Characteristics of primary patient samples used in gene activity studies
| ID . | Alterations . | Final subtype . | RNA-seq sample type . | BCL2_SIG . | BCL2L1_SIG . | MCL1_SIG . | Navitoclax_AUC . | AZD4320_AUC . | AZD5991_AUC . | AZD3202_AUC . |
|---|---|---|---|---|---|---|---|---|---|---|
| SJALL068378_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.161123343 | 0.297878018 | 0.283187653 | 6.92 | 4.796 | 8.385 | 4.976 |
| SJALL068371_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.164212402 | 0.280235192 | 0.362725949 | 7.515 | 5.932 | 7.751 | 9.09 |
| SJALL068426_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.169629934 | 0.301991468 | 0.251066081 | 7.154 | 6.963 | 9.756 | 6.458 |
| SJALL068412_X1 | TLX3 overexpression | TLX3 | PDX | 0.177082138 | 0.281105117 | 0.326443938 | 10.86 | 8.089 | 10.435 | 7.343 |
| SJALL068439_X1 | LYL1::TRB | LYL1 | PDX | 0.187850451 | 0.31320111 | 0.339500387 | 9.259 | 6.645 | 9.815 | 8.367 |
| SJALL068383_X1 | TAL1 overexpression | TAL1 | PDX | 0.146731322 | 0.308581267 | 0.295253413 | 4.733 | 7.121 | 7.016 | 6.543 |
| SJALL068399_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.181634202 | 0.308624573 | 0.24844915 | 4.402 | 6.807 | 8.945 | 6.404 |
| SJALL068395_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.157522101 | 0.300441164 | 0.410820809 | 12.395 | 8.268 | 10.951 | 10.951 |
| SJALL068400_X1 | LYL1::TRB (but LYL1 expression is low) | LYL1 | PDX | 0.217354708 | 0.258394302 | 0.754426451 | 10.094 | 7.568 | ||
| SJALL068408_X1 | TLX3 overexpression | TLX3 | PDX | 0.216314445 | 0.281007657 | 0.361744227 | 7.705 | 7.16 | 9.137 | 8.241 |
| SJTALL055667_R2 | TLX3::14q32.2; TLX3 overexpression | TLX3 | Primary | 0.370879302 | 0.197211276 | 0.478839168 | 3.911 | 3.982 | 6.864 | 4.933 |
| SJTALL055667_R1 | TLX3::14q32.2; TLX3 overexpression | TLX3 | Primary | 0.367791552 | 0.194304436 | 0.559975966 | 2.126 | 3.67 | 6.883 | 7.173 |
| ID . | Alterations . | Final subtype . | RNA-seq sample type . | BCL2_SIG . | BCL2L1_SIG . | MCL1_SIG . | Navitoclax_AUC . | AZD4320_AUC . | AZD5991_AUC . | AZD3202_AUC . |
|---|---|---|---|---|---|---|---|---|---|---|
| SJALL068378_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.161123343 | 0.297878018 | 0.283187653 | 6.92 | 4.796 | 8.385 | 4.976 |
| SJALL068371_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.164212402 | 0.280235192 | 0.362725949 | 7.515 | 5.932 | 7.751 | 9.09 |
| SJALL068426_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.169629934 | 0.301991468 | 0.251066081 | 7.154 | 6.963 | 9.756 | 6.458 |
| SJALL068412_X1 | TLX3 overexpression | TLX3 | PDX | 0.177082138 | 0.281105117 | 0.326443938 | 10.86 | 8.089 | 10.435 | 7.343 |
| SJALL068439_X1 | LYL1::TRB | LYL1 | PDX | 0.187850451 | 0.31320111 | 0.339500387 | 9.259 | 6.645 | 9.815 | 8.367 |
| SJALL068383_X1 | TAL1 overexpression | TAL1 | PDX | 0.146731322 | 0.308581267 | 0.295253413 | 4.733 | 7.121 | 7.016 | 6.543 |
| SJALL068399_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.181634202 | 0.308624573 | 0.24844915 | 4.402 | 6.807 | 8.945 | 6.404 |
| SJALL068395_X1 | STIL::TAL1; TAL1 overexpression | TAL1 | PDX | 0.157522101 | 0.300441164 | 0.410820809 | 12.395 | 8.268 | 10.951 | 10.951 |
| SJALL068400_X1 | LYL1::TRB (but LYL1 expression is low) | LYL1 | PDX | 0.217354708 | 0.258394302 | 0.754426451 | 10.094 | 7.568 | ||
| SJALL068408_X1 | TLX3 overexpression | TLX3 | PDX | 0.216314445 | 0.281007657 | 0.361744227 | 7.705 | 7.16 | 9.137 | 8.241 |
| SJTALL055667_R2 | TLX3::14q32.2; TLX3 overexpression | TLX3 | Primary | 0.370879302 | 0.197211276 | 0.478839168 | 3.911 | 3.982 | 6.864 | 4.933 |
| SJTALL055667_R1 | TLX3::14q32.2; TLX3 overexpression | TLX3 | Primary | 0.367791552 | 0.194304436 | 0.559975966 | 2.126 | 3.67 | 6.883 | 7.173 |