Multivariable analysis across all 4 groups
| Variable . | Group I . | Group II . | Group III . | Group IV . |
|---|---|---|---|---|
| CNI-MTX (n = 210) . | ATG-CNI-MTX (n = 34) . | PTCy-ATG-CNI (n = 78) . | PTCy-CNI- MMF (n = 91) . | |
| OS | Ref | 0.9 (0.5-1.5); P = .75 | 0.6 (0.3-0.8); P = .01 | 0.5 (0.3-0.9); P = .01 |
| GRFS | Ref | 0.6 (0.4 -1.1); P = .14 | 0.4 (0.3-0.6); P < .01 | 0.4 (0.2-0.6); P < .01 |
| NRM | Ref | 0.6 (0.3-1.4); P = .3 | 0.4 (0.2-0.8); P = .01 | 0.3 (0.1-0.6); P < .01 |
| aGVHD grade 2-4 | Ref | 0.6 (0.4-1.2); P = .1 | 0.4 (0.2-0.7); P < .01 | 0.6 (0.4-0.9); P = .01 |
| aGVHD grade 3-4 | Ref | 0.3 (0.1 -1.2); P = .1 | 0.3 (0.1- 0.8); P = .01 | 0.2 (0.1 - 0.6); P < .01 |
| cGVHD | Ref | 0.2 (0.1-0.5); P < .01 | 0.3 (0.2-0.4); P < .01 | 0.5 (0.4-0.7); P < .01 |
| cGVHD moderate to severe | Ref | 0.1 (0.1-0.5); P < .01 | 0.2 (0.1-0.3); P < .01 | 0.4 (0.2-0.6); P < .01 |
| BSIs | Ref | 0.9 (0.5-1.7); P = .9 | 1.6 (1.2-2.5); P < .01 | 1.5 (1.3-2.3); P < .01 |
| Variable . | Group I . | Group II . | Group III . | Group IV . |
|---|---|---|---|---|
| CNI-MTX (n = 210) . | ATG-CNI-MTX (n = 34) . | PTCy-ATG-CNI (n = 78) . | PTCy-CNI- MMF (n = 91) . | |
| OS | Ref | 0.9 (0.5-1.5); P = .75 | 0.6 (0.3-0.8); P = .01 | 0.5 (0.3-0.9); P = .01 |
| GRFS | Ref | 0.6 (0.4 -1.1); P = .14 | 0.4 (0.3-0.6); P < .01 | 0.4 (0.2-0.6); P < .01 |
| NRM | Ref | 0.6 (0.3-1.4); P = .3 | 0.4 (0.2-0.8); P = .01 | 0.3 (0.1-0.6); P < .01 |
| aGVHD grade 2-4 | Ref | 0.6 (0.4-1.2); P = .1 | 0.4 (0.2-0.7); P < .01 | 0.6 (0.4-0.9); P = .01 |
| aGVHD grade 3-4 | Ref | 0.3 (0.1 -1.2); P = .1 | 0.3 (0.1- 0.8); P = .01 | 0.2 (0.1 - 0.6); P < .01 |
| cGVHD | Ref | 0.2 (0.1-0.5); P < .01 | 0.3 (0.2-0.4); P < .01 | 0.5 (0.4-0.7); P < .01 |
| cGVHD moderate to severe | Ref | 0.1 (0.1-0.5); P < .01 | 0.2 (0.1-0.3); P < .01 | 0.4 (0.2-0.6); P < .01 |
| BSIs | Ref | 0.9 (0.5-1.7); P = .9 | 1.6 (1.2-2.5); P < .01 | 1.5 (1.3-2.3); P < .01 |