Table 4. Univariate and multivariate OS... | American Society of Hematology

Table 4.

Univariate and multivariate OS analysis for the total HPRSS score at baseline

Variable	Univariate		Multivariate
Variable	HR (95% CI)	P value	HR (95% CI)	P value
Total score group∗
2 vs 1	1.5 (1.1-2.0)	.003	1.5 (1.0-2.1)	.03
3 vs 1	2.2 (1.7-3.0)	<.001	1.6 (1.1-2.3)	.02
3 vs 2	1.5 (1.2-1.9)	.002	1.1 (0.8-1.5)	.71
Age			1.05 (1.03-1.07)	<.001
High-risk FISH†			2.0 (1.5-2.7)	<.001
ISS III			1.4 (1.1-2.0)	.02
ASCT after induction			0.6 (0.4-0.8)	.003

Variable	Univariate		Multivariate
Variable	HR (95% CI)	P value	HR (95% CI)	P value
Total score group∗
2 vs 1	1.5 (1.1-2.0)	.003	1.5 (1.0-2.1)	.03
3 vs 1	2.2 (1.7-3.0)	<.001	1.6 (1.1-2.3)	.02
3 vs 2	1.5 (1.2-1.9)	.002	1.1 (0.8-1.5)	.71
Age			1.05 (1.03-1.07)	<.001
High-risk FISH†			2.0 (1.5-2.7)	<.001
ISS III			1.4 (1.1-2.0)	.02
ASCT after induction			0.6 (0.4-0.8)	.003

Statistically significant P values are indicated in bold.

Groups are defined using tertiles of the total HPRSS score: group 1 (score of <8), group 2 (score of 8-14), and group 3 (score of >14)

Defined as presence of t(4;14), t(14;16), t(16;20), del 17p, and/or 1q gain/amplification.