Baseline characteristics in nonfrail vs frail patients with MM
| . | Nonfrail (n = 315), median (IQR) or n (%) . | Frail (n = 200), median (IQR) or n (%) . | P value . |
|---|---|---|---|
| Age, y (n = 515) | 64 (57-71) | 70 (63-78) | <.001 |
| Female (n = 515) | 128 (41) | 79 (40) | .85 |
| ECOG PS ≥2 (n = 243) | 25 (17) | 42 (45) | <.001 |
| Hb <10 mg/dL (n = 493) | 76 (25) | 80 (41) | <.001 |
| Ca >11 mg/dL (n = 487) | 14 (5) | 11 (6) | .67 |
| Cr >2 mg/dL (n = 491) | 36 (12) | 31 (16) | .22 |
| ISS III (n = 479) | 80 (27) | 88 (48) | <.001 |
| High-risk FISH abnormalities (n = 437) | 108 (39) | 80 (49) | .046 |
| R-ISS III (n = 446) | 34 (13) | 32 (19) | .07 |
| Diagnosis after 2013 (n = 515) | 140 (44) | 83 (42) | .52 |
| First-line induction (n = 475) | |||
| PI based | 88 (30) | 56 (31) | |
| IMiD based | 130 (44) | 70 (39) | |
| PI + IMiD based | 63 (21) | 41 (23) | |
| Other | 13 (4) | 14 (8) | |
| Early transplantation (n = 515) | 133 (42) | 55 (28) | <.001 |
| ≥PR to first-line induction (n = 406) | 222 (85) | 124 (86) | 1.00 |
| ≥VGPR to first-line induction (n = 406) | 146 (56) | 72 (50) | .25 |
| Married/relationship (n = 515) | 273 (87) | 148 (74) | <.001 |
| . | Nonfrail (n = 315), median (IQR) or n (%) . | Frail (n = 200), median (IQR) or n (%) . | P value . |
|---|---|---|---|
| Age, y (n = 515) | 64 (57-71) | 70 (63-78) | <.001 |
| Female (n = 515) | 128 (41) | 79 (40) | .85 |
| ECOG PS ≥2 (n = 243) | 25 (17) | 42 (45) | <.001 |
| Hb <10 mg/dL (n = 493) | 76 (25) | 80 (41) | <.001 |
| Ca >11 mg/dL (n = 487) | 14 (5) | 11 (6) | .67 |
| Cr >2 mg/dL (n = 491) | 36 (12) | 31 (16) | .22 |
| ISS III (n = 479) | 80 (27) | 88 (48) | <.001 |
| High-risk FISH abnormalities (n = 437) | 108 (39) | 80 (49) | .046 |
| R-ISS III (n = 446) | 34 (13) | 32 (19) | .07 |
| Diagnosis after 2013 (n = 515) | 140 (44) | 83 (42) | .52 |
| First-line induction (n = 475) | |||
| PI based | 88 (30) | 56 (31) | |
| IMiD based | 130 (44) | 70 (39) | |
| PI + IMiD based | 63 (21) | 41 (23) | |
| Other | 13 (4) | 14 (8) | |
| Early transplantation (n = 515) | 133 (42) | 55 (28) | <.001 |
| ≥PR to first-line induction (n = 406) | 222 (85) | 124 (86) | 1.00 |
| ≥VGPR to first-line induction (n = 406) | 146 (56) | 72 (50) | .25 |
| Married/relationship (n = 515) | 273 (87) | 148 (74) | <.001 |
Ca, calcium; Cr, creatinine; ECOG, Eastern Cooperative Oncology Group; Hb, hemoglobin; IMiD, immunomodulatory drug; IQR, interquartile range.