Associations with moderate or severe depression at enrollment
| Variable . | Category . | OR . | 95% CI . | P value . |
|---|---|---|---|---|
| Sex | Male | Ref | ||
| Female | 0.77 | 0.36-1.66 | .51 | |
| Age at histiocytosis diagnosis | Continuous, y | 1.00 | 0.97-1.02 | .71 |
| Age at enrollment | Continuous, y | 0.99 | 0.96-1.02 | .41 |
| Diagnosis | Non-ECD | Ref | ||
| ECD or mixed ECD | 4.15 | 1.21-14.21 | .02 | |
| Neurologic involvement | No | Ref | ||
| Yes | 2.58 | 1.06-6.27 | .04 | |
| Driver mutation | None or other | Ref | ||
| BRAFV600E | 0.87 | 0.39-1.92 | .73 | |
| RAS isoform only | 0.75 | 0.15-3.69 | .72 | |
| MAP2K1 only | 0.27 | 0.03-2.19 | .22 | |
| Length of undiagnosed illness | Continuous, y | 1.15 | 1.04-1.26 | .004 |
| Length of diagnosed illness | Continuous, y | 1.02 | 0.97-1.08 | .43 |
| Treatment at enrollment | None | Ref | ||
| Conventional | 3.96 | 1.11-14.13 | .03 | |
| Targeted | 1.92 | 0.80-4.63 | .15 | |
| Best response at enrollment | PR/CR | Ref | ||
| SD/PD | 1.67 | 0.26-10.82 | .59 | |
| Education | High school or some high school | Ref | ||
| Undergraduate | 0.77 | 0.26-2.25 | .63 | |
| Graduate or postgraduate | 0.85 | 0.32-2.26 | .75 | |
| Employment at enrollment | Full-time | Ref | ||
| Part-time | 2.72 | 0.57-12.99 | .21 | |
| Unemployed | 13.38 | 4.11-43.56 | <.0001 | |
| Retired | 4.45 | 1.30-15.26 | .02 | |
| Financial burden scale | Continuous | 1.22 | 1.02-1.44 | .03 |
| Financial worry scale | Continuous | 1.84 | 1.36-2.48 | <.0001 |
| FACT-Cog: perceived cognitive impairments scale | Continuous | 0.94 | 0.92-0.97 | <.0001 |
| FACT-Cog: perceived cognitive impairments on qol scale | Continuous | 0.74 | 0.67-0.81 | <.0001 |
| FACT-Cog: comments from others scale | Continuous | 0.75 | 0.66-0.84 | <.0001 |
| FACT-Cog: perceived cognitive abilities scale | Continuous | 0.91 | 0.87-0.96 | .0002 |
| FACT-G: physical well-being scale | Continuous | 0.83 | 0.77-0.89 | <.0001 |
| FACT-G: emotional well-being scale | Continuous | 0.76 | 0.68-0.84 | <.0001 |
| FACT-G: social well-being scale | Continuous | 0.83 | 0.78-0.89 | <.0001 |
| FACT-G: functional well-being scale | Continuous | 0.73 | 0.66-0.81 | <.0001 |
| FACT-G: total | Continuous | 0.88 | 0.85-0.92 | <.0001 |
| BFI: total | Continuous | 1.66 | 1.38-1.99 | <.0001 |
| BPI: total | Continuous | 1.25 | 1.09-1.44 | .001 |
| ECD-SS: neurologic symptom | No | Ref | ||
| Yes | Not | Estimable∗ | ||
| ECD-SS: gastrological symptom | No | Ref | ||
| Yes | 6.56 | 1.93-22.34 | .003 | |
| ECD-SS: pain symptom | No | Ref | ||
| Yes | 1.60 | 0.72-3.57 | .25 | |
| ECD-SS: vision symptom | No | Ref | ||
| Yes | 4.35 | 1.99-9.50 | .0002 | |
| ECD-SS: respiratory symptom | No | Ref | ||
| Yes | 2.66 | 1.24-5.72 | .01 | |
| Top 3 ECD-SS symptoms: severity | Continuous | 1.81 | 1.38-2.37 | <.0001 |
| Top 5 ECD-SS symptoms: severity | Continuous | 1.85 | 1.41-2.43 | <.0001 |
| Variable . | Category . | OR . | 95% CI . | P value . |
