 (9.6-12.8) | 12.8 (11.9-13.4) | 9.8 (9.1-11.2) | <.01 |
| White blood cell count, × 103/μL | 6.4 (5.1-11.2) | 5.9 (3.6-10.3) | 9.2 (5.2-13.8) | .1 |
| Platelet count, × 103/μL | 153 (115-217) | 181 (125-253) | 145 (109-176) | .3 |
| Coagulation data at screening, median (IQR) | ||||
| Prothrombin time, s | 13.9 (12.7-15.2) | 13.4 (12.6-14.0) | 14.4 (13-16) | .08 |
| Partial thromboplastin time, s | 33.5 (31.6-40) | 32.1 (30-34) | 39 (33-43.5) | .01 |
| International normalized ratio | 1.1 (1-1.3) | 1.0 (0.9-1.2) | 1.2 (1.1-1.3) | .04 |
| Fibrinogen, mg/dL | 503 (374-573) | 487 (388-525) | 530 (367-580) | .8 |
| Serum creatinine, mg/dL | 0.6 (0.5-0.7) | 0.6 (0.5-0.7) | 0.6 (0.5-0.7) | .4 |
| D-dimer, μg/mL | 2.2 (1-4.7) | 1.0 (0.7-2.2) | 3.4 (2.1-7.1) | <.01 |
| Study variable, statistic/unit . | Overall, N = 38 . | COVID-19, n = 18 . | MIS-C, n = 20 . | P value . |
|---|---|---|---|---|
| Age, y, mean (SD) | 11.7 (4.5) | 14 (3.9) | 9.6 (4.1) | <.01 |
| Sex assigned at birth, n (%) | ||||
| Female | 18 (47.4) | 11 (61.1) | 7 (35.0) | .1 |
| Male | 20 (52.6) | 7 (38.9) | 13 (65.0) | |
| Race/ethnicity, n (%) | ||||
| Non-Hispanic White | 8 (21.1) | 2 (11.1) | 6 (30.0) | .6 |
| Non-Hispanic Black | 12 (31.6) | 5 (27.8) | 7 (35.0) | |
| Hispanic | 12 (31.6) | 7 (38.9) | 5 (25.0) | |
| Other or mixed race | 3 (7.9) | 2 (11.1) | 1 (5.0) | |
| Unknown | 3 (7.9) | 2 (11.1) | 1 (5.0) | |
| BMI, median (IQR) | 22.7 (17.2-31.8) | 32.1 (23.1-43.4) | 20.1 (16.2-23.3) | <.01 |
| Complete blood count, median (IQR) | ||||
| Hemoglobin, g/dL | 11.4 (9.6-12.8) | 12.8 (11.9-13.4) | 9.8 (9.1-11.2) | <.01 |
| White blood cell count, × 103/μL | 6.4 (5.1-11.2) | 5.9 (3.6-10.3) | 9.2 (5.2-13.8) | .1 |
| Platelet count, × 103/μL | 153 (115-217) | 181 (125-253) | 145 (109-176) | .3 |
| Coagulation data at screening, median (IQR) | ||||
| Prothrombin time, s | 13.9 (12.7-15.2) | 13.4 (12.6-14.0) | 14.4 (13-16) | .08 |
| Partial thromboplastin time, s | 33.5 (31.6-40) | 32.1 (30-34) | 39 (33-43.5) | .01 |
| International normalized ratio | 1.1 (1-1.3) | 1.0 (0.9-1.2) | 1.2 (1.1-1.3) | .04 |
| Fibrinogen, mg/dL | 503 (374-573) | 487 (388-525) | 530 (367-580) | .8 |
| Serum creatinine, mg/dL | 0.6 (0.5-0.7) | 0.6 (0.5-0.7) | 0.6 (0.5-0.7) | .4 |
| D-dimer, μg/mL | 2.2 (1-4.7) | 1.0 (0.7-2.2) | 3.4 (2.1-7.1) | <.01 |
BMI, body mass index; SD, standard deviation.