Infections in BCMA-directed CAR T-cell recipients
| . | Idecabtagene vicleucel (n = 28) . | Ciltacabtagene autoleucel (n = 29) . | Overall (n = 57) . |
|---|---|---|---|
| Grade of infection | |||
| Outpatient | 10 (35.7%) | 8 (27.6%) | 18 (31.6%) |
| Inpatient | 11 (39.3%) | 8 (27.6%) | 19 (33.3%) |
| ICU | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Death | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| Type of infection | |||
| Bacterial | 10 (39.3%) | 9 (31.0%) | 19 (35.1%) |
| Viral | 17 (60.7%) | 19 (65.5%) | 36 (63.2%) |
| Fungal | 2 (7.1%) | 1 (3.4%) | 3 (5.3%) |
| Pathogens: bacterial | |||
| Escherichia coli | 1 (3.6%) | 4 (13.8%) | 5 (8.8%) |
| Enterobacter cloacae | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Enterococcus spp. | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Haemophilus influenzae | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Klebsiella pneumoniae | 2 (7.1%) | 0 (0%) | 2 (3.5%) |
| Proteus mirabilis | 1 (3.6%) | 1 (3.4%) | 2 (3.5%) |
| Pseudomonas aeruginosa | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Ruminococcus gnavus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Staphylococcus epidermidis | 2 (7.1%) | 1 (3.4%) | 3 (5.3%) |
| Staphylococcus hominis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Streptococcus pneumoniae | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Pathogens: viral | |||
| Adenovirus | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| CMV | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| HSV | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Influenza A | 3 (10.7%) | 1 (3.4%) | 4 (7.0%) |
| Norovirus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Parainfluenza | 3 (10.7%) | 2 (6.9%) | 5 (8.8%) |
| Rhinovirus | 2 (7.1%) | 3 (10.3%) | 5 (8.8%) |
| RSV | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Sapovirus | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| SARS-CoV-2 | 5 (17.9%) | 5 (17.2%) | 10 (17.5%) |
| Pathogens: fungal | |||
| Aspergillus spp. | 1 (3.6%) | 0 (0%) | 2 (3.5%) |
| Candida albicans | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Type of pathogen | |||
| Gram-negative bacteria | 6 (21.4%) | 6 (20.7%) | 12 (19.3%) |
| Gram-positive bacteria | 5 (17.9%) | 2 (6.9%) | 7 (12.3%) |
| Respiratory virus | 14 (50.0%) | 14 (48.3%) | 28 (49.1%) |
| Herpesviridae | 2 (7.1%) | 3 (10.3%) | 5 (8.8%) |
| Other viruses | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Mold fungus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Yeast fungus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Unidentified pathogen | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Type of infection | |||
| Bloodstream infection | 3 (10.7%) | 4 (13.8%) | 7 (12.3%) |
| Diverticulitis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Enteritis | 1 (3.6%) | 1 (3.4%) | 2 (3.5%) |
| Otitis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Virus reactivation | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| Respiratory tract infection | 15 (53.6%) | 15 (51.7%) | 30 (52.6%) |
| Oral thrush | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Stomatitis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Urinary tract infection | 4 (14.3%) | 1 (3.4%) | 5 (8.8%) |
| Disseminated infection | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Time from infusion to first infection, d | |||
| Mean (SD) | 50.4 (55.0) | 58.1 (55.4) | 54.3 (54.9) |
| Median (min, max) | 33.5 (1.00, 200) | 40.0 (0, 190) | 38.5 (0, 200) |
| Timing of first infection | |||
| Early (up to 30 d) | 15 (53.6%) | 13 (44.8%) | 28 (49.1%) |
| Late (after 30 d) | 15 (53.6%) | 17 (58.6%) | 32 (56.1%) |
| Duration of first infection | |||
| Mean (SD) | 14.1 (16.6) | 13.3 (12.0) | 13.7 (14.4) |
| Median (min, max) | 9.50 (3.00, 92.0) | 10.0 (0, 60.0) | 10.0 (0, 92.0) |
| Neutropenia during first infection | |||
| No | 13 (46.4%) | 17 (58.6%) | 30 (52.6%) |
| Yes | 17 (60.7%) | 8 (27.6%) | 25 (43.9%) |
| Aplasia | 0 (0%) | 5 (17.2%) | 5 (8.8%) |
| Hospitalization because of infection | |||
| Hospitalization | 8 (28.6%) | 8 (27.6%) | 16 (28.1%) |
| ICU | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| >1 infection episode | |||
| Yes | 3 (10.7%) | 4 (13.8%) | 7 (12.3%) |
