Associations with moderate or severe anxiety at enrollment
| Variable . | Category . | OR . | 95% CI . | P value . |
|---|---|---|---|---|
| Sex | Male | Ref | ||
| Female | 1.42 | 0.64-3.14 | .39 | |
| Age at histiocytosis diagnosis | Continuous, y | 0.98 | 0.95-1.01 | .12 |
| Age at enrollment | Continuous, y | 0.97 | 0.94-1.00 | .04 |
| Diagnosis | Non-ECD | Ref | ||
| ECD or mixed ECD | 0.75 | 0.32-1.77 | .51 | |
| Neurologic involvement | No | Ref | ||
| Yes | 0.77 | 0.34-1.74 | .52 | |
| Driver mutation | None or other | Ref | ||
| BRAFV600E | 0.99 | 0.41-2.43 | .99 | |
| RAS isoform only | 1.80 | 0.43-7.50 | .42 | |
| MAP2K1 only | 1.35 | 0.33-5.47 | .67 | |
| Length of undiagnosed illness | Continuous, y | 0.99 | 0.88-1.12 | .86 |
| Length of diagnosed illness | Continuous, y | 0.97 | 0.91-1.04 | .42 |
| Treatment at enrollment | None | Ref | ||
| Conventional | 2.56 | 0.69-9.57 | .16 | |
| Targeted | 1.28 | 0.53-3.07 | .59 | |
| Best response at enrollment | PR/CR | Ref | ||
| SD/PD | 1.03 | 0.24-4.48 | .96 | |
| Education | High school or some high school | Ref | ||
| Undergraduate | 0.43 | 0.15-1.19 | .10 | |
| Graduate or postgraduate | 0.32 | 0.12-0.84 | .02 | |
| Employment at enrollment | Full-time | Ref | ||
| Part-time | 0.75 | 0.20-2.85 | .67 | |
| Unemployed | 1.41 | 0.54-3.72 | .49 | |
| Retired | 0.49 | 0.15-1.59 | .23 | |
| Financial burden scale | Continuous | 1.21 | 1.01-1.45 | .04 |
| Financial worry scale | Continuous | 1.81 | 1.33-2.47 | .0002 |
| FACT-Cog: perceived cognitive impairments scale | Continuous | 0.98 | 0.96-1.00 | .10 |
| FACT-Cog: perceived cognitive impairments on QoL scale | Continuous | 0.87 | 0.81-0.94 | .0004 |
| FACT-Cog: comments from others scale | Continuous | 0.85 | 0.76-0.96 | .006 |
| FACT-Cog: perceived cognitive abilities scale | Continuous | 0.96 | 0.91-1.01 | .12 |
| FACT-G: physical well-being scale | Continuous | 0.91 | 0.86-0.97 | .002 |
| FACT-G: emotional well-being scale | Continuous | 0.69 | 0.61-0.79 | <.0001 |
| FACT-G: social well-being scale | Continuous | 0.88 | 0.82-0.93 | <.0001 |
| FACT-G: functional well-being scale | Continuous | 0.86 | 0.80-0.92 | <.0001 |
| FACT-G: total | Continuous | 0.93 | 0.91-0.96 | <.0001 |
| BFI: total | Continuous | 1.27 | 1.10-1.46 | .001 |
| BPI: total | Continuous | 1.21 | 1.05-1.40 | .0095 |
| ECD-SS: neurologic symptom | No | Ref | ||
| Yes | Not | Estimable∗ | ||
| ECD-SS: gastrological symptom | No | Ref | ||
| Yes | 2.88 | 1.05-7.91 | .04 | |
| ECD-SS: pain symptom | No | Ref | ||
| Yes | 1.51 | 0.65-3.52 | .34 | |
| ECD-SS: vision symptom | No | Ref | ||
| Yes | 1.33 | 0.58-3.07 | .50 | |
| ECD-SS: respiratory symptom | No | Ref | ||
| Yes | 2.19 | 0.98-4.92 | .06 | |
| Top 3 ECD-SS symptoms: severity | Continuous | 1.34 | 1.07-1.68 | .01 |
| Top 5 ECD-SS symptoms: severity | Continuous | 1.52 | 1.18-1.96 | .001 |
| Variable . | Category . | OR . | 95% CI . | P value . |
|---|---|---|---|---|
