Outcome probabilities (with 95% CI) at 3 years, stratified by conditioning intensity and pre- and/or post-HCT MRD status or MRD dynamics
| . | Cumulative incidence of relapse at 3 y . | RFS at 3 y . | OS at 3 y . | Cumulative incidence of NRM at 3 y . |
|---|---|---|---|---|
| All patients (N = 935) | 19% (16%-21%) | 68% (65%-71%) | 73% (70%-76%) | 13% (11%-15%) |
| Pre-HCT MRD information only | ||||
| MRDneg (n = 799) | 15% (12%-18%) | 72% (69%-75%) | 76% (73%-79%) | 13% (11%-16%) |
| MRDpos (n = 136) | 41% (33%-50%) | 47% (39%-56%) | 53% (45%-63%) | 12% (7%-18%) |
| Day +70 to +100 post-HCT MRD information only | ||||
| MRDneg (n = 924) | 18% (15%-21%) | 69% (66%-72%) | 73% (70%-76%) | 13% (11%-15%) |
| MRDpos (n = 11) | 55% (18%-81%) | 9% (1%-59%) | 18% (5%-64%) | 36% (10%-65%) |
| Pre-HCT/day +70 to +100 MRD information | ||||
| MRDneg/MRDneg (n = 798) | 15% (13%-18%) | 72% (69%-75%) | 76% (73%-79%) | 13% (11%-16%) |
| MRDneg/MRDpos (n = 1) | - | 0% | 0% | 100% |
| MRDpos/MRDneg (n = 126) | 40% (31%-49%) | 50% (41%-59%) | 56% (48%-66%) | 11% (6%-17%) |
| MRDpos/MRDpos (n = 10) | 60% (20%-85%) | 10% (2%-64%) | 13% (6%-69%) | 30% (6%-60%) |
| Day +20 o +40/day +70 to +100 MRD information | ||||
| MRDneg/MRDneg (n = 897) | 18% (16%-21%) | 70% (67%-73%) | 74% (72%-77%) | 12% (10%-14%) |
| MRDneg/MRDpos (n = 5) | 60% (15%-95%) | 0% | 0% | 40% (5%-85%) |
| MRDpos/MRDneg (n = 9) | 22% (3%-53%) | 40% (17%-94%) | 35% (12%-98%) | 38% (7%-701%) |
| MRDpos/MRDpos (n = 6) | 67% (10%-93%) | 17% (3%-100%) | 19% (11%-100%) | 17% (1%-56%) |
| . | Cumulative incidence of relapse at 3 y . | RFS at 3 y . | OS at 3 y . | Cumulative incidence of NRM at 3 y . |
|---|---|---|---|---|
| All patients (N = 935) | 19% (16%-21%) | 68% (65%-71%) | 73% (70%-76%) | 13% (11%-15%) |
| Pre-HCT MRD information only | ||||
| MRDneg (n = 799) | 15% (12%-18%) | 72% (69%-75%) | 76% (73%-79%) | 13% (11%-16%) |
| MRDpos (n = 136) | 41% (33%-50%) | 47% (39%-56%) | 53% (45%-63%) | 12% (7%-18%) |
| Day +70 to +100 post-HCT MRD information only | ||||
| MRDneg (n = 924) | 18% (15%-21%) | 69% (66%-72%) | 73% (70%-76%) | 13% (11%-15%) |
| MRDpos (n = 11) | 55% (18%-81%) | 9% (1%-59%) | 18% (5%-64%) | 36% (10%-65%) |
| Pre-HCT/day +70 to +100 MRD information | ||||
| MRDneg/MRDneg (n = 798) | 15% (13%-18%) | 72% (69%-75%) | 76% (73%-79%) | 13% (11%-16%) |
| MRDneg/MRDpos (n = 1) | - | 0% | 0% | 100% |
| MRDpos/MRDneg (n = 126) | 40% (31%-49%) | 50% (41%-59%) | 56% (48%-66%) | 11% (6%-17%) |
| MRDpos/MRDpos (n = 10) | 60% (20%-85%) | 10% (2%-64%) | 13% (6%-69%) | 30% (6%-60%) |
| Day +20 o +40/day +70 to +100 MRD information | ||||
| MRDneg/MRDneg (n = 897) | 18% (16%-21%) | 70% (67%-73%) | 74% (72%-77%) | 12% (10%-14%) |
| MRDneg/MRDpos (n = 5) | 60% (15%-95%) | 0% | 0% | 40% (5%-85%) |
| MRDpos/MRDneg (n = 9) | 22% (3%-53%) | 40% (17%-94%) | 35% (12%-98%) | 38% (7%-701%) |
| MRDpos/MRDpos (n = 6) | 67% (10%-93%) | 17% (3%-100%) | 19% (11%-100%) | 17% (1%-56%) |