|---|---|---|---|---|
| Sex | Male | Ref | ||
| Female | 0.77 | 0.36-1.66 | .51 | |
| Age at histiocytosis diagnosis | Continuous, y | 1.00 | 0.97-1.02 | .71 |
| Age at enrollment | Continuous, y | 0.99 | 0.96-1.02 | .41 |
| Diagnosis | Non-ECD | Ref | ||
| ECD or mixed ECD | 4.15 | 1.21-14.21 | .02 | |
| Neurologic involvement | No | Ref | ||
| Yes | 2.58 | 1.06-6.27 | .04 | |
| Driver mutation | None or other | Ref | ||
| BRAFV600E | 0.87 | 0.39-1.92 | .73 | |
| RAS isoform only | 0.75 | 0.15-3.69 | .72 | |
| MAP2K1 only | 0.27 | 0.03-2.19 | .22 | |
| Length of undiagnosed illness | Continuous, y | 1.15 | 1.04-1.26 | .004 |
| Length of diagnosed illness | Continuous, y | 1.02 | 0.97-1.08 | .43 |
| Treatment at enrollment | None | Ref | ||
| Conventional | 3.96 | 1.11-14.13 | .03 | |
| Targeted | 1.92 | 0.80-4.63 | .15 | |
| Best response at enrollment | PR/CR | Ref | ||
| SD/PD | 1.67 | 0.26-10.82 | .59 | |
| Education | High school or some high school | Ref | ||
| Undergraduate | 0.77 | 0.26-2.25 | .63 | |
| Graduate or postgraduate | 0.85 | 0.32-2.26 | .75 | |
| Employment at enrollment | Full-time | Ref | ||
| Part-time | 2.72 | 0.57-12.99 | .21 | |
| Unemployed | 13.38 | 4.11-43.56 | <.0001 | |
| Retired | 4.45 | 1.30-15.26 | .02 | |
| Financial burden scale | Continuous | 1.22 | 1.02-1.44 | .03 |
| Financial worry scale | Continuous | 1.84 | 1.36-2.48 | <.0001 |
| FACT-Cog: perceived cognitive impairments scale | Continuous | 0.94 | 0.92-0.97 | <.0001 |
| FACT-Cog: perceived cognitive impairments on qol scale | Continuous | 0.74 | 0.67-0.81 | <.0001 |
| FACT-Cog: comments from others scale | Continuous | 0.75 | 0.66-0.84 | <.0001 |
| FACT-Cog: perceived cognitive abilities scale | Continuous | 0.91 | 0.87-0.96 | .0002 |
| FACT-G: physical well-being scale | Continuous | 0.83 | 0.77-0.89 | <.0001 |
| FACT-G: emotional well-being scale | Continuous | 0.76 | 0.68-0.84 | <.0001 |
| FACT-G: social well-being scale | Continuous | 0.83 | 0.78-0.89 | <.0001 |
| FACT-G: functional well-being scale | Continuous | 0.73 | 0.66-0.81 | <.0001 |
| FACT-G: total | Continuous | 0.88 | 0.85-0.92 | <.0001 |
| BFI: total | Continuous | 1.66 | 1.38-1.99 | <.0001 |
| BPI: total | Continuous | 1.25 | 1.09-1.44 | .001 |
| ECD-SS: neurologic symptom | No | Ref | ||
| Yes | Not | Estimable∗ | ||
| ECD-SS: gastrological symptom | No | Ref | ||
| Yes | 6.56 | 1.93-22.34 | .003 | |
| ECD-SS: pain symptom | No | Ref | ||
| Yes | 1.60 | 0.72-3.57 | .25 | |
| ECD-SS: vision symptom | No | Ref | ||
| Yes | 4.35 | 1.99-9.50 | .0002 | |
| ECD-SS: respiratory symptom | No | Ref | ||
| Yes | 2.66 | 1.24-5.72 | .01 | |
| Top 3 ECD-SS symptoms: severity | Continuous | 1.81 | 1.38-2.37 | <.0001 |
| Top 5 ECD-SS symptoms: severity | Continuous | 1.85 | 1.41-2.43 | <.0001 |
Abbreviations are explained in Table 2.
All but 3 patients who reported no neurologic symptoms also reported no depression.