| Sex | Male | Ref | ||
| Female | 1.42 | 0.64-3.14 | .39 | |
| Age at histiocytosis diagnosis | Continuous, y | 0.98 | 0.95-1.01 | .12 |
| Age at enrollment | Continuous, y | 0.97 | 0.94-1.00 | .04 |
| Diagnosis | Non-ECD | Ref | ||
| ECD or mixed ECD | 0.75 | 0.32-1.77 | .51 | |
| Neurologic involvement | No | Ref | ||
| Yes | 0.77 | 0.34-1.74 | .52 | |
| Driver mutation | None or other | Ref | ||
| BRAFV600E | 0.99 | 0.41-2.43 | .99 | |
| RAS isoform only | 1.80 | 0.43-7.50 | .42 | |
| MAP2K1 only | 1.35 | 0.33-5.47 | .67 | |
| Length of undiagnosed illness | Continuous, y | 0.99 | 0.88-1.12 | .86 |
| Length of diagnosed illness | Continuous, y | 0.97 | 0.91-1.04 | .42 |
| Treatment at enrollment | None | Ref | ||
| Conventional | 2.56 | 0.69-9.57 | .16 | |
| Targeted | 1.28 | 0.53-3.07 | .59 | |
| Best response at enrollment | PR/CR | Ref | ||
| SD/PD | 1.03 | 0.24-4.48 | .96 | |
| Education | High school or some high school | Ref | ||
| Undergraduate | 0.43 | 0.15-1.19 | .10 | |
| Graduate or postgraduate | 0.32 | 0.12-0.84 | .02 | |
| Employment at enrollment | Full-time | Ref | ||
| Part-time | 0.75 | 0.20-2.85 | .67 | |
| Unemployed | 1.41 | 0.54-3.72 | .49 | |
| Retired | 0.49 | 0.15-1.59 | .23 | |
| Financial burden scale | Continuous | 1.21 | 1.01-1.45 | .04 |
| Financial worry scale | Continuous | 1.81 | 1.33-2.47 | .0002 |
| FACT-Cog: perceived cognitive impairments scale | Continuous | 0.98 | 0.96-1.00 | .10 |
| FACT-Cog: perceived cognitive impairments on QoL scale | Continuous | 0.87 | 0.81-0.94 | .0004 |
| FACT-Cog: comments from others scale | Continuous | 0.85 | 0.76-0.96 | .006 |
| FACT-Cog: perceived cognitive abilities scale | Continuous | 0.96 | 0.91-1.01 | .12 |
| FACT-G: physical well-being scale | Continuous | 0.91 | 0.86-0.97 | .002 |
| FACT-G: emotional well-being scale | Continuous | 0.69 | 0.61-0.79 | <.0001 |
| FACT-G: social well-being scale | Continuous | 0.88 | 0.82-0.93 | <.0001 |
| FACT-G: functional well-being scale | Continuous | 0.86 | 0.80-0.92 | <.0001 |
| FACT-G: total | Continuous | 0.93 | 0.91-0.96 | <.0001 |
| BFI: total | Continuous | 1.27 | 1.10-1.46 | .001 |
| BPI: total | Continuous | 1.21 | 1.05-1.40 | .0095 |
| ECD-SS: neurologic symptom | No | Ref | ||
| Yes | Not | Estimable∗ | ||
| ECD-SS: gastrological symptom | No | Ref | ||
| Yes | 2.88 | 1.05-7.91 | .04 | |
| ECD-SS: pain symptom | No | Ref | ||
| Yes | 1.51 | 0.65-3.52 | .34 | |
| ECD-SS: vision symptom | No | Ref | ||
| Yes | 1.33 | 0.58-3.07 | .50 | |
| ECD-SS: respiratory symptom | No | Ref | ||
| Yes | 2.19 | 0.98-4.92 | .06 | |
| Top 3 ECD-SS symptoms: severity | Continuous | 1.34 | 1.07-1.68 | .01 |
| Top 5 ECD-SS symptoms: severity | Continuous | 1.52 | 1.18-1.96 | .001 |
BFI, brief fatigue inventory; CR, complete response; PD, progressive disease; PR, partial response; Ref, reference; SD, stable disease.
All the patients who reported no neurologic symptoms also reported no anxiety.