Treatment discontinuation/change by treatment lines
| . | Initial treatment (n = 997) . | Treatment 2 (n = 370) . | Treatment 3 (n = 176) . | Treatment 4 (n = 87) . | Treatment 5 (n = 42) . |
|---|---|---|---|---|---|
| Main treatment ongoing | 502 (50.4) | 146 (39.5) | 57 (32.4) | 22 (25.3) | 15 (35.7) |
| Main treatment discontinued or changed | 495 (49.6) | 224 (60.5) | 119 (67.6) | 65 (74.7) | 27 (64.3) |
| Reason for discontinuation or change | |||||
| Inadequate response | 135 (27.3) | 80 (35.7) | 39 (32.8) | 19 (29.2) | 8 (29.6) |
| Disease progression | 88 (17.8) | 21 (9.4) | 9 (7.6) | 8 (12.3) | 5 (18.5) |
| Toxicity | 57 (11.5) | 20 (8.9) | 15 (12.6) | 6 (9.2) | 1 (3.7) |
| Financial/insurance | 4 (0.8) | 0 | 0 | 2 (3.1) | 0 |
| Completed planned treatment | 25 (5.1) | 14 (6.3) | 9 (7.6) | 1 (1.5) | 3 (11.1) |
| Decline in performance status | 4 (0.8) | 5 (2.2) | 3 (2.5) | 2 (3.1) | 1 (3.7) |
| Dead | 30 (6.1) | 11 (4.9) | 12 (10.1) | 6 (9.2) | 4 (14.8) |
| Patient preference | 7 (1.4) | 7 (3.1) | 0 | 0 | 0 |
| Physician preference | 60 (12.1) | 30 (13.4) | 15 (12.6) | 3 (4.6) | 1 (3.7) |
| Other | 67 (13.5) | 26 (11.6) | 13 (10.9) | 15 (23.1) | 3 (11.1) |
| Not documented | 18 (3.6) | 10 (4.5) | 4 (3.4) | 3 (4.6) | 1 (3.7) |
| . | Initial treatment (n = 997) . | Treatment 2 (n = 370) . | Treatment 3 (n = 176) . | Treatment 4 (n = 87) . | Treatment 5 (n = 42) . |
|---|---|---|---|---|---|
| Main treatment ongoing | 502 (50.4) | 146 (39.5) | 57 (32.4) | 22 (25.3) | 15 (35.7) |
| Main treatment discontinued or changed | 495 (49.6) | 224 (60.5) | 119 (67.6) | 65 (74.7) | 27 (64.3) |
| Reason for discontinuation or change | |||||
| Inadequate response | 135 (27.3) | 80 (35.7) | 39 (32.8) | 19 (29.2) | 8 (29.6) |
| Disease progression | 88 (17.8) | 21 (9.4) | 9 (7.6) | 8 (12.3) | 5 (18.5) |
| Toxicity | 57 (11.5) | 20 (8.9) | 15 (12.6) | 6 (9.2) | 1 (3.7) |
| Financial/insurance | 4 (0.8) | 0 | 0 | 2 (3.1) | 0 |
| Completed planned treatment | 25 (5.1) | 14 (6.3) | 9 (7.6) | 1 (1.5) | 3 (11.1) |
| Decline in performance status | 4 (0.8) | 5 (2.2) | 3 (2.5) | 2 (3.1) | 1 (3.7) |
| Dead | 30 (6.1) | 11 (4.9) | 12 (10.1) | 6 (9.2) | 4 (14.8) |
| Patient preference | 7 (1.4) | 7 (3.1) | 0 | 0 | 0 |
| Physician preference | 60 (12.1) | 30 (13.4) | 15 (12.6) | 3 (4.6) | 1 (3.7) |
| Other | 67 (13.5) | 26 (11.6) | 13 (10.9) | 15 (23.1) | 3 (11.1) |
| Not documented | 18 (3.6) | 10 (4.5) | 4 (3.4) | 3 (4.6) | 1 (3.7) |
The full analysis set includes all patients who received at least 1 dose of the first treatment. Calculated based on the number of patients in the full analysis set. For a patient with multiple treatment lines, the reason for each drug discontinuation or change was counted. One treatment line per patient has only 1 discontinuation reason. All treatment lines for a patient will be displayed from 1L to 5L, if applicable.