Selected differential gene dependencies in AML
| Gene symbol . | Differential gene dependency∗ . | P value . | q value . |
|---|---|---|---|
| MYB | –1.04 | 3.8E-76 | 6.4E-84 |
| SDHB | –0.39 | 1.1E-08 | 8.7E-07 |
| DHODH | –0.36 | 1.9E-11 | 7.2E-10 |
| OGDH | –0.33 | 3.3E-06 | 2.1E-04 |
| DLD | –0.29 | 8.8E-08 | 3.1E-06 |
| BCL2 | –0.27 | 1.3E-13 | 3.0E-12 |
| DLST | –0.27 | 1.7E-08 | 5.5E-07 |
| SDHC | –0.25 | 2.1E-05 | 6.9E-04 |
| SDHD | –0.24 | 1.2E-06 | 2.9E-05 |
| SDHA | –0.24 | 2.0E-07 | 6.3E-06 |
| PDXK | –0.12 | 3.9E-07 | 7.3E-06 |
| Gene symbol . | Differential gene dependency∗ . | P value . | q value . |
|---|---|---|---|
| MYB | –1.04 | 3.8E-76 | 6.4E-84 |
| SDHB | –0.39 | 1.1E-08 | 8.7E-07 |
| DHODH | –0.36 | 1.9E-11 | 7.2E-10 |
| OGDH | –0.33 | 3.3E-06 | 2.1E-04 |
| DLD | –0.29 | 8.8E-08 | 3.1E-06 |
| BCL2 | –0.27 | 1.3E-13 | 3.0E-12 |
| DLST | –0.27 | 1.7E-08 | 5.5E-07 |
| SDHC | –0.25 | 2.1E-05 | 6.9E-04 |
| SDHD | –0.24 | 1.2E-06 | 2.9E-05 |
| SDHA | –0.24 | 2.0E-07 | 6.3E-06 |
| PDXK | –0.12 | 3.9E-07 | 7.3E-06 |
Members of the αKG dehydrogenase complex are shown in bold.
Difference in AML vs other cancers of normalized depletion of sgRNAs targeting individual genes across available CRISPR screens.