| . | Idecabtagene vicleucel (n = 28) . | Ciltacabtagene autoleucel (n = 29) . | Overall (n = 57) . |
|---|---|---|---|
| Grade of infection | |||
| Outpatient | 10 (35.7%) | 8 (27.6%) | 18 (31.6%) |
| Inpatient | 11 (39.3%) | 8 (27.6%) | 19 (33.3%) |
| ICU | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Death | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| Type of infection | |||
| Bacterial | 10 (39.3%) | 9 (31.0%) | 19 (35.1%) |
| Viral | 17 (60.7%) | 19 (65.5%) | 36 (63.2%) |
| Fungal | 2 (7.1%) | 1 (3.4%) | 3 (5.3%) |
| Pathogens: bacterial | |||
| Escherichia coli | 1 (3.6%) | 4 (13.8%) | 5 (8.8%) |
| Enterobacter cloacae | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Enterococcus spp. | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Haemophilus influenzae | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Klebsiella pneumoniae | 2 (7.1%) | 0 (0%) | 2 (3.5%) |
| Proteus mirabilis | 1 (3.6%) | 1 (3.4%) | 2 (3.5%) |
| Pseudomonas aeruginosa | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Ruminococcus gnavus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Staphylococcus epidermidis | 2 (7.1%) | 1 (3.4%) | 3 (5.3%) |
| Staphylococcus hominis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Streptococcus pneumoniae | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Pathogens: viral | |||
| Adenovirus | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| CMV | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| HSV | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Influenza A | 3 (10.7%) | 1 (3.4%) | 4 (7.0%) |
| Norovirus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Parainfluenza | 3 (10.7%) | 2 (6.9%) | 5 (8.8%) |
| Rhinovirus | 2 (7.1%) | 3 (10.3%) | 5 (8.8%) |
| RSV | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Sapovirus | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| SARS-CoV-2 | 5 (17.9%) | 5 (17.2%) | 10 (17.5%) |
| Pathogens: fungal | |||
| Aspergillus spp. | 1 (3.6%) | 0 (0%) | 2 (3.5%) |
| Candida albicans | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Type of pathogen | |||
| Gram-negative bacteria | 6 (21.4%) | 6 (20.7%) | 12 (19.3%) |
| Gram-positive bacteria | 5 (17.9%) | 2 (6.9%) | 7 (12.3%) |
| Respiratory virus | 14 (50.0%) | 14 (48.3%) | 28 (49.1%) |
| Herpesviridae | 2 (7.1%) | 3 (10.3%) | 5 (8.8%) |
| Other viruses | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Mold fungus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Yeast fungus | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Unidentified pathogen | 1 (3.6%) | 2 (6.9%) | 3 (5.3%) |
| Type of infection | |||
| Bloodstream infection | 3 (10.7%) | 4 (13.8%) | 7 (12.3%) |
| Diverticulitis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Enteritis | 1 (3.6%) | 1 (3.4%) | 2 (3.5%) |
| Otitis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Virus reactivation | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| Respiratory tract infection | 15 (53.6%) | 15 (51.7%) | 30 (52.6%) |
| Oral thrush | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Stomatitis | 1 (3.6%) | 0 (0%) | 1 (1.8%) |
| Urinary tract infection | 4 (14.3%) | 1 (3.4%) | 5 (8.8%) |
| Disseminated infection | 0 (0%) | 1 (3.4%) | 1 (1.8%) |
| Time from infusion to first infection, d | |||
| Mean (SD) | 50.4 (55.0) | 58.1 (55.4) | 54.3 (54.9) |
| Median (min, max) | 33.5 (1.00, 200) | 40.0 (0, 190) | 38.5 (0, 200) |
| Timing of first infection | |||
| Early (up to 30 d) | 15 (53.6%) | 13 (44.8%) | 28 (49.1%) |
| Late (after 30 d) | 15 (53.6%) | 17 (58.6%) | 32 (56.1%) |
| Duration of first infection | |||
| Mean (SD) | 14.1 (16.6) | 13.3 (12.0) | 13.7 (14.4) |
| Median (min, max) | 9.50 (3.00, 92.0) | 10.0 (0, 60.0) | 10.0 (0, 92.0) |
| Neutropenia during first infection | |||
| No | 13 (46.4%) | 17 (58.6%) | 30 (52.6%) |
| Yes | 17 (60.7%) | 8 (27.6%) | 25 (43.9%) |
| Aplasia | 0 (0%) | 5 (17.2%) | 5 (8.8%) |
| Hospitalization because of infection | |||
| Hospitalization | 8 (28.6%) | 8 (27.6%) | 16 (28.1%) |
| ICU | 1 (3.6%) | 3 (10.3%) | 4 (7.0%) |
| >1 infection episode | |||
| Yes | 3 (10.7%) | 4 (13.8%) | 7 (12.3%) |
CMV, cytomegalovirus; HSV, herpes simplex virus; ICU, intensive care unit; max, maximum; min, minimum; RSV, respiratory syncytial virus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SD, standard deviation.