Univariate and multivariate OS analysis for fatigue, pain, and QOL at diagnosis
| Variable . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Age | 1.05 (1.04-1.06) | <.001 | 1.04 (1.03-1.06) | <.001 |
| ISS III | 2.3 (1.8-2.8) | <.001 | 1.4 (1.0-1.9) | .04 |
| High-risk FISH∗ | 2.0 (1.6-2.4) | <.001 | 2.0 (1.5-2.7) | <.001 |
| ASCT after induction | 0.5 (0.4-0.5) | <.001 | 0.6 (0.4-0.8) | .001 |
| Fatigue, ≥5 | 1.8 (1.4-2.2) | <.001 | 1.7 (1.3-2.4) | <.001 |
| Pain, ≥5 | 1.5 (1.2-1.9) | <.001 | 0.9 (0.7-1.3) | .74 |
| QOL, ≤5 | 1.7 (1.3-2.1) | <.001 | 1.4 (1.0-1.9) | .03 |
| Variable . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Age | 1.05 (1.04-1.06) | <.001 | 1.04 (1.03-1.06) | <.001 |
| ISS III | 2.3 (1.8-2.8) | <.001 | 1.4 (1.0-1.9) | .04 |
| High-risk FISH∗ | 2.0 (1.6-2.4) | <.001 | 2.0 (1.5-2.7) | <.001 |
| ASCT after induction | 0.5 (0.4-0.5) | <.001 | 0.6 (0.4-0.8) | .001 |
| Fatigue, ≥5 | 1.8 (1.4-2.2) | <.001 | 1.7 (1.3-2.4) | <.001 |
| Pain, ≥5 | 1.5 (1.2-1.9) | <.001 | 0.9 (0.7-1.3) | .74 |
| QOL, ≤5 | 1.7 (1.3-2.1) | <.001 | 1.4 (1.0-1.9) | .03 |
Defined as presence of t(4;14), t(14;16), t(16;20), del 17p, and/or 1q gain/amplification.