HRs of incident VTE in relation to 1 interquartile range greater estimated concentration of chronic air pollutants though the first 10 years of follow-up: the MESA 2000 to 2012
| Variable . | PM2.5 (per 3.6 μg/m3) . | NO2 (per 13.3 ppb) . | NOx (per 30.0 ppb) . | O3 (per 5.8 ppb) . |
|---|---|---|---|---|
| No. at risk | 6651 | 6651 | 6651 | 6651 |
| VTE, no. | 152 | 152 | 152 | 152 |
| Model 1 HR (95% CI) | 2.03 (1.41-2.92) | 3.59 (1.77-7.29) | 2.37 (1.40-3.99) | 0.77 (0.47-1.27) |
| Model 2 HR (95% CI) | 1.94 (1.35-2.79) | 3.38 (1.66-6.86) | 2.25 (1.32-3.84) | 0.78 (0.48-1.29) |
| Model 3 HR (95% CI)∗ | 1.92 (1.32-2.78) | 3.67 (1.83-7.38) | 2.23 (1.29-3.85) | 0.76 (0.46-1.26) |
| Noncancer VTE, no. | 100 | 100 | 100 | 100 |
| Model 1 HR (95% CI) | 2.74 (1.84-4.07) | 5.04 (2.30-11.04) | 2.56 (1.34-4.89) | 0.80 (0.43-1.49) |
| Model 2 HR (95% CI) | 2.61 (1.76-3.85) | 4.66 (2.12-10.27) | 2.40 (1.24-4.64) | 0.83 (0.45-1.54) |
| Model 3 HR (95% CI)∗ | 2.47 (1.66-3.67) | 4.25 (1.92-9.41) | 2.14 (1.09-4.19) | 0.83 (0.45-1.54) |
| Variable . | PM2.5 (per 3.6 μg/m3) . | NO2 (per 13.3 ppb) . | NOx (per 30.0 ppb) . | O3 (per 5.8 ppb) . |
|---|---|---|---|---|
| No. at risk | 6651 | 6651 | 6651 | 6651 |
| VTE, no. | 152 | 152 | 152 | 152 |
| Model 1 HR (95% CI) | 2.03 (1.41-2.92) | 3.59 (1.77-7.29) | 2.37 (1.40-3.99) | 0.77 (0.47-1.27) |
| Model 2 HR (95% CI) | 1.94 (1.35-2.79) | 3.38 (1.66-6.86) | 2.25 (1.32-3.84) | 0.78 (0.48-1.29) |
| Model 3 HR (95% CI)∗ | 1.92 (1.32-2.78) | 3.67 (1.83-7.38) | 2.23 (1.29-3.85) | 0.76 (0.46-1.26) |
| Noncancer VTE, no. | 100 | 100 | 100 | 100 |
| Model 1 HR (95% CI) | 2.74 (1.84-4.07) | 5.04 (2.30-11.04) | 2.56 (1.34-4.89) | 0.80 (0.43-1.49) |
| Model 2 HR (95% CI) | 2.61 (1.76-3.85) | 4.66 (2.12-10.27) | 2.40 (1.24-4.64) | 0.83 (0.45-1.54) |
| Model 3 HR (95% CI)∗ | 2.47 (1.66-3.67) | 4.25 (1.92-9.41) | 2.14 (1.09-4.19) | 0.83 (0.45-1.54) |
Model 1: Cox regression adjusted for age, sex, race/ethnicity, site, and education.
Model 2: Model 1 + adjustment for smoking status, secondhand smoke exposure, physical activity, and body mass index.
Model 3: Model 2 + adjustment for D-dimer, factor VIII, interleukin-6, C-reactive protein, and fibrinogen.
Slight reduction in sample size.